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medical devices 个人睡眠教练

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科技创业 2010年第1期 23-23页

如果你曾经想知道在一个辗转反侧的晚上,你究竟睡着了多长时间,一款新的家用睡眠质量监测设备可以为你提供答案。使用者在睡觉的时候需要戴一个头箍,头箍上装有负责监控大脑内电流活动情况的传感器。医生使用类似从脑电图里获取的数据来

关键词：教练 medical devices

Plain metallic biomaterials:opportunities and challenges

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Regenerative Biomaterials 2023年第1期10卷 140-147页

作者： Jiazhen Zhang Bao Zhai Jintao Gao Zheng Li Yufeng Zheng Minglong Ma Yongjun Li Kui Zhang Yajuan Guo Xinli Shi Bin Liu Guobiao Gao Lei Sun Center for medical Device Evaluation National Medical Product AdministrationBeijing 100081China Guangdong-Hong Kong-Macao Greater Bay Area Center for Medical Device Evaluation and Inspection of NMPAShenzhen 518045China School of Materials Science and Engineering Peking UniversityBeijing 100871China State Key Laboratory of Nonferrous Metals and Process GRINM Group Corporation Limited(General Research Institute for Nonferrous Metals)Beijing 100088China

The‘plainification of materials’has been conceptualized to promote the sustainable development of *** perspective,for the first time in the field of biomaterials,proposes and defines‘plain metallic biomaterials(PMBs)’with demonstrated research and application case studies of pure titanium with high strength and toughness,and biodegradable,fine-grained and high-purity ***,after discussing the features,benefits and opportunities of PMBs,the challenges are analyzed from both technical and regulatory *** perspectives on PMB-based medical devices are also provided for the benefit of future research,development and commercialization.

关键词： plainification metallic biomaterials regulatory science medical devices pure titanium high-purity magnesium

Powder metallurgy with space holder for porous titanium implants:A review

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Journal of Materials Science & Technology 2021年第17期76卷 129-149页

作者： Alejandra Rodriguez-Contreras Miquel Punset JoséA.Calero Francisco Javier Gil Elisa Ruperez JoséMaría Manero Biomaterials Biomechanics and Tissue Engineering Group(BBT)Department of Materials Science and EngineeringUniversitat Politecnica de Catalunya(UPC)Av.Edurad Maristany 1608019BarcelonaSpain Barcelona Research Centre in Multiscale Science and Engineering Technical University of Catalonia(UPC)Av.Eduard Maristany 10-1408019BarcelonaSpain UPC Innovation and Technology Center(CIT-UPC).Technical University of Catalonia(UPC) C.Jordi Girona 3-108034Barcelona.Spain AMES GROUP SA.Carretera Nacional 340 Pol.Ind."Les Fallulles"08620Sant Vicenc dels HortsBarcelonaSpain Bioengineering Institute for Technology Universitat Intemacional de Catalunyac/Josep Trueta s/n08195BarcelonaSpain

One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical *** stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis ***,it can be inhibited by adapting the stiffness of the implant *** the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this *** powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and *** most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography ***,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are ***,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented.

关键词： Powder metallurgy Space holder method Porous titanium structures medical devices Stress shielding effect Porous materials permeability Interconnected porosity Porous bone substitute materials Open-cell titanium foams Sintering-dissolution technique

Biofunctionalized all-polymer photonic lab on a chip with integrated solid-state light emitter

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Light(Science & Applications) 2015年第1期4卷 430-437页

作者： Andreu Llobera Joan Juvert Alfredo Gonzalez-Fernandez Bergoi Ibarlucea Ester Carregal-Romero Stephanus Buttgenbach Cesar Fernandez-Sanchez Instituto de Microelectronica de Barcelona IMB-CNM(CSIC) Campus UAB08193 BellaterraSpain Institut fur Mikrotechnik Technische Universitat BraunschweigBraunschweig 38106Germany

