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Facial merkel cell carcinoma in a patient with diabetes and hepatitis B:A case report

World Journal of Clinical Cases 2023年第17期11卷 4179-4186页

作者： Ming-Yang Ren Yun-Juan Shi Wei Lu Sha-Sha Fan Xiao-Hua Tao Yang Ding School of Medicine Graduate School of Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Center for Plastic and Reconstructive Surgery Department of DermatologyZhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Patients with chronic inflammatory disorders are at a higher risk of developing aggressive merkel cell carcinoma(MCC). Diabetes is a common chronic inflammatory disease that is possibly associated with MCC;however, there are still no reports on the association between hepatitis B virus(HBV) infection and MCC. Whether there is an association between these three diseases and the specific mechanisms behind their effects is worth further research in the *** SUMMARY We herein report a rare case of MCC with extracutaneous and nodal invasion in an Asian individual with type 2 diabetes mellitus and chronic HBV infection, but no immunosuppression or other malignancies. Such cases are uncommon and have rarely been reported in the literature. A 56-year-old Asian male presented with a significant mass on his right cheek and underwent extensive resection combined with parotidectomy, neck lymphadenectomy, and split-thickness skin grafting. Based on the histopathological findings, a diagnosis of MCC involving the adipose tissue, muscle, nerve, and parotid gland with lymphovascular invasion was made. Subsequently, he received radiotherapy with no adverse *** MCC is a rare, aggressive skin cancer with frequent local recurrence, nodal invasion, and metastasis, which usually arises in older people of the white race. Patients with chronic inflammatory disorders are at a higher risk of developing aggressive MCC. The diagnosis can be confirmed with histology and immunohistochemistry. For localized MCC, surgery is the preferred treatment option. However, for advanced MCC, radiotherapy and chemotherapy have proven to be effective. In cases where chemotherapy is not effective or in the advanced stages of MCC, immune therapy plays an important role in treatment. As with any rare disease, the management of MCC remains an enormous challenge for clinicians;thus, follow-up should be individualized and future progress needs multidisciplinary collaborative effor

关键词： merkel cell carcinoma Diabetes Hepatitis B virus infection Case report

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Concurrence of merkel cell carcinoma and Squamous cell carcinoma in A Patient with Generalized Actinic Keratosis: A Case Report

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International Journal of Dermatology and Venereology 2022年第1期5卷 53-55页

作者： Zhang-Hui Yue Yan Wang Fang Fang Jian-Fang Sun Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatologic Surgery Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Introduction:merkel cell carcinoma(MCC)is a rare,aggressive cutaneous malignancy,and its pathogenesis might relate to ultraviolet light and merkel cell polyomavirus *** in the Chinese population is ***,we present a case of MCC that occurred based on widespread actinic keratosis(AK)in a Chinese *** report:An 82-year-old woman presented with two rapidly enlarging and rupture lesions on the face for 1 *** was suggestive of squamous cell carcinoma(SCC)on the forehead and MCC on the left *** patient had a history of generalized AK for 3 *** lesion on the left cheek was also revealed as an AK by histopathological examination 1 year *** surgical resection was performed to remove the two ***:The co-occurrence of AK,SCC,and MCC in a Chinese woman is *** examination is vital for correct *** three tumors,in this case,may originate from two different precursor cells and are affected by the same ***,they may come from the same pluripotent epidermal stem cells,and chronic exposure to ultraviolet light and merkel cell polyomavirus lead to the formation of different types of *** coexist of MCC with other cutaneous tumors provided a train of thought for exploring the origin of ***:We reported a rare co-existence phenomenon of MCC associated with AK and ***,long-term follow-up and early treatment are imperative for patients with premalignant lesions,such as widespread AK.

关键词： merkel cell carcinoma squamous cell carcinoma actinic keratosis concurrence case report

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Long-term response to avelumab and management of oligoprogression in merkel cell carcinoma:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4829-4836页

作者： Inês Leão Joana Marinho Telma Costa Department of Oncology Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

BACKGROUND merkel cell carcinoma(MCC)is a rare and aggressive cutaneous neuroendocrine neoplasia,with high risk of recurrence and metastasis and poor *** checkpoint inhibitors,like the anti-programmed death-ligand 1 agent avelumab,were recently approved for the treatment of advanced ***,herein,report the first case of advanced MCC with oligoprogression managed with avelumab and local radical *** SUMMARY A 61-year-old man was presented to the hospital with sporadic fever and an exudative malodorous mass(10 cm of diameter),located on the right gluteal *** final diagnosis was MCC,cT4N3M1c(AJCC,TNM staging 8th edition,2017),with invasion of adjacent muscle,in-transit metastasis,and bone *** started chemotherapy(cisplatin and etoposide),and after six cycles,the main tumor increased,evidencing disease *** months later,the patient started second line treatment with avelumab(under an early access program).After two cycles of treatment,the lesion started to decrease,achieving a major *** progression was documented after 16 ***,as the tumor became resectable,salvage surgery was performed,while keeping the systemic treatment with *** the patient developed bilateral pneumonia,immunotherapy was *** than 2.5 years after surgery(last 19 mo without systemic therapy),the patient maintains complete local response and stable bone *** This report highlights the efficacy and long-term response of avelumab on the management of a chemotherapy resistant advanced MCC,with evidence of oligoprogression,in combination with local radical treatment.

