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Increased endothelin receptor B and G protein coupled kinase-2 in the mesentery of portal hypertensive rats

World Journal of Gastroenterology 2013年第13期19卷 2065-2072页

作者： Qing-Hong Du Lin Han Jun-Jie Jiang Peng-Tao Li Xin-Yue Wang Xu Jia Department of Pathology School of Fundamental MedicineBeijing University of Chinese Medicine

AIM: To elucidate the mechanisms of mesenteric vasodilation in portal hypertension (PHT), with a focus on endothelin signaling. METHODS: PHT was induced in rats by common bile duct ligation (CBDL). Portal pressure (PP) was measured directly via catheters placed in the portal vein tract. The level of endothelin-1 (ET-1) in the mesenteric circulation was determined by radioimmunoassay, and the expression of the endothelin A receptor (ETAR) and endothelin B receptor (ETBR) was assessed by immunofluorescence and Western blot. Additionally, expression of G protein coupled kinase-2 (GRK2) and β-arrestin 2, which influence endothelin receptor sensitivity, were also studied by Western blot. RESULTS: PP of CBDL rats increased significantly (11.89 ± 1.38 mmHg vs 16.34 ± 1.63 mmHg). ET-1 expression decreased in the mesenteric circulation 2 and 4 wk after CBDL. ET-1 levels in the systemic circulation of CBDL rats were increased at 2 wk and decreased at 4 wk. There was no change in ETAR expression in response to CBDL; however, increased expression of ETBR in the endothelial cells of mesenteric arterioles and capillaries was observed. In sham-operated rats, ETBR was mainly expressed in the CD31+ endothelial cells of the arterioles. With development of PHT, in addition to the endothelial cells, ETBR expression was noticeably detectable in the SMA+ smooth muscle cells of arterioles and in the CD31+ capillaries. Following CBDL, increased expression of GRK2 was also found in mesenteric tissue, though there was no change in the level of β-arrestin 2. CONCLUSION: Decreased levels of ET-1 and increased ETBR expression in the mesenteric circulation following CBDL in rats may underlie mesenteric vasodilation in individuals with PHT. Mechanistically, increased GRK2 expression may lead to desensitization of ETAR, as well as other vasoconstrictors, promoting this vasodilatory effect.

关键词： Portal hypertension mesentery Endothelin Endothelin B receptor G protein coupled kinase-2

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Extensive abdominal lymphangiomatosis involving the small bowel mesentery: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9990-9996页

作者： Ayman S Alhasan Tareef S Daqqaq Department of Radiology and Medical Imaging College of Medicine Taibah UniversityMadinah 42353Saudi Arabia

BACKGROUND Abdominal lymphangiomatosis is a rare benign condition accounting for less than 1%of all the cases of *** usually involves radical surgical excision;however,depending upon the extent of involvement,patient condition,and absence of complications,conservative management can be also *** SUMMARY We present the case of a 32-year-old male who presented with short onset abdominal pain and *** examination findings were within normal limits,except for left lower abdominal *** gastrointestinal endoscopy was within normal *** and pelvic ultrasound and computed tomography(CT)scan revealed numerous,variably-sized cystic lesions within the abdominal cavity,exclusively and extensively affecting the small bowel mesentery with sparing of the *** diagnosis was confirmed by CT and cytological *** surgical excision was technically impossible in this patient because of the extensive involvement of the mesentery;therefore,the patient was managed *** Extensive and exclusive small bowel mesentery involvement in abdominal lymphangiomatosis is *** modalities play an important role in establishing the diagnosis and conservative management can be considered when surgery is technically impossible.

关键词： Abdominal lymphangiomatosis mesentery Melena Computed tomography scan Case report

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Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats

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World Journal of Gastroenterology 2014年第44期20卷 16674-16682页

作者： Qing-Hong Du Lin Han Jun-Jie Jiang Ya Xu Wei-Hong Li Peng-Tao Li Xin-Yue Wang Xu Jia School of Fundamental Medicine Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

AIM: To investigate the effects of Glytan on splanchnic hemodynamics and its reduction of portal pressure in portal hypertensive rats.

关键词： Glytan Portal hypertension Hemodynamics mesentery Endothelin-1 Receptor Sensitivity

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Metastatic low-grade endometrial stromal sarcoma with variable morphologies in the ovaries and mesentery: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8384-8391页

作者： Hai-Yun Yu Yu-Lan Jin Department of Pathology Beijing Obstetrics and Gynecology HospitalCapital Medical University.Beijing Maternal and Child Health Care HospitalBeijing 100003China

BACKGROUND Low-grade endometrial stromal sarcoma(LGESS)classically exhibits a proliferative ***,morphological variation of extrauterine tumors presents a diagnostic *** SUMMARY We report the case of a 76-year-old female patient with extensive extrauterine and abdominal neoplastic *** tomography showed massive pleural and ascitic fluid,and there was an increase in serum cancer antigen *** underwent bilateral adnexectomy and tumor *** right ovary had been replaced by a multinodular mass that was 8.5 cm×4.5 cm×3.5 cm in *** addition,there was a 24 cm×15 cm×13 cm mesenteric mass,which was also multinodular,with local invasion of the intestinal serosa and underlying *** the microscope,the tumors in different places exhibited two different patterns,thus presenting great challenges to diagnosis and *** pathological assessment eliminated all differential diagnoses in favor of metastatic LGESS derived from a 20-year-old primary tumor initially misdiagnosed as *** LGESS morphology varies according to tumor *** diagnosis is critical for appropriate treatment and improved prognosis and patient care.

