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Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis:A meta-analysis and trial sequential analysis

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World Journal of Clinical Cases 2024年第21期12卷 4703-4716页

作者： Xin-Yu Yang Yun-Feng Yu Ke-Ke Tong Gang Hu Rong Yu Lian-Jun Su School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The benefits and risks of Xileisan(XLS)in the treatment of ulcerative colitis(UC)remain *** The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating *** We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC,up to January ***-analysis and trial sequential analysis(TSA)were performed using Revman 5.3 and TSA 0.***.5.10 beta,*** The present study included 13 clinical studies involving 990 patients,of which 501 patients received XLS combined with mesalazine while 489 patients received mesalazine *** meta-analysis showed that,in terms of efficacy,the combination of XLS and mesalazine significantly improved the clinical efficacy rate by 22%[risk ratio(RR)=1.22;95%CI:1.15–1.28;Pmesalazine did not increase the occurrence of total and gastrointestinal adverse events,abdominal distension,and erythema(P>0.05).The TSA showed non conclusive findings in the meta-analysis of the safety ***’s test showed no publication bias(P=0.734).CONCLUSION Treatment with XLS alleviated the clinical symptoms,intestinal mucosal injury,and inflammatory response in patients with UC,while demonstrating good safety.

关键词： Xileisan mesalazine Ulcerative colitis Meta-analysis Trial sequential analysis

RETRACTED: Determination of the mesalazine Solubility at Biorelevant Temperature

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International Journal of Analytical Mass Spectrometry and Chromatography 2024年第1期12卷 1-12页

作者： Ekin Güler Kader Poturcu Elaheh Rahimpour Abolghasem Jouyban Faculty of Engineering and Natural Sciences Department of Chemistry Suleyman Demirel University Isparta Trkiye Pharmaceutical Analysis Research Center and Faculty of Pharmacy Tabriz University of Medical Sciences Tabriz Iran

Short Retraction NoticeThis article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".

关键词： mesalazine Solubility Shake-Flask Method Biorelevant Temperature XRD

Clinical Efficacy on the Treatment of Chronic Colitis with Feng-Liao-Chang-Wei-Kang Granules Combined with mesalazine

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Medicinal Plant 2022年第3期13卷 53-55页

作者： Kun NIU Daozhuang LIN Xian WANG Ling HUANG Fan YANG Hainan Medical University Haikou 571199China Qionghai Hospital of Traditional Chinese Medicine Qionghai 571400 China School of Hainan Provincial Drug Safety Evaluation Research Center Haikou 571199 China

[Objectives]To analyze the clinical effect of Feng-Liao-Chang-Wei-Kang Granule combined with mesalazine on chronic colitis.[Methods]120 patients with chronic enteritis admitted to Qionghai Hospital of Traditional Chinese Medicine from October 2020 to March 2022 were selected as the research objects,and were randomly divided into combined group(62 cases)and conventional group(58 cases).Patients in the conventional group were treated with oral mesalazine on the basis of conventional treatment,while patients in the combined group were treated with Feng-Liao-Chang-Wei-Kang Granule combined with *** clinical efficacy,inflammatory factor level,colonic mucosal lesion degree,quality of life and TCM syndrome scores of the two groups were compared.[Results]The total clinical effective rate in the combined group was higher than that in the conventional group(Pmesalazine can obviously improve the curative effect,reduce the level of inflammatory factors,improve the degree of colonic mucosal lesions and improve the quality of life of patients with chronic colitis,which is worthy of popularization and application in clinical practice.

关键词： Feng-Liao-Chang-Wei-Kang Granule mesalazine Chronic colitis Curative effect

Use of the ulcerative colitis endoscopic index of severity and Mayo endoscopic score for predicting the therapeutic effect of mesalazine in patients with ulcerative colitis

