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Expression of Integrin-α_3 mRNA in meningiomas and Its Correlation with Proliferation and Invasion

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第1期29卷 94-96页

作者：陈坚许先平王和平 Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

To investigate the expression of integrin-α3 mRNA in meningiomas and its correlation with proliferation and invasion, the expression of integrin-α3 subunit was detected by using in situ hybridization in patients with meningiomas （36 cases） and normal dura （2 cases） and arachnoid tis- sues （2 cases）. SABC immunohistochemical assay was used to study the expression of Ki-67 nuclear antigen. The results showed that the expression of integrin-% mRNA in benign, atypical and malig- nant meningiomas was 2.52±0.362, 1.75±0.316 and 1.42±0.633, respectively. The expression levels of integrin-α3 mRNA was significantly lower in atypical or malignant meningiomas than those in benign meningiomas （P〈0.05, P〈0,01, respectively）. The expression of integrin-α3 mRNA in those with invasive biological behavior was lower than that in those without invasion （1.63±0.462 vs. 2.61±0.526, P〈0.01）. Moreover, the expression of integrin-α3 mRNA was inversely associated with Ki-67 labeling index in all cases. It suggested that integfin-α3 subunit participated in the modulatory process of growth of meningiomas. The proliferation activity and malignant grade of meningiomas were increased with the decreased expression of integrin-α3 subunit, and the down-regulation of integrin-α3 mRNA was associated with the invasive biological behaviors in meningiomas.

关键词： integrins meningiomas Ki-67 in situ hybridization immunohistochistochemistry

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Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 in Human meningiomas

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第1期25卷 75-77页

作者：易伟陈坚 Filimon H. Golwa 薛德麟 Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. The tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.

关键词： meningiomas basic fibroblast growth factor fibroblast growth factor receptor-1 microvascular density immunohistochemistry

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Tuberculum Sellae meningiomas: Nuances in Treatment

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Open Journal of Modern Neurosurgery 2019年第3期9卷 227-236页

作者： Mohamed Khallaf Department of Neurosurgery Faculty of Medicine Assiut University Assiut Egypt

Tuberculum sellae meningiomas (TSMs) represent special surgical challenge for neurosurgeons. In this review, we summarize the most common clinical manifestations, diagnostic images, surgical approaches and prognostic factors for outcome at single tertiary care teaching hospitals. Material and Methods: Prospective study was done between January 2010 and January 2017 (Minimum 24-month follow-up). Imaging and clinical data of 31 consecutive patients with TSMs were collected and analyzed. There were no exclusion criteria. Result: The majority of patients were >40 years old (22 patients;71%). There was a female preponderance 74%: 23 cases (M/F ratio was 1:3). The most common clinical presentation was visual impairment (24;77%). The mean tumor size was 3.3 cm. Thirty-one patients underwent surgical excision by different approaches. The overall visual improvement was 29% (9 of 31 patients) however visual deterioration occurred in 6.4% (2 of 31 patients). Favorable prognosis was found in patients with short preoperative visual affection (less than 6 months). This finding was statistically significant (P ≤ 0.05). Also, visual outcome had significant correlations with edema surrounded tumor: arterial encasement by the tumor and brain-tumor interface. Two patients died 3 weeks postoperatively from brain stem infarction (overall incidence of mortality 6%) while the overall incidence of morbidity was 19% (6 of 31 patients). Conclusion: The most common symptom of Tuberculum sellae meningioma is visual affection. The favorable prognosis was found in patients with short preoperative visual affection (less than 6 months). Also;visual prognosis had significant correlations with peritumoral edema, arterial encasement by the tumor, and brain-tumor interface.

