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Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory th/tfh subset balance

世界胃肠病学杂志:英文版 2023年第36期29卷 5226-5239页

作者： Lin-Xin Zheng Kai-En Guo Jia-Qi Huang Miao-Hua Liu Bai-Ling Deng Duan-Yong Liu Bu-Gao Zhou Wen Zhou You-Bao Zhong Hai-Mei Zhao Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina College of traditional Chinese Medicine Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Nanchang Medical College Nanchang 330052Jiangxi ProvinceChina Laboratory Animal Research Center for Science and technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Restoration of immune homeostasis by targeting the balance between memory t helper(mth)cells and memory follicular t helper(mtfh)cells is a potential therapeutic strategy against ulcerative colitis(UC).Because of its anti-inflammatory and immunomodulatory properties,curcumin(Cur)is a promising drug for UC ***,fewer studies have demonstrated whether Cur can modulate the mth/mtfh subset balance in mice with *** to explore the potential mechanism underlying Cur-mediated alleviation of colitis induced by dextran sulfate sodium(DSS)in mice by regulating the mth and mtfh immune *** Balb/c mice were administered 3%and 2%DSS to establish the UC model and treated with Cur(200 mg/kg/d)by gavage on days *** the 18th d,all mice were anesthetized and euthanized,and the colonic length,colonic weight,and colonic weight index were *** changes in the mouse colon were observed through hematoxylin-eosin *** of th/mth and tfh/mtfh cell subsets in the spleen were detected through flow *** blotting was performed to detect SOCS-1,SOCS-3,StAt3,p-StAt3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in colon *** Cur effectively mitigates DSS-induced colitis,facilitates the restoration of mouse weight and colonic length,and diminishes the colonic weight and colonic weight ***,it hinders ulcer development and inflammatory cell infiltration in the colonic mucous *** the percentage of th1,mth1,th7,mth7,th17,mth17,tfh1,mtfh1,tfh7,mtfh7,tfh17,and mtfh17 cells decreased after Cur treatment of the mice for 7 d,and the frequency of mth10,th10,mtfh10,and tfh10 cells in the mouse spleen *** studies revealed that Cur administration prominently decreased the SOCS-1,SOCS-3,StAt3,p-StAt3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in the colon *** Cur regulated the mth/mtfh cell homeostasis to reduce DSS-induced colonic pat

关键词： Curcumin Ulcerative colitis memory t helper memory follicular t helper JAK1/StAt3/SOCS

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