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Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance

Bioactive Materials 2023年第1期19卷 1-11页

作者： Haibao Peng Xingcai Zhang Peng Yang Jiaxu Zhao Wei Zhang Nianping Feng Wuli Yang Jing Tang Institute for Translational Brain Research Fudan UniversityShanghai200032China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Pharmaceutical Sciences Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Materials Science and Engineering Stanford UniversityStanfordCA94305United States School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States Engineering Research Center of Molecular-and Neuro-imaging of Ministry of Education School of Life Science and TechnologyXidian University710126China

The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of ***,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug ***,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant ***,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant *** and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis *** RBC membrane could camouflage the nanoplatform for longer *** results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer *** work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by *** defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential.

关键词： Metal-organic framework Defect nanostructures Ferroptosis membrane-camouflaged Multi-drug-delivery

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