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Embryo-Engineered Nonhuman Primate Models:Progress and Gap to Translational medicine

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Research 2021年第1期2021卷 1627-1639页

作者： Mei Huang Jiao Yang Peng Li Yongchang Chen Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China State Key Laboratory of Primate Biomedical Research Kunming 650500China

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions.As close relatives of humans,nonhuman primates(NHPs)play an increasingly indispensable role in advancing translational medicine research.In this review,we summarized the progress of NHP models generated by embryo engineering,analyzed their unique advantages in mimicking clinical patients,and discussed the remaining gap between basic research of NHP models to translational medicine.

关键词： diseases medicine translational

Internet survey on the provision of complementary and alternative medicine in Japanese private clinics: a cross-sectional study

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Journal of Integrative medicine 2019年第1期17卷 8-13页

作者： Yoshiharu Motoo Keiko Yukawa Kazuho Hisamura Kiichiro Tsutani Ichiro Arai Department of Medical Oncology Kanazawa Medical University Department of Health Policy and Technology Assessment National Institute of Public Health Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Pharmaceutical Sciences Nihon Pharmaceutical University

Objective: Although the use of complementary and alternative medicine(CAM) by the general population has been surveyed previously, the provision of CAM by Japanese physicians in private clinics has not been studied. Universal health insurance system was established in Japan in 1961, and most CAMs are not on the drug tariff. We aimed to clarify the current status of CAM provided by physicians at private clinics in Japan.Methods: We conducted an internet survey on 400 directors/physicians of private clinics nationwide on the provision of CAM from February 6 to February 10, 2017. Survey items included attributes of subjects,presence/absence of sections or facilities for provision of CAM, proportions of health insurance coverage for medical practices, and source of information. Private clinic was defined as a clinic run by one physician, with less than 20 beds.Results: Commonly provided CAMs were Kampo(traditional Japanese herbal) medicines(34.8%) and supplements/health foods(19.3%). CAMs on the drug tariff were provided in 46.5% of cases at the clinics, but only 16.5% of cases were provided CAMs which were not on the drug tariff, at different neighboring facilities. Among different specialties, Kampo medicines were prescribed at obstetrics/gynecology(54.0%),orthopedics(44.4%), and dermatology(43.0%). Clinics not providing any CAM accounted for 53.5%.With regard to health insurance coverage, 96.8% of the clinics provided only or mainly health services on the universal national health insurance tariff(29.8% and 67.0%, respectively).Conclusion: Kampo medicines represent the most commonly used CAM in private clinics in Japan, and universal national health insurance coverage is considered to be the reason for the high rate of their use.

关键词： Japan Complementary and alternative medicine Private clinic Internet survey Kampo

Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia:a randomized,open-label,active-controlled trial

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Journal of Integrative medicine 2017年第3期15卷 201-208页

作者： Ghazaleh Heydarirad Hossein Rezaeizadeh Rasool Choopani Seyed Hamdollah Mosavat Ahmad Ameri Department of Traditional medicine School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran 15167-45811 Iran Department of Traditional medicine School of Traditional Medicine Tehran University of Medical Science Tehran 16687-53961 Iran Research Center for Traditional medicine and History of medicine Shiraz University of Medical SciencesShiraz 71356-44144 Iran Essence of Parsiyan Wisdom Institute Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences Shiraz 71356-44144 Iran Department of Radiation Oncology Imam Hossein Hospital Shahid Beheshti University of Medical SciencesTehran 19946-15611 Iran

BACKGROUND： Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers （HNC）. However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE： Synthesizing the traditional use ofAIcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life （QOL） of HNC patients with radiation-induced xerostomia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect ofA. digitata and M. sy/vestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix （artificial saliva）. Patients were enrolled from the Imam Hossein Hospital＇s oncology clinic in Shahid Beheshti University of Medica Sciences. Tehran, Iran. MAIN OUTCOME MEASURES： Primary outcome measures in this trial were changes in patients＇ QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module （EORTC QLQ-H＆N 35）. RESULTS： Between-group analysis showed that the intervention group patients obtained significantly lower （better） total EORTC QLQ-H＆N 35 scores as compared to the control group at the end of the intervention period （P = 0.007）. Mean scores of dry mouth of EORTC QLQ-H＆N 35 was also significantly lower （better） in the intervention group as compared to the control group （P = 0.017）.

关键词： xerostomia medicine Persian traditional hollyhocks common mallow cancer

The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran

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Journal of Integrative medicine 2019年第4期17卷 296-301页

作者： Mohammad Hossein Ayati Ata Pourabbasi Nazli Namazi Arman Zargaran Zahra Kheiry Amir Hooman Kazemi Bagher Larijani Department of Traditional medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Department of History of medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran ***Iran Diabetes Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran *** Iran Department of Traditional Pharmacy School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Idea Development and Innovation Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran *** Iran

