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Application of memantine hydrochloride in depression-model rats

Application of memantine hydrochloride in depression-model r...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei-Na QUAN~1,Shuang LIANG~2,Tao ZHANG~2,Zhuo YANG~(1,*) 1 Laboratory of Neurophysiology,Medical School,Nankai University,Tianjin 300071,China 2 Laboratory of Bioinformatics,Life Science Institude,Nankai University,Tianjin 300071,China

＜正＞Objective This study was designed to establish an animal model of depression,and using physiological, behavioral and electrophysiological methods to explore the pathogenesis of depression and to assess possible antidepressant effects of memantine hydrochloride（hcl）,a selective N-methyl-D-aspartate（NMD A） antagonist,in this animal *** The animal model of depression was established in male Wistar rats by combining isolation rearing with chronic unpredictable mild stress（CUMS）.memantine hcl（20 mg/kg） was administered intraperitoneally from the second day of establishing depression model,for 21 d,until the first day of water maze *** rats’ physiological status was observed by their weights and sucrose *** change was observed by water maze *** change was tested by recording long-term potentiation（LTP） from thalamus to prefrontal *** （1） Compared with normal group,rats’ weight increase and sucrose consumption was statistically lower in CUMS model group and memantine hcl-treated group.（2） In the water maze test,the mean escape latency（EL） of the first period of Oriented Navigation Training（ONT） was significantly prolonged in CUMS model group and memantine hcl-treated group as compared with that of normal *** of the second and third periods of ONT was significantly prolonged in memantine hcl-treated group as compared with those of normal group and CUMS model group.（3） LTP test showed that excitatory postsynaptic potential（PSP） slopes were statistically different among three *** model group had the lowest slopes and normal group had the highest *** Animal model of depression can be established successfully by isolation rearing combined with chronic unpredicted mild *** a 21-d trial,memantine in the dose of 20 mg/kg was not effective in the treatment of depression,but it could improve synaptic plasticity in prefrontal cortex in model rats.

关键词： depression memantine hcl isolation rearing CUMS water maze LTP

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