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Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

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Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra Tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun Diao Yanping Zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina Guangzhou Hongai Cultural Development Inc.GuangzhouGuangdong ProvinceChina Yinguo Health Management Team GuangzhouGuangdong ProvinceChina College of Biophotonics South China Normal UniversityGuangzhouGuangdong ProvinceChina

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual *** sounds the singing bowls produce have been shown to enhance relaxation and reduce ***,the underlying mechanism remains *** this study,we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like *** then supplied treatment with singing bowls in a bottomless cage placed on the top of a *** found that unlike in humans,the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice,while individual vibration components ***,the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice,decreased the level ofγ-aminobutyric acid A(GABA)receptorα1 subtype,reduced the level of CaMKII in the prefrontal cortex,and increased the number of GABAergic *** the same time,electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep *** from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

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Modulation of Nicotine-Associated Behaviour in Rats Byμ-Opioid Signals from the medial prefrontal cortex to the Nucleus Accumbens Shell

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Neuroscience Bulletin 2024年第12期40卷 1826-1842页

作者： Feng Zhu Hirosato Kanda Hiroyuki Neyama Yuping Wu Shigeki Kato Di Hu Shaoqi Duan Koichi Noguchi Yasuyoshi Watanabe Kazuto Kobayashi Yi Dai Yilong Cui Department of Anatomy and Neuroscience Hyogo Medical UniversityNishinomiyaHyogo663-8501Japan Laboratory for Brain-Gut Homeostasis Hyogo Medical UniversityNishinomiyaHyogo663-8501Japan School of Pharmacy Hyogo Medical UniversityKobeHyogo650-8530Japan School of PharmacyHyogo Medical UniversityKobeHyogo650-8530Japan RIKEN Center for Biosystems Dynamics Research KobeHyogo650-0047Japan Department of Molecular Genetics Fukushima Medical University Institute of Biomedical SciencesFukushima960-1295Japan

Nicotine addiction is a concern *** mechanistic investigations are on nicotine substance dependence properties based on its pharmacological ***,no effective therapeutic treatment has been *** addiction is reinforced by environments or *** demonstrate the neurobiological basis of the behavioural aspect of nicotine *** utilized the conditioned place preference to establish nicotine-associated behavioural preferences(NABP)in ***-wide neuroimaging analysis revealed that the medial prefrontal cortex(mPFC)was activated and contributed to *** manipulation ofµ-opioid receptor positive(MOR+)neurons in the mPFC or the excitatory outflow to the nucleus accumbens shell(NAcShell)modulated the *** recording confirmed that the MOR+neurons directly regulate the mPFC-NAcShell circuit via GABAA ***,the MOR+neurons in the mPFC modulate the formation of behavioural aspects of nicotine addiction via direct excitatory innervation to the NAcShell,which may provide new insight for the development of effective therapeutic strategies.

关键词： Nicotine-associated behaviour μ-Opioid receptor medial prefrontal cortex Nucleus accumbens shell Small-animal neuroimaging

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Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the medial prefrontal cortex

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Neuroscience Bulletin 2020年第6期36卷 570-584页

作者： Bin Yu Bo Yuan Jian-Kun Dai Tian-lin Cheng Sheng-Nan Xia Ling-Jie He Yi-Ting Yuan Yue-Fang Zhang Hua-Tai Xu Fu-Qiang Xu Zhi-Feng Liang Zi-Long Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Molecular and Human Genetics Howard Hughes Medical InstituteBaylor College of MedicineHoustonTX 77030USA Wuhan Institute of Physics and Mathematics Chinese Academy of SciencesWuhan 430071China

