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Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion

World Journal of Stem cells 2020年第5期12卷 368-380页

作者： Qi-Yuan Chang Si-Wen Zhang Ping-Ping Li Zheng-Wei Yuan Ji-Chun Tan Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province Shenyang 110004Liaoning ProvinceChina Key Laboratory of Health Ministry for Congenital Malformation Shengjing Hospital of China Medical UniversityBenxi 117004Liaoning ProvinceChina

BACKGROUND Intrauterine adhesion(IUA)can cause serious damage to women’s reproductive health,yet current treatment methods are difficult to achieve satisfactory *** our previous studies,we demonstrated that menstrual-derived stromal stem cells(MenSCs),with high proliferative capacity and self-renewal ability,have a powerful therapeutic effect in patients with severe ***,safety assessment of MenSCs transplantation is essential for its further *** To evaluate the short-,medium-,and long-term biosafety of MenSCs via intrauterine transplantation in a rat model of IUA,with a focus on toxicity and *** MenSCs were injected into the sub-serosal layer of the uterus in an IUA rat model,for 3 d,3 mo,and 6 mo separately,to monitor the corresponding acute,sub-chronic,and chronic *** rats of the same age served as negative *** effects were evaluated by body weight,organ weight,histopathology,hematology,and biochemistry *** of MenSCs was investigated in Balb/c-nu mice in vivo and by colony formation assays in *** Compared with the same week-old control group,all of the IUA rats receiving MenSC transplantation demonstrated no obvious changes in body weight,mainorgan weight,or blood cell composition during the acute,sub-chronic,and chronic observation *** the same time,serum biochemical tests showed no adverse effects on metabolism or liver and kidney *** 4 wk of subcutaneous injection of Men SCs in Balb/c-nu nude mice,no tumor formation or cell metastasis was ***,there was no tumor colony formation of Men SCs during soft agar culture in *** There is no acute,sub-chronic,or chronic poisoning,infection,tumorigenesis,or endometriosis in rats with IUA after Men SC *** above results suggest that intrauterine transplantation of Men SCs is safe for endometrial treatment.

关键词： menstrual blood-derived stromal cells Endometrial treatment Intrauterine adhesion Stem cell transplantation Biosafety Toxicity

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