关键词： merkel cell carcinoma Unresectable tumor Avelumab Oligoprogression Surgery Chemotherapy Case report

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merkel cell carcinoma responsive to Etoposide:a case report and brief literature review

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 310-312页

作者： Chiara Ancona Andrea Caff Giovanni Manfredi Assanto Stefano Cordio Department of Medical Oncology Policlinico P.GiacconeUniversity of PalermoVia del Vespro 12990127 PalermoItaly Endocrinology Department of Clinical and Experimental MedicineGaribaldi-Nesima Medical CenterUniversity of CataniaVia Palermo 63695122 CataniaItaly Department of Oncology Garibaldi-Nesima Medical CenterUniversity of CataniaVia Palermo 63695122 CataniaItaly

merkel cell carcinoma(MCC),first described in 1972,is an aggressive primary cutaneous carcinoma able to incorporate both epithelial and neuroendocrine *** mainly appears in individuals in their eighth decade and it is related to a high mortality *** etiology of this rare disease is not well-understood but ultraviolet radiation exposure,immune suppression,and aging have a consistent role in its ***,clinical lesions appear as asymptomatic coloured dermal *** tumour can involve lymph nodes but further evaluation with imaging is *** common approach for localized disease is *** work reports a case of an 86-year-old man with locally advanced MCC where,based on clinical experience,oral mono-chemotherapy with single-agent etoposide was chosen as first-line therapy.A complete objective response was achieved in 2 months.

关键词： merkel cell carcinoma neuroendocrine chemotherapy etoposide

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Neuroendocrine tumors:current therapies,notch signaling,and cancer stem cells

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 279-293页

作者： Judy S.Crabtree Lucio Miele Department of Genetics and Stanley S.Scott Cancer Center Louisiana State University Health Sciences CenterNew OrleansLA 70112USA

Neuroendocrine tumors(NETs)encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage,affecting many different organs including the gastrointestinal(GI)tract,the endocrine pancreas,the thyroid,the skin and the respiratory *** tumors as a group are very heterogeneous,with varying characteristics attributed to each tissue of origin and tumor *** pathogenesis of the different subtypes of NETs is not fully understood,but recent studies suggest the Notch signaling pathway may be dysregulated in these tumors either by under or overexpression of Notch receptors and/or ligands,or by disruption of pathway functionality through other *** receptors can function as tumor suppressors in some cellular contexts and oncogenes in others which may,in part,account for the wide range of phenotypes present in *** stem cells are present in these tumors and may be responsible for the high rate of chemotherapy resistance,recurrence and *** heterogeneity of NETs suggests that to fully understand the role of Notch signaling and the therapeutic implications thereof,a comprehensive and systematic analysis of Notch expression and function across all NET subtypes is *** we outline the current knowledge base with respect to current therapies and Notch signaling in neuroendocrine tumors of the lung,skin,thyroid,GI tract and endocrine pancreas.

关键词： Neuroendocrine tumor Notch small cell lung carcinoma medullary thyroid carcinoma merkel cell carcinoma pancreatic NET carcinoid

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An update of Viral Association of Human Cancers

An update of Viral Association of Human Cancers

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新发传染病研究热点研讨会

作者： Ingemar Ernberg Departments of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholmSweden

Up to now,seven viruses that infect humans have been identified as oncogenic and are closely associated with different human *** encode for oncogenes whose products play important role in the context of environmental and genetic fector interaction,in the genesis of *** activities of the oncogenic viruses are reminiscent of the acute transforming retroviral tumorigenicity and in vivo correlate of the efficient immortalization by a lyphotropic herpesvirus,Epstein-Barr virus,albeit that the genesis of malignancy takes much longer *** occurrence of cancer is a complicated event involving multiple factors,from the host and the *** an individual factor among them exerts limited effect in the carcinogenic process,vaccination against the viral pathogen showed efficacy in preventing the spread of some viruses and in turn the development of some types of *** laboratory technique would facilitate the identification of new emerging viruses associated with malignancies indicated by epidemiologic and clinical data.

关键词： tumorigenesis oncogenic virus polyomavirus merkel cell carcinoma

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