Methyl-CpG binding protein 2(MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA *** of MECP2-containing genomic segments causes MECP2 duplication syndrome,a severe neurodevelopmental disorder characterized by intellectual disability,motor dysfunction,heightened anxiety,epilepsy,autistic phenotypes,and early *** of the abnormal phenotypes in adult mice with MECP2 duplication(MECP2-TG) by normalizing the MeCP2 levels across the whole brain has been ***,whether different brain areas or neural circuits contribute to different aspects of the behavioral deficits is still ***,we found that MECP2-TG mice showed a significant social recognition deficit,and were prone to display aversive-like behaviors,including heightened anxiety-like behaviors and a fear generalization *** addition,reduced locomotor activity was observed in MECP2-TG ***,appetitive behaviors and learning and memory were comparable in MECP2-TG and wild-type *** magnetic resonance imaging illustrated that the differences between MECP2-TG and wild-type mice were mainly concentrated in brain areas regulating emotion and social *** used the CRISPR-Cas9 method to restore normal MeCP2 levels in the medial prefrontal cortex(mPFC) and bed nuclei of the stria terminalis(BST) of adult MECP2-TG mice,and found that normalization of MeCP2 levels in the mPFC but not in the BST reversed the social recognition *** data indicate that the mPFC is responsible for the social recognition deficit in the transgenic mice,and provide new insight into potential therapies for MECP2 duplication syndrome.

关键词： MECP2 duplication medial prefrontal cortex Social recognition deficit CRISPR-Cas9

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Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats

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Animal Models and Experimental Medicine 2022年第3期5卷 274-280页

作者： Yu Zhang Xiuping Sun Changsong Dou Xianglei Li Ling Zhang Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina National Human Diseases Animal Model Resource Center BeijingChina Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases BeijingChina International Center for Technology and Innovation of animal model BeijingChina Changping National laboratory(CPNL) BeijingChina

Object:Early-life neglect has irreversible emotional effects on the central nervous *** this work,we aimed to elucidate distinct functional neural changes in me-dial prefrontal cortex(mPFC)of model ***:Maternal separation with early weaning was used as a rat model of early-life *** excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole-cell patch ***:Glutamatergic and GABAergic neurons of mPFC were distinguished by typi-cal electrophysiological *** excitation of mPFC glutamatergic neurons was significantly increased in male groups,while the excitation of mPFC GABAergic neurons was significant in both female and male groups,but mainly in terms of rest membrane potential and amplitude,***:Glutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-life neglect,which can contribute to distinct mechanisms for emotional and cognitive manifestations.

关键词： early-life neglect model GABAergic glutamatergic maternal separation with early weaning medial prefrontal cortex neuronal excitability

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Effects of Melatonin Levels on Neurotoxicity of the medial prefrontal cortex in a Rat Model of Parkinson＇s Disease

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Chinese Medical Journal 2017年第22期130卷 2726-2731页

作者： Yan Li Shu-Mei Wang Lei Guo Jian Zhu Ying Wang Lei Li Yan-Xin Zhao Department of Neurology Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China General Medical Teaching and Research Section Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China Department of Medical Imaging Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China Department of Medical Imaging Shandong Provincial Hospital Jinan Shandong 250014 China