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第2期4卷 33-39页

作者： Haotian Chen Lexi Wu Mengyu Wang Bule Shao Lingna Ye Yu Zhang Qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Inflammatory Bowel Disease Center Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Objective:The ulcerative colitis endoscopic index of severity(UCEIS)and the Mayo endoscopic score(MES)are developed as objective methods of evaluating endoscopic severity in patients with ulcerative colitis(UC).The aim of this study is to investigate the diagnostic accuracy of the UCEIS and MES in predicting the patient's response to ***:Consecutive patients with UC who had undergone colonoscopy within 1 month before starting mesalazine between October 2011 and July 2016 were retrospectively collected at the Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of *** median follow-up was 81 months,and all the data were analyzed in January *** primary outcome was the need for step-up treatment,which included the use of corticosteroids,immunomodulatory,or surgery during admission and *** were analyzed using the c2 or Fisher exact test,Spearman test,t-test,and ManneWhitney U ***:Totally,65 patients were enrolled,of whom 12(18.5%)needed step-up treatment due to nonresponse to *** UCEIS score,MES,and the ulcerative colitis disease activity index(UCDAI)score were significantly higher in patients who had nonresponse to mesalazine(UCEIS score:6.92±0.69 vs.4.45±1.17,p<0.001;MES:2.67±0.49 vs.2.15±0.69,p=0.024;UCDAI score:9.33±1.87 vs.6.70±2.38,p=0.002).In the multivariate analysis,the UCEIS score(OR=25.65,95%CI:3.048 e45.985,p=0.003),UCDAI score(OR=1.605,95%CI:1.144e2.254,p=0.006),and C-reactive protein level(OR=1.056,95%CI:1.006e1.108,p=0.026)were independent risk factors of *** area under the ROC curve of UCEIS was 0.95,with a sensitivity of 100%and specificity of 84.6%,a cut-off value of 6,which outperformed the MES with an area under the ROC curve of *** the UCEIS score≥6,60%of patients eventually needed step-up ***:The UCEIS is a useful instrument for predicting the therapeutic effect in patients with UC treated with *** high probabili

关键词： mesalazine Ulcerative colitis Ulcerative colitis endoscopic index of severity Mayo endoscopic score Ulcerative colitis disease activity index

Clinical observation of Baitou Weng Decoction combined with mesalazine sustained-release tablets in treating heat-toxic and smoldering ulcerative colitis

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Journal of Hainan Medical University 2019年第12期25卷 37-42页

作者： Qian-Zhang Ma Yun Li Yuan-Quan Ding Department of Spleen and Stomach Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000LiaoningChina General Department of Medicine Tacheng District People's HospitalXinjiang Uygur Autonomous Region834700China Fujia Village Dalian SanatoriumShenyang Military RegionDalian116000LiaoningChina

Objective:To observe the clinical efficacy of Baitou Weng Decoction combined with mesalazine sustained-release tablets in the treatment of ulcerative colitis with febrile heat and its effect on immune function and serum inflammatory ***: A total of 84 patients with ulcerative colitis were randomly divided into control group and treatment group, with 42 cases in each group. The control group was given mesalazine sustained-release tablets orally, while the treatment group was given Baitou Weng Decoction and mesalazine sustained-release tablets orally. The treatment period was 30 days and the patients were followed up for 3 months. After treatment, the clinical efficacy, quality of life, immune function and serum inflammatory factors of the two groups were ***: The effective rate of treatment group (90.47%) was higher than that of control group (73.81%) (Pmesalazine in the treatment of heat-toxic and incandescent ulcerative colitis can significantly improve the clinical efficacy, improve the quality of life of patients, effectively regulate the expression level of serum inflammatory factors in ulcerative colitis patients, promote the recovery of patients' immune function, and have high drug safety

关键词： Baitou Weng Decoction mesalazine sustained-release tablets Hot toxicity Ulcerative colitis Immune function Serum inflammatory factor

Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy

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World Journal of Gastroenterology 2013年第6期19卷 889-896页

作者： István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth Department of Gastroenterology Petz Aladár County and Teaching Hospital Department of Mathematics and Computational Sciences Széchenyi István University

AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 *** Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal *** patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were *** with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the *** this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d *** the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS *** primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine ***:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one *** patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two *** patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was *** comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-t

关键词： Nonsteroidal anti-inflammatory drug Small bowel enteropathy mesalazine granules Mucosal healing Capsule endoscopy

Proposed case of mesalazine-induced cardiomyopathy in severe ulcerative colitis

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World Journal of Gastroenterology 2015年第11期21卷 3376-3379页

作者： Kathryn Fleming Andrew Ashcroft Christopher Alexakis Demitrios Tzias Christopher Groves Andrew Poullis Department of Gastroenterology St Georges Hospital

Five-amino salicylic acids are recommended for use in the management of inflammatory bowel disease,cardiac complications are a rare although recognised *** report aims to highlight this serious but rare adverse *** report here a case of a young man presenting with cardiogenic shock in the context of recent mesalazine treatment in severe ulcerative colitis.

关键词： Ulcerative colitis mesalazine Cardiomy-opathy Adve

Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity

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World Journal of Gastroenterology 2015年第13期21卷 4069-4077页

作者： José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra Department of Gastroenterology Central University Hospital of Asturias33011 OviedoAsturiasSpain Department of Internal Medicine Central University Hospital of Asturias33011 OviedoAsturiasSpain

mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease.

关键词： Eosinophilia mesalazine Pericardial effusion Lung

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溃疡性大肠炎治疗剂mesalazine

国外新药介绍 1997年第1期 26-29页