A photonic lab on a chip(PhLOC),comprising a solid-state light emitter(SSLE)aligned with a biofunctionalized optofluidic multiple internal reflection(MIR)system,is *** SSLE is obtained by filling a microfluidic structure with a phenyltrimethoxysilane(PhTMOS)aqueous sol solution containing a fluorophore organic *** curing,the resulting xerogel solid structure retains the emitting properties of the fluorophore,which is evenly distributed in the xerogel *** studies demonstrate that after a total dose(at λ5365 nm)greater than 24 J cm^(-2),the xerogel emission decay is only 4.1%.To re-direct the emitted light,the SSLE includes two sets of air mirrors that surround the *** mapping of the SSLE demonstrates that alignment variations of 150 mm(between the SSLE and the external pumping light source)provide fluctuations in emitted light smaller than 5%.After this verification,the SSLE is monolithically implemented with a MIR,forming the *** performance is assessed by measuring quinolone yellow,obtaining a limit of detection(LOD)of(0.6060.01)***,the MIR is selectively biofunctionalized with horseradish peroxidase(HRP)for the detection of hydrogen peroxide(H_(2)O_(2))target analyte,obtaining a LOD of(0.760.1)μM for H_(2)O_(2),confirming,for the first time,that solid-state xerogel-based emitters can be massively implemented in biofunctionalized PhLOCs.

关键词： medical devices photonic lab on a chip polymer technology solid-state light emitters sol–gel

Unified Computational Modelling for Healthcare Device Security Assessment

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Computer Systems Science & Engineering 2021年第4期37卷 1-18页

作者： Shakeel Ahmed Abdulaziz Alhumam Department of Computer Science College of Computer Sciences and Information Technology King Faisal UniversityAl-Ahsa31982Kingdom of Saudi Arabia

This article evaluates the security techniques that are used to maintainthe healthcare devices, and proposes a mathematical model to list these in theorder of priority and preference. To accomplish the stated objective, the articleuses the Fuzzy Analytic Network Process (ANP) integrated with Technical forOrder Preference by Similarities to Ideal Solution (TOPSIS) to find the suitablealternatives of the security techniques for securing the healthcare devices fromtrespassing. The methodology is enlisted to rank the alternatives/ techniquesbased on their weights’ satisfaction degree. Thereafter, the ranks of the alternatives determine the order of priority for the techniques used in healthcare *** findings of our analysis cite that Machine Learning (ML) based healthcaredevices obtained the highest priority among all the other security *** the developers, manufacturers and researchers should focus on the MLtechniques for securing the healthcare devices. The results drawn through theaid of the suggested mathematical model would be a corroborative referencefor the developers and the manufacturers in assessing the security techniques ofthe healthcare devices.

关键词： medical devices fuzzy-ANP.TOPSIS security techniques machine learning

Candida albicans aspects of binary titanium alloys for biomedical applications

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Regenerative Biomaterials 2020年第2期7卷 213-220页

作者： Shuyang Chen James K.H.Tsoi Peter C.S.Tsang Yeong-Joon Park Ho-Jun Song Jukka P.Matinlinna Dental Materials Science Division of Applied Oral Sciences&Community Dental CareFaculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China Department of Prosthodontics Tianjin Stomatological HospitalNo.75Dagu RoadHeping DistrictTianjin 300041People’s Republic of China Division of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China and 4 Department of Dental Materials and MRC for Hard-tissue Biointerface School of DentistryChonnam National UniversityGwangju 61186Republic of Korea

Titanium and its alloys are widely used in biomedical devices,***,due to its biocompati-bility and osseointegration *** fact,fungal(Candida spp.)infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the ***,this study evaluated the surface morphology,surface chemical composition and Candida albicans adhesion on specimens of 16 binary Tialloys(-5 wt%of any one of the alloy elements:Ag,AI,Au,Co,Cr,Cu,Fe,In,Mn,Mo,Nb,Pd,Pt,Sn,V and Zr)compared with cp-Ti,targeting to seek for the binary Ti-alloys which has the lowest *** *** albicans cultures were grown on the specimens for 48 h,and colony forming units(CFUs)and real-time polymerase chain reaction(RT-PCR)were used to evaluate the biofilm formation *** electron mi-croscopy and confocal laser scanning microscopy confirmed the formation of *** biofilm on all specimens'surfaces,such that CFU results showed Ti-Mo,Ti-Zr,Ti-AI and Ti-V have less *** formed on the surfaces than ***-PCR showed Ti-Zr and Ti-Cu have significantly higher *** DNA concentrations than Ti-AI and Ti-V(Pmedical devices,but Ti-Cu should be used in caution.

