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Interaction Between memory load and Experimental Design on Brain Connectivity and Network Topology

Neuroscience Bulletin 2023年第4期39卷 631-644页

作者： Heming Zhang Xin Di Bart Rypma Hang Yang Chun Meng Bharat Biswal The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China Department of Biomedical Engineering New Jersey Institute of TechnologyNewark07102USA Department of Psychology University of Texas at DallasDallas75390USA

The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals of task activation.While providing many insights into brain functions,the block design adds more manipulation in functional network analysis that may reduce the purity of the blood oxygenation level-dependent signal.Recent studies utilized one single long run for task trials of the same condition,the so-called continuous design,to investigate functional connectivity based on task functional magnetic resonance imaging.Continuous brain activities associated with the single-task condition can be directly utilized for task-related functional connectivity assessment,which has been examined for working memory,sensory,motor,and semantic task experiments in previous research.But it remains unclear how the block and continuous design influence the assessment of task-related functional connectivity networks.This study aimed to disentangle the separable effects of block/continuous design and working memory load on task-related functional connectivity networks,by using repeated-measures analysis of variance.Across 50 young healthy adults,behavioral results of accuracy and reaction time showed a significant main effect of design as well as interaction between design and load.Imaging results revealed that the cingulo-opercular,fronto-parietal,and default model networks were associated with not only task activation,but significant main effects of design and load as well as their interaction on intra-and inter-network functional connectivity and global network topology.Moreover,a significant behavior-brain association was identified for the continuous design.This work has extended the evidence that continuous design can be used to study task-related functional connectivity and subtle brain-behavioral relationships.

关键词： Working memory Functional connectivity Network topology Block design Continuous design memory load

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