Background: The use of traditional and complementary medicine (T&CM) is increasing in both developed and developing countries. The school of Persian medicine (PM) in Iran is a comprehensive medical school that is rich in history and has its own special principles, elements, philosophy, and diagnostic and treatment options. Many complementary therapy modalities are also popular and in demand among patients and physicians. The aim of this paper is to provide logic for the policymakers in Iranian medical education to make changes in medical education curricula, particularly on integrating T&CM. Methods: We reviewed the global experience in teaching T&CM to medical students, and highlighting the strengths of PM, described why it is necessary to integrate T&CM into general medicine curricula in Iran. Results: PM is a traditional system of medicine that dates back about 7000 years. Although there are few studies about the safety and effectiveness of PM, research into it has recently been accelerated. There is a suitable opportunity for integrating T&CM with conventional medicine. Physicians should be familiar with T&CM to avoid any contraindications, interactions, and unwanted effects. Conclusion: Traditional medicine is part of Iran's heritage and. thus, needs special attention. Familiarization of physicians with T&CM can help them choose the best treatment options for their patients. To integrate T&CM into the medical education curricula of Iran, a two-credit course has been proposed for implementation across the country.

关键词： Integrative medicine Traditional medicine Complementary medicine Medical education curriculum

EVALUATION OF RADIONUCLIDE BONE IMAGING FOR SKELETAL DISEASE

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Medical Bulletin of Shanghai Jiaotong University 1993年第2期16卷 37-39页

作者：林奋袁济民 Department of Orthopaedics Renji HospitalSSMU Department of Nuclear medicine Renji HospitalSSMU

Whole body bone scan imaging of 99mTc-MDP was performed in 80 casesfrom Sept 1991 to Feb 1992. Among them 20 patients showed negtive bone imaging and56 patients showed positive bone imaging. There were false-positive bone imaging in 4 pa-tients. Bone scan imaging has been regarded as a useful method in the early diagnosis ofshelatal disease, especially in old patients with bone metastasis. But the final confirmationof malignancy should be still cautious.

关键词： radionuclide scan imaging nuclear medicine skelatal disease

medicine is more than just knowledge or skill

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Chinese Medical Journal 2012年第7期125卷 1203-1205页

作者： LANG Jing-he Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing 100730China

To say that medicine is not knowledge or skill is apparently a contradiction. But to say that medicineis merely knowledge and skill is also off the mark. The famous remark by the American physician Edward Trudeau, to cure sometimes, to relieve often, to comfort always, is the essence of medicine and the embodiment of medical humanities.

关键词： medicine knowledge skill humanities

The present state of complementary medicine regulation in Saudi Arabia

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Journal of Integrative medicine 2019年第3期17卷 147-149页

作者： Tamer Aboushanab Mohamed Khalil Yaser Al Ahmari National Center for Complementary and Alternative medicine Ministry of Health

The prevalence of use of traditional and complementary medicine in the Saudi Arabia population has reached 75%. The most used therapies are religious healing, herbal medicine and cupping therapy. The National Center for Complementary and Alternative medicine is the Saudi national reference for all activities regarding complementary medicine. This article briefly highlights the current state of complementary medicine regulation in Saudi Arabia.

关键词： Complementary medicine Integrative medicine Cupping Acupuncture Saudi Arabia

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Meet the Expert

Asian Journal of Andrology 2024年第2期26卷 F0002-F0002页

Jorge Hallak,M.D.,Ph.D.Jorge Hallak graduated in medicine at the University of Sao Paulo Medical School in 1989(FMUSP).He has been a Full Professor in medicine at the University of Sao Paulo Medical School-FMUSP-Dept.of Pathology since 2018.He obtained Doctorate in medicine-Division of Urology(1999,FMUSP)and PhD degree at The Cleveland Clinic Foundation(1998,CCF-Ohio,USA).

关键词： medicine Medical Expert

Integrative medicine on Optimizing Clopidogrel and Aspirin Therapy

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Chinese Journal of Integrative medicine 2019年第5期25卷 395-400页

作者： CHEN Hui Department of Internal medicine Fujian Provincial Cardiovascular Disease Institutethe Shengli Clinical Medical College of Fujian Medical UniversityFuzhou(350001)China

This article reviews the available published data on optimizing clopidogrel and aspirin therapy using translational and integrative medicine. Translational and evidence-based medical studies show that the CYP2 C19 gene mutation(CYP2 C19*2 and CYP2 C19*3) could affect > 50% of the Chinese population, and that this mutation is closely associated with clopidogrel resistance and an increased risk of major adverse cardiovascular events, particularly stent thrombosis in patients following percutaneous coronary intervention(PCI). Adjusted-dose warfarin and aspirin reduce stroke in patients with atrial fibrillation(AF), and warfarin is substantially more efficacious than aspirin. However, a poor compliance is a big problem in warfarin use especially in China. The genetic variants of vitamin K expoxide reductase might account for the universally lower warfarin dosage used in Chinese population. The available evidence indicates that the integrating mainstream treatments(e.g., clopidogrel, CYP2 C19 genotyping) and non-mainstream medicines [e.g., Chinese medicines,Naoxintong Capsule(脑心通胶囊, NXT)] to treat CYP2 C19 gene mutation patients following PCI can be effective.Aspirin combined NXT and the adjusted-dose warfarin was equally effective in elderly patients with non-valvular AF in prevention of ischemic stroke.

关键词： integrative medicine clopidogrel aspirin optimizing therapy Chinese medicine