关键词： Gastrointestinal stromal tumor Low-grade endometrial stromal sarcoma mesentery Ovary Tumor Case report

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TFE3-expressing malignant perivascular epithelioid cell tumor of the mesentery:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4207-4214页

作者： Nah Ihm Kim Ji Shin Lee Yoo Duk Choi U Chul Ju Jong Hee Nam Department of Pathology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun Hospital and Medical SchoolHwasun 58128South Korea Department of Obstetrics and Gynecology Chonnam National University Hwasun Hospital and Medical SchoolHwasun 58128South Korea

BACKGROUND Perivascular epithelioid cell tumor(PEComa)is a rare mesenchymal tumor that exhibits an epithelioid and spindle cell *** tumor is characterized by immunoreactivity for melanocytic and myogenic markers but can be misdiagnosed as more common tumors with similar characteristics,including gastrointestinal stroma tumors or ***,a subset of PEComas has been reported to harbor a transcription factor binding to TFE3 ***,we report a rare case of TFE3-expressing malignant PEComa arising from the *** SUMMARY A 50-year-old woman presented with abdominal discomfort for 3 *** of laboratory tests were all within the normal ranges,and the patient had no notable medical *** resonance imaging revealed a large tumor on the right side of the pelvic floor,which was originally suspected to be a primary ovarian ***,during surgery,the tumor was revealed to have originated from the ***,the tumor was composed of bundles of spindle cells and sheets of epithelioid *** coagulative necrosis and numerous mitotic figures were *** revealed that the tumor cells were positive for smooth muscle actin,HMB-45,and TFE3 *** involvement of the rectal serosa was identified,leading to a final diagnosis of malignant PEComa of the *** resection was followed by adjuvant *** recurrence or metastasis was observed over a 6-month follow-up *** Malignant PEComa of the mesentery is extremely rare and should be distinguished from morphological mimics through differential diagnosis and immunohistochemistry.

关键词： Perivascular epithelioid cell tumor TFE3 Differential diagnosis mesentery Histology Case report

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Huge peripheral primitive neuroectodermal tumor of the small bowel mesentery at nonage:A case report and review of the literature

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World Journal of Clinical Cases 2016年第9期4卷 306-309页

作者： Zhe Liu Yuan-Hong Xu Chun-Lin Ge Jin Long Rui-Xia Du Ke-Jian Guo Department of Pancreatic Surgery the First Hospital of China Medical University Department of Otorhinolaryngology Fengtian HospitalShenyang Medical University

Extraskeletal Ewing's sarcoma/peripheral primitive neuroectodermal tumor(E-EWS/pP NET) is a rare aggressive malignant small round cell tumor. In this report, we present the case of a 15-year-old boy who suffered from acute abdominal pain accompanied by hematemesis and melena, and was eventually diagnosed with E-EWS/p PNET. To date, there have been only five reported cases of E-EWS/pP NET of the small bowel including the patient in this report. To the best of our knowledge, this is the first documentation of a pP NET of the small bowel mesentery at nonage. All these have made this report rare and significant.

关键词： Extraskeletal Ewing’s sarcoma Peripheral primitive neuroectodermal tumor Nonage Small bowel mesentery Spontaneous rupture

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Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass

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World Journal of Gastrointestinal Oncology 2011年第7期3卷 116-118页

作者： Eun-Jung Cha Department of Pathology Konyang University HospitalKonyang University School of Medicine

Dedifferentiated liposarcoma(DDLPS) is a variant of liposarcoma but with a more aggressive *** occurs most commonly in the retroperitoneum and rarely in any other anatomical *** describe a case of DDLPS arising from the small bowel mesentery presenting as submucosal mass of the small *** current case is unusual as the tumor originated from the small bowel mesentery and a dedifferentiated component transmurally invaded the small bowel wall,including the small bowel submucosa.