Background： Damage of the medial prefrontal cortex （mPFC） results in similar characteristics to the cognitive deficiency seen with the progress of Parkinson＇s disease （PD）. Since the course of mPFC damage is still unclear, our study aimed to investigate the effects of melatonin （MT） on neurotoxicity in the mPFC of a rat model of PD. Methods： One hundred and fifty-four normal, male Wistar rats were randomly divided into the following five groups： normal ＋ normal saline （NS）, normal ＋ 6-hydroxydopamine （6-OHDA）, sham pinealectomy （PX）＋ 6-OHDA, PX ＋ 6-OHDA, and MT ＋ 6-OHDA. 6-OHDA was injected into the right substantia nigra pars compacta （SNc） and ventral tegmental area （VTA） of each group, except normal ＋ NS, 60 days after the PX. In the MT treatment group, MT was administered immediately after the intraperitoneal injection at 4 p.m. every day, for 14 days. Neuronal apoptosis in the mPFC was exalnined using the TUNEL method, while the expression oftyrosine hydroxylase （TH）, Bax, and Bcl-2 in this region was measured using immunohistochemistry. The concentration of malondialdehyde （MDA） in the mPFC was examined using the thioharbituric acid method. Results： Rats in the normal ＋ 6-OHDA and sham PX ＋ 6-OHDA groups were combined into one group （Group N ＋ 6-OHDA） since there was no significant discrepancy between the groups for all the detected parameters. Apoptosis of cells in the NS, MT ＋ 6-OHDA, N ＋ 6-OH DA, and PX ＋ 6-OHDA groups was successively significantly increased （Hc = 256.25, P 〈 0.001 ）. The gray value of TH （＋） fibers in the NS, MT ＋ 6-OHDA, N ＋ 6-OHDA, and PX ＋ 6-OHDA groups was also successively significantly increased （F= 99.33, P 〈 0.001 ）. The staining intensities of Bax and Bcl-2 were as follows： Group NS ＋/＋, Group MT ＋ 6-OHDA ＋＋/＋, Group N ＋ 6-OHDA ＋＋/＋, and PX ＋ 6-OHDA ＋＋＋/＋. The concentrations of MDA in the NS, MT ＋ 6-OHDA, N ＋ 6-OHDA, and PX ＋ 6-OHDA groups were significantly increased in sequence （Hc = 296.309, P 〈 0.001 ）. Conclusions： Neuronal

关键词： medial prefrontal cortex Melatonin Pinealectomy Tyrosine Hydroxylase Ventral Tegmental Area

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Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder A proton magnetic resonance spectroscopy study

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Neural Regeneration Research 2012年第36期7卷 2929-2936页

作者： Osman zdel Demet Kalayci Gülfizar Szeri-Varma Yilmaz Kiroglu Selim Tümkaya Tuge Toker-Ugurlu Department of Psychiatry Faculty of MedicinePamukkale University Department of Psychiatry Antalya Training and Research Hospital Department of Radiology Faculty of MedicinePamukkale University

The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.

关键词： bipolar disorder proton magnetic resonance spectroscopy medial prefrontal cortex N-asetylaspartate choline creatine degradation mood disorder neurochemical metabolite illness duration neural regeneration

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Anticipatory activity in rat medial prefrontal cortex during a working memory task

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Neuroscience Bulletin 2012年第6期28卷 693-703页

作者： Wenwen Bai Tiaotiao Liu Hu Yi Shuangyan Li Xin Tian School of Biomedical Engineering Tianjin Medical University Laboratory of Neuroengineering Research Center of Basic MedicineTianjin Medical University

Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role. This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly in- creased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate （10.86 ± 1.82 spikes/ bin） was higher than the post-event rate （8.17 ± 1.15 spikes/bin）（P 〈0.05）. However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

关键词： anticipatory activity working memory rat medial prefrontal cortex neuronal ensemble

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APP regulates up state in medial prefrontal cortex

APP regulates up state in medial prefrontal cortex

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中国神经科学学会第十届全国学术会议

作者： Qing-Wei HUO Quan-Sheng HE Cheng LONG Li YANG School of Life Sciences South China Normal University

Objective Amyloid precursor protein(APP) has been strongly imphcated in the pathogenesis of Alzheimer’s disease(AD) and is essential in maintaining synaptic *** vast majority of synaptic connections onto neurons in the cerebral cortex arise from other cortical neurons,both excitatory and inhibitory,forming local and distant’recurrent’ *** networks spontaneously fluctuate between persistently active up state and quiescent down state,which predicts that local recurrent networks show balance between recurrent excitation and *** evidence suggests that the cognitive deficit and memory loss in early stages of AD are due to synaptic failure and functional changes in the activity of neuronal ***,whether APP physiologically regulates recurrent excitation within medial prefrontal circuits remains *** Briefly,data were obtained from medial prefrontal cortex(mPFC) in wild type(WT) and APP knock out(APP) mice aged postnatal day 30-60 anesthetized with chloral hydrate(i.p.400 mg/kg).In vivo intracellular recordings were carried out with sharp microelectrodes containing 2M potassium acetate with resistances ranging between 60-90MΩ.Intracellular electrodes were placed in the mPFC(in mm from ***:+0.130.23,LP:00.1,DV:-0.52.0).Results(1) up state durations are significantly longer in APP mice as compared to WT controls.(2) Up and Down state membrane potentials are significantly more depolarized in APP neurons than in WT *** Taken together,our data suggest that APP deletion results in increased mPFC excitabihty,which might be due to reduced inhibitory synaptic transmission,leading to imbalance between recurrent excitation and inhibition in mPFC.

