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saccades of video head impulse test in meniere's disease and Vestibular Migraine: What can we learn from?

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Journal of Otology 2023年第2期18卷 79-84页

作者： Yi Du Xingjian Liu Lili Ren Yu Wang Fei Ji Weiwei Guo Ziming Wu College of Otolaryngology Head and Neck surgery Chinese PLA General HospitalChinese PLA Medical School28 Fuxing RoadBeijingChina National Clinical Research Center for Otolaryngologic diseases BeijingChina state Key Lab of Hearing science Ministry of EducationBeijingChina Beijing Key Lab of Hearing Impairment Prevention and Treatment BeijingChina

Background:saccades are often observed on video head impulse tests(vHIT)in patients with meniere's disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully ***:This study aims to identify the saccades characteristics of MD and ***:75 VM patients and 103 definite unilateral MD patients were enrolled in this *** raw saccades were exported and *** VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and ***:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic *** MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected ***:Bilateral saccades are commonly observed in MD and *** contrast to MD,saccades on VM are subtle,scattered,and ***,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.

关键词： meniere's disease Vestibular migraine saccades Video head impulse test Differential diagnosis

Dexamethasone does not affect endolymphatic hydrops(EH)in patients with meniere's disease within 24 h,and intratympanic administration of gadolinium plus dexamethasone simplifies high-quality imaging of EH using a novel protocol of 7 min

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Journal of Otology 2022年第3期17卷 164-174页

作者： Jing Zou Zikai Zhao Hongbin Li Guoping Zhang Qing Zhang Jianping Lu Ilmari Pyykko Department of Otolaryngology-Head and Neck surgery Changhai HospitalSecond Military Medical UniversityShanghaiChina Department of Radiology Changhai HospitalSecond Military Medical UniversityShanghaiChina Faculty of Information Technology and Communication sciences Tampere UniversityTampereFinland Hearing and Balance Research Unit Field of OtolaryngologySchool of MedicineFaculty of Medicine and Health TechnologyTampere UniversityTampereFinland

Background:Intratympanic administration of gadolinium chelate allows for a better visualization of endolymphatic hydrops(EH)using MRI than intravenous injection and was recently further improved to facilitate high-quality imaging of EH in 7 *** aim of the present study was to simplify the intratympanic administration protocol by mixing gadolinium chelate with therapeutic dexamethasone and to evaluate the effects of this mixture on the visualization of EH in *** and methods:In an in vitro study,the potential impact of gadolinium-diethylenetriamine pentaacetic acid(Gd-DTPA)on the stability of dexamethasone was evaluated by analyzing dynamic changes in dexamethasone with high-performance liquid chromatography(HPLC)after mixing with *** patients with definite meniere's disease(MD)were recruited to study the potential interference of dexamethasone on MRI visualization of EH,and 49 patients with MD were recruited to evaluate the effect of intratympanic injection of Gd-DTPA mixed with dexamethasone on MRI of EH using a 3T MR machine and a novel heavily T2-weighted 3-dimensional fluid-attenuated inversion recovery reconstructed using a magnitude plus zero-filled interpolation(hT2FLAIR-MZFI)***:The retention times and peak area of dexamethasone in HPLC were not modified by the addition of *** grading in the cochlea and vestibule was not influenced in any ear by intratympanic injection of *** inner ear images were obtained from all patients,and EHs with various grades were *** were significant correlations between diagnosis and cochlear EH(pspearman's Rho),between diagnosis and vestibular EH(pspearman's Rho),and between cochlear and vestibular EH(pspearman's Rho).The distribution of Gd-DTPA plus dexamethasone negatively correlated with the grade of vestibular *** of the endolymph-perilymph barrier was detected in one cochlea and three vestibules of 59 inner ears with ***

关键词： meniere's disease Endolymphatic hydrops MRI Contrast agent Therapeutics Topical administration

MEFV,IRF8,ADA,PEPD,and NBAs gene variants and elevated serum cytokines in a patient with unilateral sporadic meniere's disease and vascular congestion over the endolymphatic sac