关键词： Dedifferentiated liposarcoma Small bowel mesentery

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Lymphangioma of the small bowel mesentery: A case report and review of the literature

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World Journal of Gastroenterology 2012年第43期18卷 6328-6332页

作者： Worapop Suthiwartnarueput Siriphut Kiatipunsodsai Amolchaya Kwankua Utairat Chaumrattanakul Department of Pathology and Forensic Medicine Faculty of Medicine Thammasat University Pathumthani 12120 Thailand Department of Surgery Faculty of Medicine Thammasat University Pathumthani 12120 Thailand Department of Radiology Faculty of Medicine Thammasat University Pathumthani 12120 Thailand

Lymphangioma is a rare benign condition characterized by proliferation of lymphatic spaces. It is usually found in the head and neck of affected children. Lymphangioma of the small-bowel mesentery is rare, having been reported for less than 1% of all lymphangiomas. Importantly, it can cause fatal complications such as volvulus or involvement of the main branch of the mesenteric arteries, requiring emergency surgery. Moreover, the gross and histopathologic findings may resemble benign multicystic mesothelioma and lymphangiomyoma. Immunohistochemical study for factor Ⅷ-related antigen, D2-40, calretinin and human melanoma black-45 (HMB-45) are essential for diagnosis. Factor Ⅷ-related antigen and D2-40 are positive in lymphangioma but negative in benign multicystic mesothelioma. HMB-45 shows positive study in the smooth-muscle cells around the lymphatic spaces of the lymphangiomyoma. We report a case of smallbowel volvulus induced by mesenteric lymphangioma in a 2-year-and-9-mo-old boy who presented with rapid abdominal distension and vomiting. The abdominal computed tomography scan showed a multiseptated mass at the right lower quadrant with a whirllike small-bowel dilatation, suggestive of a mesenteric cyst with midgut volvulus. The intraoperative findings revealed a huge, lobulated, yellowish pink, cystic mass measuring 20 cm × 20 cm × 10 cm, that was originated from the small bowel mesentery with small-bowel volvulus and small-bowel dilatation. Cut surface of the mass revealed multicystic spaces containing a milky white fluid. The patient underwent tumor removal with small-bowel resection and end-to-end anastomosis. Microscopic examination revealed that the cystic walls were lined with flat endothelial cells and comprised of smooth muscle in the walls. The flat endothelial cells were positive for factor Ⅷ-related antigen and D2-40 but negative for calretinin. HMB-45 showed negative study in the smooth-muscle cells around the lymphatic spaces. Thus, the diagnosis w

关键词： Lymphangioma mesentery Small bowel Volvulus Factor Ⅷ-related antigen D2-40

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Tuberculosis versus non-Hodgkin's lymphomas involving small bowel mesentery:Evaluation with contrast-enhanced computed tomography

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World Journal of Gastroenterology 2008年第24期14卷 3914-3918页

作者： Peng Dong Bin Wang Quan-Ye Sun Hui Cui Departmentof Medical Imaging Medical Imaging Centre of the AffiliatedHospital Weifang Medical University Weifang 261042Shandong Province China

AIM: To evaluate the specific computed tomography (CT) imaging criteria for differentiating tuberculosis involving the small bowel mesenteric lymph nodes from lymphomas. METHODS: We retrospectively reviewed the anatomic distribution,CT enhancement patterns of lymphoma in 18 patients with mesenteric tuberculosis and 22 with untreated non-Hodgkin’s lymphomas (NHL) involving small bowel mesentery (SBM). Of the 18 patients with tuberculosis,9 had purely mesenteric tuberculous lymphadenopathy (TL),and 9 had mesenteric TL accompanied with tuberculous mesenteritis (TLM). RESULTS: CT showed that tuberculosis and NHL mainly affected lymph nodes in the body and root of SBM. Homogeneously enhanced lymph nodes in the body and root of SBM were found more often in the NHL (P < 0.05). Homogeneously mixed peripheral enhanced lymph nodes in the body of SBM were found more often in mesenteric TL and TLM (P < 0.05). Peripheral enhanced lymph nodes in the root of SBM were found more often in mesenteric TL and TLM (P < 0.01). "Sandwich sign" in the root of SBM was observed more often in NHL (P < 0.05). CONCLUSION: Anatomic lymph node distribution,sandwich sign and specific enhancement patterns of lymphadenopathy in SBM on CT images can be used in differentiating between tuberculosis and untreated NHL involving SBM.

关键词： Tuberculosis Lymphoma mesentery X-ray Computed tomography

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Optical dynamic imaging of the regional blood flow in the rat mesentery under the effect of noradrenalin

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Progress in Natural Science:Materials International 2003年第5期 79-82页

作者： CHENG Haiying, LUO Qingming, ZENG Shaoqun, CEN Jian and LIANG Wenxi(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China) The Key Laboratory of Biomedical Photonics of Ministry of Education of China Huazhong University of Science and Technology Wuhan 430074 China

The regional blood flow in the rat mesentery under the effect of noradrenalin is monitored using the laser speckle imaging method. The results show that at the third minute of application of noradrenalin, the blood flow begins to decrease, and the venule blood flow decreases more rapidly than that in the arteriole. Five minutes later blood flow in part of blood vessels begins to resume and the blood flow in the arteriole recovers more quickly than that in the venule. These suggest that laser speckle imaging can obtain the temporal-spatial characteristic of blood flow in mesentery without the need of scanning. It provides a new approach for investigating the change of regional blood flow in the mesentery in microcirculation studies.

关键词： laser speckle imaging mesentery regional blood flow.

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