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Analysis of fibronectin, fibronectin receptor and interleukin 1 in patients with cirrhosis treated by Yanggan Jieyu decoction

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World Journal of Gastroenterology 1997年第3期3卷 49-51页

作者： WU Hong, GAO Jie Sheng, FAN Jian Zhen, Huang Jing and DENG Jan Wei

AIM To investigate the adjusting effects of the Yanggan Jieyu (YGJY, nourishing the liver and alleviate mental depression) decoction on the plasma concentration of fibronectin (FN), fibronectin receptor (FNR), tumor necrosis factor alpha (TNF α) and the activity of interleukin 1 (IL 1) in patients with cirrhosis. METHODS Thirty four cases of cirrhosis (in decompensation) were divided into YGJY decotion treated group and control group treated by routine method. FN, FNR and TNF α were measured with ELESA and expressed as mg/L (FN, FNR) and ng/L (TNF α), and IL 1 was measured by mice thymocyte proliferation using β scintillation counter and expressed as cpm. RESULTS In YGJY decoction treated group, before treatment, FN was 247 9±97 2, FNR 5 6±2 7, TNF α 83 9±7 1 and IL 1 was 2760 8±813 6, and after treatment. FN was 298 3±93 2 ( P 0 01), FNR 4 3±2 3 ( P 0 05, TNF α 93 6±12 0 ( P 0 05) and IL 1 was 1922 3±847 0 ( P 0 05). The FN and TNF α plasma level after treatment increased remarkably, while FNR and IL 1 decreased obviously. In the control group before treatment, FN was 248 8±101 9, FNR 5 5±1 9, TNF α 126 1±48 1 and IL 1 was 2540 6±603 2, and after treatment was 241 6±77 1 ( P >0 05), FNR 5 4±1 2 ( P >0 05), TNF α 100 6±15 5 ( P >0 05) and IL 1 was 2360 6±860 0 ( P >0 05), the plasma levels of FN, TNF α, FNR and IL 1 did not change signifiantly. CONCLUSION YGJY decoction could prevent the process of the hepatic fibrosis by readjusting the plasma levels of FN, FNR, TNF α and IL 1 mediating acivities in cirrhosis, which is of clinical significance.

关键词： liver cirrhosis Yan Gan Jie Yu decoction fibronectin receptors, fibronectin tumor necrosis factor interleukin 1 medicine, Chinese traditional

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The Security of Platelet-rich Plasma in Sports-relatedInjuries

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Journal of Health Science 2014年第8期2卷 363-369页

作者： Leticia Rivero Gonzalez Gabriel Lupon Escobar LluisTil Perez Sara Estevez Sarmiento Fuerteventura Hospital Clinica Roca Sports Medical Unit Gran Canaria Hospital Universitario Insular de Gran Canaria LasPalmas de Gran Canaria Las Palmas 35016 Spain Sports medicine Consorci Sanitari de Terrassa (CST) in Olympic Training Center (CAR) Sant Cugat del Vall~s 08173 Spain Sports medicine FC Barcelona Barcelona 08028 Spain Hospital Universitario Insular de Gran Canaria Las Palmas de Gran Canaria Las Palmas 35016 Spain

Platelet-rich plasma （PRP） therapy in orthopedics and sports medicine has seen an expansion in use since 2003. Theobjective of this study is to not only review evidence of clinical effectiveness but also to evaluate its security and detect any disparitybetween its use and its popularity. A prospective, descriptive study, which included 104 athletes were performed. Minor adverse effectswere recorded and these were self-limited. Although there is a lack of more detailed studies which compare other factors, PRP therapyhas been shown to have positive results in relation to certain lesions.

关键词： Sports medicine, growth factors, muscles, tendons, ligaments, platelet-rich plasma.

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