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Journal of Otology 2022年第3期17卷 175-181页

作者： Jing Zou Zikai Zhao Guoping Zhang Qing Zhang Ilmari Pyykko Department of Otolaryngology-Head and Neck surgery Changhai HospitalSecond Military Medical UniversityShanghaiChina Faculty of Information Technology and Communication sciences Tampere UniversityTampereFinland Hearing and Balance Research Unit Field of OtolaryngologySchool of MedicineFaculty of Medicine and Health TechnologyTampere UniversityTampereFinland

The etiology and underlying mechanism of meniere's disease(MD)development are still unknown,although inflammation and autoimmunity have been implicated as underlying *** human endolymphatic sac(Es)has been reported to have innate and adaptive immune capacity in local immune *** vivo demonstration of inflammation of the Es in patients with MD is missing in the *** report the case of a 47-year-old female patient diagnosed with unilateral MD with genetic variants and cytokine markers indicating inflammation and vascular congestion of the *** hydrops in the right cochlea(grade 2)and vestibulum(grade 3)were detected using *** carried heterozygous variants in MEFV(c.442G>C),IRF8(c.1157G>T),ADA(c.445C>T),PEPD(c.151G>A),NBAs(c.4049T>C),CsF2RB(c.2222C>T),HPs6(c.277G>T),IL2RB(c.1109C>T),IL12RB1(c.1384G>T),IL17RC(c.260_271del GCAAGAGC TGGG),LIG1(c.746G>A),RAG1(c.650C>A),and sLX4(c.1258G>C,c.5072A>G).In the serum,the levels of granulocyte colony-stimulating factor(G-CsF),macrophage inflammatory protein 1a,and IL7 were significantly elevated,and the level of IL2Ra was *** administration of dexamethasone temporarily alleviated her hearing *** vertigo was significantly relieved but remained slight after Es administration of corticosteroids.

关键词： meniere's disease Autoinflammation Autoimmune Immune organ Endolymphatic sac

A study of efficacy of Nigella sativa in treatment of meniere's disease: A randomized, placebo controlled clinical trial

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Journal of Otology 2023年第2期18卷 97-100页

作者： Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi Mona Zeinaloo Department of Cochlear Implant and Otorhinolaryngology Tehran University of Medical SciencesTehranIran Amir Alam Hospital Tehran University of Medical SciencesTehranIran Otorhinolaryngology Research Center Amir Alam HospitalTehran University of Medical SciencesTehranIran Otorhinolaryngology Research Center Tehran University of Medical SciencesTehranIran Department of Otorhinolaryngology and Head and Neck surgery Amir Alam HospitalTehran University of Medical SciencesTehranIran Department of Community Medicine Tehran University of Medical SciencesTehranIran

Purpose:meniere's disease(MD),first introduced by Prosper meniere,is characterized mainly by vertigo,tinnitus,aural fullness and sensorineural hearing *** the exact pathophysiology of MD is unknown,immunologic and inflammatory interactions are possible underlying mechanisms involved in *** study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic ***:We divided 40 patients with definite MD into two groups of 20 *** study group received 1 g of Nigella sativa oil daily for three months and the control group received a *** in hearing,tinnitus and vertigo were estimated by pure tone audiometry,tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire,***:At the end of the study we did not observe any significant improvement in study's group hearing threshold,tinnitus and vertigo compared to the control ***:In this study,statistical analysis showed that Nigella sativa failed to improve signs and symptoms of ***,further investigations with a larger study population are needed to ascertain the current conclusion.

