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Medicinal Plant 2024年第5期15卷 90-95页

作者： Jia BAI Yingzhe LI Chunying ZHAO Chengde Medical University Hebei Key Laboratory of Research and Development of Traditional Chinese MedicineChengde 067000.China

The efficacy,application and compatibility of five kinds of Chinese Herbal medicines medicine(including yam,licorice,Platyc-odonisi Radix,Polygonati Rhizoma,and Pueraria Lobata)for medicine and food homology in the past five years were systematically searched and summarized,and the current situation of their food development was reviewed to provide theoretical basis for the research and development of this kind of CHMs for health care.

关键词： medicine and food homology Efficacy food development Rhizome traditional Chinese medicine

Understanding “medicine and food homology”,developing utilization in medicine functions

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Chinese Herbal medicines 2018年第4期10卷 337-338页

作者： Changxiao Liu

Chinese medicine is a very big concept of medicine. In Shennong era, medicine and food do not divide.＂medicine and food homology＂, which is called ＂Chinese medicine and dietary application＂, refers to that many fo... 详细信息

关键词： Understanding developing utilization in medicine functions medicine and food homology

Research progress of ginger in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1835-1851页

作者： Guo-Qing Chen Yi Nan Shi-Cong Huang Na Ning Yu-Hua Du Dou-Dou Lu Ya-Ting Yang Fan-Di Meng Ling Yuan College of Pharmacy Ningxia Medical CollegeYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Ethnomedicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Cancer seriously endangers human *** cancer is the most common and major malignant tumor,and its morbidity and mortality are gradually *** there are effective treatments such as radio-therapy and chemotherapy for gastrointestinal tumors,they are often accom-panied by serious side *** to the traditional Chinese medicine and food homology theory,many materials are both food and ***,food is just as capable of preventing and treating diseases as *** and food homologous herbs not only have excellent pharmacological effects and activities but also have few side *** a typical medicinal herb with both medicinal and edible uses,some components of ginger have been shown to have good efficacy and safety against cancer.A mass of evidence has also shown that ginger has anti-tumor effects on digestive tract cancers(such as gastric cancer,colorectal cancer,liver cancer,laryngeal cancer,and pancreatic cancer)through a variety of *** aim of this study is to investigate the mechanisms of action of the main components of ginger and their potential clinical applications in treating gastrointestinal tumors.

关键词： Ginger medicine and food homology Gastrointestinal cancer Molecular mechanism Tumor

Chemical constituents and pharmacological activities of medicinal plants from Rosa genus

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Chinese Herbal medicines 2022年第2期14卷 187-209页

作者： Yansheng Wang Yanmin Zhao Xinnan Liu Jingyang Li Jingze Zhang Dailin Liu Tianjin University of Traditional Chinese medicine Tianjin 301617China Tianjin Modern Innovation Chinese medicine Technology Co. Ltd.Tianjin 300380China Logistics College of Chinese People’s Armed Police Forces Tianjin 300309China

The genus Rosa(Rosaceae family)includes about 200 species spread in the world,and this genus shows unique advantages in medicine and *** date,several scholars concentrated on compounds belonging to flavonoids,triterpenes,tannins,polysaccharide,phenolic acids,fatty acids,organic acids,carotenoids,and *** effects such as antineoplastic and anti-cancer properties,antiinflammatory,antioxidant,liver protection,regulate blood sugar,antimicrobial activity,antiviral activity,as well as nervous system protection and cardiovascular protection were wildly *** article reviews the chemical constituents,pharmacological effects,applications and safety evaluations of Rosa plants,which provides a reference for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of the genus Rosa.

关键词： medicine and food homology pharmacological effect phytochemistry Rosa safety

Perilla frutescens:A traditional medicine and food homologous plant

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Chinese Herbal medicines 2023年第3期15卷 369-375页

作者： Xinling Wu Shuting Dong Hongyu Chen Miaoxian Guo Zhiying Sun Hongmei Luo College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Key Lab of Chinese medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering Research Center of Chinese medicine Resource Ministry of EducationBeijing 100193China

Perilla frutescens,an annual herb of the Labiatae family,has been cultivated in China for more than 2000 *** is the one of the first medicinal and edible plant published by the Ministry of *** leaves,stems and seeds can be used as medicine and edible *** of the abundant nutrients and bioactive components in this plant,*** has been studied extensively in medicine,food,health care and chemical fields with great prospects for *** paper reviews the cultivation history,chemical compositions and pharmacological activities of ***,which provides a reference for the development and utilization of *** resources.

关键词： bioactive compounds medicine and food homology Perilla frutescens(L.)Britt pharmacological activities

Ethnopharmacology,phytochemistry,pharmacology and product application of Platycodon grandiflorum:A review

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Chinese Herbal medicines 2024年第3期16卷 327-343页

作者： Lanying Zhang Xinrui Wang Jingze Zhang Dailin Liu Gang Bai Tianjin University of Traditional Chinese medicine Tianjin 301617China Nankai University Tianjin 300353China Tianjin Modern Innovation Chinese medicine Technology Co. Ltd.Tianjin 300380China

