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Fentanyl and xylazine crisis:Crafting coherent strategies for opioid overdose prevention

World Journal of Psychiatry 2024年第6期14卷 760-766页

作者： Lakshit Jain Jasleen Kaur Shahana Ayub Danya Ansari Rizwan Ahmed Abdul Qadir Dada Saeed Ahmed Department of Psychiatry University of ConnecticutFarmingtonCT 06032United States Addiction Services Division Connecticut Valley HospitalMiddletownCT 06457United States Department of Psychiatry Institute of LivingHartfordCT 06102United States Department of Medicine Islamabad Medical and Dental CollegeIslamabad 44000Pakistan Department of Medicine Liaquat College of Medicine and DentistryKarachi 75290Pakistan Department of Medicine Trinity School of MedicineRoswellGA 30075United States Addiction Services and Dual Diagnosis Unit Saint Francis Hospital and Medical CenterHartfordCT 06105United States

The United States is in the throes of a severe opioid overdose epidemic,primarily fueled by the pervasive use of fentanyl and the emerging threat of xylazine,a veterinary sedative often mixed with fentanyl.The high potency and long duration of fentanyl is compounded by the added risks from xylazine,heightening the lethal danger faced by opioid users.Measures such as enhanced surveillance,public awareness campaigns,and the distribution of fentanylxylazine test kits,and naloxone have been undertaken to mitigate this crisis.Fentanyl-related overdose deaths persist despite these efforts,partly due to inconsistent policies across states and resistance towards adopting harm reduction strategies.A multifaceted approach is imperative in effectively combating the opioid overdose epidemic.This approach should include expansion of treatment access,broadening the availability of medications for opioid use disorder,implementation of harm reduction strategies,and enaction of legislative reforms and diminishing stigma associated with opioid use disorder.

关键词： Fentanyl Xylazine opioid overdose Epidemic opioid use disorder Buprenorphine medications for opioid use disorder

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