关键词： meniere's disease Nigella sativa Tinnitus Vertigo Hearing loss

Characteristics of the Cochlear symptoms and Functions in meniere＇s disease

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Chinese Medical Journal 2016年第20期129卷 2445-2450页

作者： Yi Zhang Bo Liu Rui Wang Ruo Jia Xin Gu Department of Otolaryngology Head and Neck surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Institute of Otolaryngology Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University) Ministry of Education Beijing 100730 China

Background：meniere＇s disease is a unique,progressive disease of the inner *** complex manifestation presents diagnostic *** cochlear symptoms often present before vertigo and tend to be *** study aimed to analyze the characteristics of cochlear symptoms and functions associated with meniere＇s disease to investigate the regularity of the development of this ***：One-hundred fifteen patients who were diagnosed with definite unilateral meniere＇s disease at the Hearing and Vestibular Clinic of the Department of Otorhinolaryngology of Beijing Tongren Hospital from August 2013 to November 2015 were recruited in this retrospective *** symptoms,duration from initial symptoms to the diagnosis,hearing thresholds,audiogram patterns,and caloric test results were collected and analyzed for each *** were analyzed using sPss 13.0 statistical software by spearman＇s correlation,Kruskal-Wallis H test,Chi-square test,and Fisher＇s exact ***：The average hearing threshold of these patients was 45.24 ± 18.40 dB HL.A majority of the patients （55.65%） were in stage *** initial presentation of the disorder in 58 cases （50.43%） comprised only cochlear symptoms without vertigo.A weak,positive correlation was found between the degree of hearing loss and duration of the disease from initial symptoms to the diagnosis （rs =0.288,P =0.002）.Upward-sloping,inverted ＂V,＂ downward-sloping,and flat pattern were the main audiometric patterns observed with a distinctive distribution between stages （P 〈 0.001）.Based on the configurations of audiograms,the audiometric patterns had a weak correlation to the duration （rs =0.269,P =0.004）,and there was a tendency of duration to rising from upward-sloping,inverted ＂V＂,downward-sloping to flat pattern.（H =10.024,P =0.018）.Frequencies of tinnitus in 56 patients （64.4%） were at the lowest points of the audiograms,i.e.,the frequencies of the poorest hearing *** patients at an advanced stage

关键词： Caloric Test Hearing Loss meniere's disease Tinnitus Vertigo

study of cochlear hydrops analysis masking procedure in patients with meniere＇s disease and otologically normal adults

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Chinese Medical Journal 2012年第24期125卷 4449-4453页

作者： sHANG Ying-ying DIAO Wen-wen NI Dao-feng GAO Zhi-qiang XU Chun-xiao LI Feng-rong Department of Otorhinolaryngology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background The cochlear hydrops analysis masking procedure （CHAMP） is a new diagnostic technique for meniere＇s disease （MD）. But its value has not been well proven. This study aimed to evaluate the diagnostic value of CHAMP for MD. Methods CHAMP test was taken in three populations using the Auditory Evoked Potential system delivered by Bio-logic systems Corporation：（1） otologically normal subjects; （2） patients clinically diagnosed with definite MD; （3） patients clinically diagnosed with probable and possible MD. Results According to the comparison between the normal and definite MD group, if the abnormal criterion of CHAMP was defined as latency delay less than 0.3 ms, then the corresponding sensitivity was only 52%. However, if the abnormal criterion was defined as latency delay between 0.6 and 3.8 ms, then a sensitivity of 93% and a specificity of 100% can be achieved. The complex amplitude ratio showed a significant overlap between normal and definite MD group. If the abnormal criterion was defined as a complex amplitude ratio less than 0.95, the corresponding specificity was only 50%. However, if the abnormal cdtedon was defined as less than 0.80, the corresponding sensitivity was 60%, and the specificity was 97%. If the abnormal criterion of CHAMP was defined as latency delay less than 0.6 ms or the complex amplitude ratio less than 0.80, CHAMP result can be obtained in all subjects with good sensitivity and specificity. Conclusions CHAMP can differentiate patients with meniere＇s disease from otologically normal subjects with high sensitivity and specificity. The recommended cdterion of abnormal CHAMP was a latency delay less than 0.6 ms or a complex amplitude ratio less than 0.80.