Platycodonis Radix(Jiegeng in Chinese)is a well-known traditional Chinese medicine used for both medicinal and culinary *** historical use as an antitussive and expectorant has been extensively ***,to date,have identified 219 chemical constituents in Platycodon grandiflorum(Jacq.)***,encompassing 89 saponins,11 flavonoids,21 polysaccharides,14 phenolic acids,six polyacetylenes,five sterols,34 fatty acids,17 amino acids,and 22 trace *** exhibits diverse pharmacological effects,including antitussive and anti-phlegm properties,anti-cancer activity,anti-inflammatory effects,immune regulation,antioxidant properties,anti-obesity,and antidiabetic ***,Jiegeng shows potential in protecting the heart and *** its medicinal benefits,Jiegeng is highly esteemed in culinary applications,and its global demand is on the *** utilization has expanded beyond medicine and food to encompass daily necessities,cosmetics,agricultural supplies,and other ***,there are 18272 patents related to *** comprehensive review summarizes the latest research published over the past 20 years,providing a robust foundation for further exploration of the medicinal and health benefits of ***.

关键词： application chemical constituents Jiegeng medicine and food homology Platycodon grandiflorum(Jacq.)A.DC

Ethnopharmacology, phytochemistry and pharmacology of Benincasae Exocarpium: A review

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Chinese Herbal medicines 2023年第1期15卷 15-26页

作者： Meng Zhang Jialong Lei Yansheng Wang Jingze Zhang Dailin Liu Tianjin University of Traditional Chinese medicine Tianjin 301617China Tianjin Modern Innovation Chinese medicine Technology Co. Ltd.Tianjin 300380China

Benincasae Exocarpium(BE,Dongguapi in Chinese),as the dried outer pericarp of Benincasa hispida(wax gourd)in Cucurbitaceae family,is one of traditional Chinese medicines with the same origin as medicine and *** to now,43 compounds were isolated from BE,including flavonoids,alkaloids,tannins,phenolic acids,soluble fiber and *** pharmacological studies and clinical practice showed that BE has diuretic,hypolipidemic effects,hypoglycemic,antioxidant,antibacterial,and other *** folk uses,functional factors,pharmacological activities,patents and clinical applications of BE were reviewed in this *** addition,the paper also discussed the current problems for the further *** information summarized in this paper provides valuable clues for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of BE.

关键词： Benincasa hispida(Thunb.)Cogn Benincasae Exocarpium medicine and food homology modern pharmacology functional constituents

Mendelian Randomization Study of Causal Relationship between Inflammatory Factors and Vascular Dementia and Chinese Herbal medicines Screening for Prevention and Treatment

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Journal of Biosciences and medicines 2024年第10期12卷 270-284页

作者： Jinzhi Zhang Wei Chen Guifeng Zhuo Chun Yao Mingyang Su Bingmao Yuan Xiaomin Zhu Zizhen Zhou Fengyi Lei Yulan Fu Lin Wu Department of Neurology The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning China The First Clinical College of medicine Guangxi University of Chinese Medicine Nanning China Graduate School Guangxi University of Chinese Medicine Nanning China

Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their c

关键词： Inflammatory Factors Vascular Dementia Mendelian Randomization Study Causal Association Chinese medicine Prediction medicine and food homology

The Protective Effect of Jiujiuguiyi, a medicine and food Homologous Formula, on Acute Alcohol Poisoning Mice

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TMR Modern Herbal medicine 2019年第3期2卷 121-130页

作者： Yang-Fan Zhou Tian-Ze Zhang Si-Qi Deng Meng Zhang Yu-Jiao Zhan Yi-Fang Li Rong-Rong He Guangdong Province Research and Development Center for Chinese medicine in Disease Susceptibility College of PharmacyJinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) College of PharmacyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China

Background: Nowadays, acute alcoholic intoxication has become the third public problem in China, and the anti-inebriation products mainly aimed at increasing the activity of enzyme involved in the alcohol metabolism, which is a single mechanism that can accelerate alcohol metabolism. Thus, a new formula, Jiujiuguiyi (JJGY) which could protect liver, relieve the abnormal excitability of the center and improve muscle retardation at the same time is designed by us. Methods: The model of acute alcoholic intoxication was established by intragastric administration with 0.12 ml/10g 50% alcohol in mice. JJGY was orally administrated (gavage) once a day for 20 consecutive days before the establishment of acute alcoholic model. Mice were randomly divided into 8 groups with 8 each: blank control group (CON), model group (M), Haiwangjinzun positive control group (HWJZ), experimental groups (AL, AH, BL, BH, AB). Giant, crawling time on the rota-rod, the activities of aspartate amino trans- ferase (AST), alanine amino transferase (ALT) and superoxide dismutase (SOD) in both liver and serum, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), glutathione peroxidase (GSH-PX) in liver as well as the HE staining of liver slices, the formation of malondialdehyde (MDA) in serum were determined after acute alcoholic intoxication. Results: Compared with model group, JJGY significantly decreased the AST and ALT activity in liver and serum and MDA activity in serum. Meanwhile, it enhanced the ADH and ALDH level in liver as well as the hepatic and serous SOD activity, indicating more efficient metabolism of alcohol and less hepatic injury. HE staining results also proved that JJGY could reduce alcoholic liver cell injury, and the effect was more obvious in the group medicated before alcohol administration. Moreover, JJGY significantly prolonged the crawling time on the rota-rod and improved the gait of mice and the effect was proved to be better than the widely used health produc

关键词： Jiujiuguiyi (JJGY) acute alcoholic intoxication of mice medicine and food homology ethology test