关键词： Alzheimer’s disease amyloid precursor protein medial prefrontal cortex up state down state in vivo intracellular recording

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α2A-adrenoceptors activation enhances excitability of pyramidal neurons in the medial prefrontal cortex of rats

α2A-adrenoceptors activation enhances excitability of pyram...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hou-Cheng ZHOU~1,Bao-Ming LI~(1,2,*),Xue-Han ZHANG~(1,*) 1 Institute of Neurobiology & State Key Laboratory of Medical Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China 2 Center for Neuropsychiatric Diseases,Institute of Life Science,Nanchang University,Nanchang 330031,China

Stimulation ofα-adrenoceptors in the medial prefrontal cortex(mPFC)improves working memory *** improvement is accompanied by a selective increase in the activity of mPFC neurons during delay ***,the cellular mechanisms responsible for this enhanced response are largely *** the present study,we recorded action potential in the pyramidal neurons of mPFC slice,using whole-cell current clamp recording *** results show that stimulation ofα-adrenoceptors enhances intrinsic excitability of neurons.

关键词： α2A-adrenoceptors intrinsic excitability medial prefrontal cortex rat

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A novel mechanism of methylphenidate on regulating excitatory synaptic transmission in layerⅣ/Ⅴpyramidal cells of the rat medial prefrontal cortex

A novel mechanism of methylphenidate on regulating excitator...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Chun-Lei ZHANG~1,Ze-Jun FENG~1,Xiao-Hua JI~1,Xue-Han ZHANG~1,Bao-Ming LI~(1,2) 1 Laboratory of Higher Brain Functions,Institute of Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China 2 State Key Laboratory of Medical Neurobiology,Institutes of Brain Science,Fudan University, Shanghai 200032,China

＜正＞Objective Methylphenidate（MPH）,a reuptake inhibitor of dopamine（DA） and norepinephrine（NE）,is widely used as a therapeutic drug for the attention deficit hyperactivity disorder（ADHD）.However,the role of MPH in regulating excitatory synaptic transmission on the prefrontal cortex（PFC） neurons is poorly *** In the present study,we examined the effect of MPH on excitatory synaptic transmission in layerⅣ/Ⅴpyramidal cells of rat medial prefrontal cortex（mPFC） by using whole-cell patch-clamp *** Bath application of MPH（50 umol/L） produced a significant enhancement in the evoked excitatory postsynaptic currents（eEPSC’s） mediated by ionotropic glutamate receptors in layerⅣ/Ⅴpyramidal cells of the *** addition,MPH（50 umol/L） significantly enhanced both NMDA-receptor and non-NMDA-receptor mediated *** the catecholamine-depleted slices,MPH（50 umol/L） significantly enhanced NMDA-receptor mediated eEPSC,but produced no effect on non-NMDA-receptor mediated eEPSC. To further determine the existence of a post-synaptic mechanism underlying the MPH-induced enhancement of NMDAR and non-NMDA-R mediated synaptic transmission,MPH（50 umol/L） significantly enhanced the NMDA-induced currents,and produced no effect on the glutamate-induced non-NMDA-receptor ***,sigma-1 receptor antagonists could inhibit the effect of MPH in regulating the NMDA-induced *** The present study provides the first novel electrophysiological demonstration that treatment with MPH facilitates excitatory synaptic transmission in the mPFC through both pre- and post-synaptic mechanisms.

关键词： methylphenidate EPSC medial prefrontal cortex sigma-1 receptor rat

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