关键词： auditory evoked potentials diagnostic techniques meniere's disease

MRI detection of endolymphatic hydrops in meniere's disease in 8 minutes using MIIRMR and a 20-channel coil after targeted gadolinium delivery

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World Journal of Otorhinolaryngology-Head and Neck surgery 2019年第4期5卷 180-187页

作者： Jing Zou Zhen Wang Yukun Chen Guoping Zhang Luguang Chen Jianping Lu Department of Otolaryngology-Head and Neck surgery Center for Otolaryngology-Head&Neck Surgery of Chinese PLAChanghai HospitalSecond Military Medical UniversityShanghaiChina Department of Radiology Changhai HospitalSecond Military Medical UniversityShanghaiChina

Background:Endolymphatic hydrops(EH)become visible in vertigo patients,particularly in those with meniere's disease(MD),in vivo using gadolinium-enhanced ***,the image quality is not satisfying after intravenous injection of gadolinium chelate(GdC),and occasional failure in GdC uptake has been noticed after traditional intratympanic *** the present report,targeted delivery of GdC and using a cost-effective MRI system to obtain high quality images of EH in only 8 min will be ***:39 MD patients were recruited in the ***,0.1 ml of 20-fold diluted gadolinium-diethylenetriamine acid(Gd-DTPA)was delivered onto the posterior upper part of the tympanic medial wall using a soft-tipped micro-irrigation catheter through an artificially perforated tympanic *** ear MRI was performed 24 h after Gd-DTPA administration using a 3T MR machine and a 20-channel head/neck coil with an 8 min sequence of medium inversion time inversion recovery imaging with magnitude reconstruction(MIIRMR).The parameters were as follows:TR 16000 ms,TE 663 ms,inversion time 2700 ms,flip angle 180°,slices per slab ***:Efficient inner ear uptake of Gd-DTPA was detected 24 h after delivery and it created excellent contrast in the inner ear of all *** quality images demonstrating EH in the vestibule and cochlea were ***:Targeted delivery of minimum Gd-DTPA(0.1 ml,20-fold dilution)onto the posterior upper portion of the tympanic medial wall and MRI with MIIRMR in a 3T machine and 20-channel head/neck coil are clinically practical to obtain high quality images displaying EH.

关键词： meniere's disease Endolymphatic hydrops MRI Drug delivery Targeting

Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy

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Journal of Otology 2024年第1期19卷 55-58页

作者： Jing Zou Department of Otolaryngology-Head and Neck surgery Changhai HospitalSecond Military Medical UniversityShanghai200433China Faculty of Information Technology and Communication sciences Tampere UniversityTampereFinland

The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of meniere’s disease (MD) and sudden sensorineural hearing loss (ssHL).Gelation occurred shortly after mixing dexamethasone-containing fibrinogen with *** was constantly released for at least 16 d at a stable level after 7d in protocol 1 (low-dose),while it was robustly released within 4 d and slowed afterward until 10 d in protocol 2(high-dose).There were significant differences among the time points in Protocol 2 (ps the *** estimated concentration of dexamethasone released on 7 d in protocol 2 was slightly lower than that observed in protocol *** fibrin sealant is capable of constantly releasing dexamethasone with adjustable *** and minimally invasive administration of the material can be achieved in the clinic by sequential injections of the fluids using a soft-tipped catheter.

关键词： Intratympanic drug delivery Controlled release Corticosteroids meniere's disease sudden sensorineural hearing loss

ILLUsTRATIVE CAsEs TREATED BY THE APPLICATION OF THE EXTRA POINT sIsHENCONG

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Journal of Traditional Chinese Medicine 1998年第2期18卷 111-114页

作者：刘和春 HospitalofscalpAcupunctureofTraditionalChineseMedicine WangjiangCountyAnhuiProvince.

The president of our hospital, Dr. Chen Daoyi, has rich experience in the clinical us age of sishencong (Extra 6). Having learnt from him, now Ⅰ present a few cases, in which the patients have been treated with this ... 详细信息

关键词： Acupuncture Points Acupuncture Therapy Adolescent Adult Child Child, Preschool Female Headache Humans Male meniere's disease Middle Aged schizophrenia