关键词： Tuberculum Sellae meningiomas Optic Nerve Visual Outcome Surgical Approaches

Ultrastructural Study of meningiomas

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Journal of Medical Colleges of PLA 1986年第3期 265-269页

作者：罗深秋张义勋 Electron Microscope Laboratory First Military Medical College Guangzhou Department of Pathology

8 specimens of meningioma(4 meningotheliomatous,3 fibrousand 1 transitional)were observed with transmission electron micro-scope(TEM).The main feature of most tumor cells is that there aremany conspicuous interdigitations of cytoplasm protruding outfrom the cell *** are a lot of mitochondria,Golgi com-plexes and microfilaments which are closely packed or scatteredinside the *** the interdigitations,many des-mosomes are *** meningiomas have an epithelioid *** may explain why the tumors cells would not scatter outwhen the smear samples or histological sections are observed underlight *** three types of meningiomas described inthe present work may mainly originate from epithelioid cells ofarachnoid granulations as inferred from the ultrastructure *** did not find any distinct differences in the ultrastructuresamong them.

关键词： meningiomas cytoplasmic processes of meningiomas desmosomes microfilaments

Dural lesions mimicking meningiomas:A pictorial essay

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World Journal of Radiology 2012年第3期4卷 75-82页

作者： Danai Chourmouzi Stamatia Potsi Anestis Moumtzouoglou Elisavet Papadopoulou Kostas Drevelegas Thomas Zaraboukas Antonios Drevelegas Department of Radiology Interbalkan Medical Center Department of Pathology Aristotle University Medical School of Thessaloniki Department of Radiology AHEPA University HospitalAristotle University Medical School of Thessaloniki

The purpose of this essay was to illustrate the radiological and pathological findings in a wide spectrum of dural lesions mimicking *** with and knowledge of these findings will narrow the differential diagnosis and provide guidance for patient *** this pictorial review,we describe the following entities:Solitary fibrous tumors,hemangiopericytoma,gliosarcoma,leiomyosarcoma,dural metastases,Hodgkin’s disease,plasmocytoma,Rosai-Dorfman disease,neurosarcoidosis,melanocytic neoplasms and plasma cell granuloma.

关键词： Differential diagnosis Dural lesions Imaging meningiomas

Surgical management of clinoidal meningiomas: 10 cases analysis

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Neuroimmunology and Neuroinflammation 2018年第5期5卷 21-30页

作者： Shamsul Alam Bipin Kumar Chaurasia Narendra Shalike Abu Naim Wakil Uddin Dhiman Chowdhury Akhlaque Hossain Khan Ayub Ansari Kanak Kanti Barua Mashiur Rahman Majumder Department of Neurosurgery Bangabandhu Sheikh Mujib Medical UniversityDhaka1000Bangladesh Department of Neurosurgery Comilla Medical CollegeComilla3500Bangladesh

Aim: The purpose of this article is to advocate standard skull base technique for removing the clinoidal meningioma and to delineate the technique's advantages that aid in achieving an improved extent of tumor resection and enhancing the patients' overall outcome, specially their visual outcome. Methods: A retrospective analysis was performed on 10 consecutive patients with clinoidal meningiomas who underwent surgical resection at the Bangabandhu Sheikh Mujib Medical University and other private clinics between May 2013 and July 2016. A standard pterional craniotomy technique consisting of extradural anterior clinoidectomy, coupled with optic canal unroofing and optic nerve sheath opening was used in all patients. All patients had thorough preoperative and postoperative ophthalmological evaluations. The follow-up period ranged from 6 to 42 months. Results: Total resection was achieved in 5 (50.0%) of the 10 patients in this series. The majority of the patients with preoperative visual impairment experienced significant visual improvement 7 of 10 patients;70.0%). Conclusion: In the majority of patients with clinoidal meningiomas, total resection may be achieved with minimal complications. For large tumors encasing the optic nerve and internal carotid artery, or for those tumors causing preoperative visual impairment, use of the cranial base technique delineated in this study may lead to significant improvement in the patients' visual and overall outcomes.

关键词： Clinoidal meningiomas pterional craniotomy extradural anterior clinoidectomy

The causal relationship betweengenetically determined telomerelength and meningiomas risk

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The causal relationship betweengenetically determined telome...