关键词： titanium binary titanium alloy C.albicans,fungal infection medical devices

Advances in medical Applications of Additive Manufacturing

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Engineering 2020年第11期6卷 1222-1231页

作者： Chunxu Li Dario Pisignano Yu Zhao Jiajia Xue Department of Orthopaedics Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing J 00730China National Enterprise for Nanoscience and Nanotechnology Nanoscience InstituteNational Research CouncilPisa 1-56127Italy Department of Physics University of PisaPisa 1-56127Italy Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029China

In the past few decades,additive manufacturing(AM)has been developed and applied as a cost-effective and versatile technique for the fabrication of geometrically complex objects in the medical *** this review,we discuss current advances of AM in medical applications for the generation of pharmaceuticals,medical implants,and medical *** and transdermal drugs can be fabricated by a variety of AM *** types of hard and soft clinical implants have also been realized by AM,with the goal of producing tissue-engineered *** addition,medical devices used for diagnostics and treatment of various pathological conditions have been *** growing body of research on AM reveals its great potential in medical *** goal of this review is to highlight the usefulness and elucidate the current limitations of AM applications in the medical field.

关键词： Additive manufacturing medical applications Pharmaceutics medical implants medical devices

Internet of medical Things (IoMT): Overview, Taxonomies, and Classifications

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Journal of Computer and Communications 2022年第8期10卷 64-89页

作者： Ahmed E. Khaled Department of Computer Science Northeastern Illinois University Chicago IL USA

Recent research efforts have created rapid advances in the field of the Internet of Things (IoT) in terms of communication protocols, sensing technologies, computing capabilities, next-generation wireless technologies, big data and AI techniques, and on-device, edge, cloud processing. These advances created a paradigm shift and generated a wide range of potential opportunities for a new major field known as the Internet of medical Things (IoMT), as well as subfields like mobile Health (mHeatlh) and digital or electronic Health (eHealth). This paper provides an overview of the Internet of medical Things and presents a classification to define the primary users and their roles and involvement in smart healthcare systems. The paper then presents taxonomy on the deployment scales of different healthcare environments, from personal healthcare to widescale connected healthcare systems. The overview also discusses the n-tier architecture of IoMT, then presents a set of taxonomies and classifications on the different medical devices used in healthcare systems as well as non-medical devices used to provide context-aware information about the surrounding environment. The paper then concludes the overview by presenting the different healthcare-related applications and services, a comparison between traditional and smart healthcare systems, and the different obstacles and challenges in the field of IoMT to guide the development of new services and devices. Many survey papers in the literature focused on similar points;however, up to our knowledge, this is the first paper to present taxonomies and classifications for these IoMT essential topics. The presented taxonomies and classifications provide the manufacturers of medical devices and the developers of healthcare services a deeper understanding of the healthcare systems’ landscape to address different requirements and demands.

关键词： IoMT medical devices Applications Services mHealth eHealth Connected Healthcare

Expediting the transition from replacement medicine to tissue engineering

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Regenerative Biomaterials 2016年第2期3卷 111-113页

作者： Arthur J.Coury Department of Chemical Engineering Northeastern UniversityBostonMAUSA

In this article,an expansive interpretation of“Tissue Engineering”is proposed which is in congruence with classical and recent published definitions.I further simplify the definition of tissue engineering as:“Exerting systematic control of the body’s cells,matrices and fluids.”As a consequence,many medical therapies not commonly considered tissue engineering are placed in this category because of their effect on the body’s *** the progress of tissue engineering strategies is inexorable and generally positive,it has been subject to setbacks as have many important medical *** practice is currently undergoing a transition on several fronts(academics,start-up companies,going concerns)from the era of“replacement medicine”where body parts and functions are replaced by mechanical,electrical or chemical therapies to the era of tissue engineering where health is restored by regeneration generation or limitation of the body’s tissues and functions by exploiting our expanding knowledge of the body’s biological processes to produce natural,healthy outcomes.

关键词： tissue engineering medical devices combination products regenerative medicine