Somatic mutation landscape of a meningioma and its pulmonary metastasis

第十八届中国医师协会神经外科医师年会

作者：陈四方王占祥厦门大学附属第一医院

目的 Studies have shown that longer leukocyte telomere length(LTL)is significantly associated with increased risk of ***,thereis limited evidence concerning the causal association of LTL with benign andmalignant meningiomas or with the location of benign tumors.方法 We used three LTL datasets from different sources,designated byname and sample size as LTL-78592,LTL-9190,and *** linkagedisequilibrium score (LDSC) was used to explore the association between LTLand meningioma.结果 In the LTL-78592,longer LTL was significantly associated with increasedrisk of malignant,benign (OR=4.81,pmeningiomas,regardless of the LTLmeasure,in European populations.

关键词： Mendelian randomization meningiomas telomere length causality risk

来源： cnki会议评论

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Cancer Communications 2018年第1期38卷 188-194页

作者： Yaran Du Ting Lu Song Huang Fangfang Ren Gang Cui Jian Chen Institute of Functional Nano and Soft Materials(FUNSOM)&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215123P.R.China Department of Neurosurgery First Affiliated Hospital of Soochow UniversitySuzhou 215006P.R.China National Institute of Biological Sciences Beijing 102206P.R.China Department of Biochemistry and Molecular Biology Soochow University Medical CollegeSuzhou 215123P.R.China

Background:Extracranial metastasis(ENM)of meningiomas is extremely rare,and typically occurs several years after a primary tumor is ***,the genetic changes underlying ENM events have not yet been *** presentation:A 58-year-old male patient was sent to the emergency room of our hospital because of a sudden *** resonance imaging detected a mass at the right frontal sagittal *** underwent tumor resection and recovered well,but post-operative computed tomography revealed three lumps on the right side of his *** surgery was performed to remove two of the *** findings revealed that the brain and lung tumors were grade I *** patient received no additional radiation or chemotherapy post-surgery,and there was no sign of tumor recurrence in the brain or progression of the remaining lump in the chest 1 year after *** performed whole exome sequencing of the patient’s blood,primary brain tumor,and lung metastatic tumor tissues to identify somatic genetic alterations that had occurred during *** revealed that a frameshift deletion of the neurofibromin 2 gene likely drove formation of the ***,we found that the brain tumor was relatively homogeneous and contained only one dominant clone;both the pulmonary metastasis and the original brain tumor were derived from the same clone,and no obvious additional driver mutations were detected in the metastatic ***:Although ENM of meningiomas is very rare,brain tumor cells appear to be more adaptable to tissue microenvironments outside of the central nervous system than was commonly thought.

关键词： meningiomas Extracranial metastasis Whole exome sequencing Neurofibromin 2

Management and Diagnosis Challenges in Cystic Meningioma. A Case Report and Review of Literature

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Open Journal of Modern Neurosurgery 2020年第2期10卷 222-229页

作者： Mustapha Hemama Nourou Dine Adeniran Bankole Moussa Denou Kaoutar Znati Nizare El Fatemi Moulay Rachid El Maquili Neurosurgery Department Ibn Sina Hospital Rabat Morocco Mohammed V University Rabat Morocco Neuroanatomopathology Department Ibn Sina Hospital Rabat Morocco

Background: Cystic meningioma is a rare variety of meningioma. It represents 4% to 7% of all meningiomas. The authors report a case of intracranial cystic meningioma with a review of literature. Case Report: A 59-year-old female presented with a history of headache followed by left side hemiplegia. CT scan and MRI of the brain showed a right parietal tumor with double solid and cystic components thought to be pilocytic astrocytoma or metastasis preoperatively. At surgery, the extraaxial solid and cystic lesion had a well defined capsule that could be easily separated from the perilesional cortical surface. The tumor was totally removed and the cyst was punctioned. The histological study showed a cystic meningioma WHO Grade I. A follow-up at 10 months after surgery, the patient was going well and recovered from the hemiplegiaa. Conclusion: Cystic meningioma is an uncommon tumor that should be considered in the differential diagnosis of brain tumors with a cystic component. The preoperative diagnosis and management could be in some cases challenging.

关键词： meningiomas Cyst Differential Diagnosis Case Report