检索结果-南通市图书馆

Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

引用

Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra Tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun Diao Yanping Zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central Hospital School of Life Sciences Guangzhou University School of Life Sciences South China Normal University Guangzhou Hongai Cultural Development Inc. 5. Yinguo Health Management Team College of Biophotonics South China Normal University

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual tapping. The sounds the singing bowls produce have been shown to enhance relaxation and reduce anxiety. However, the underlying mechanism remains unclear. In this study, we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like behaviors. We then supplied treatment with singing bowls in a bottomless cage placed on the top of a cushion. We found that unlike in humans, the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice, while individual vibration components did. Additionally, the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice, decreased the level of γ-aminobutyric acid A(GABA) receptor α 1 subtype, reduced the level of CaMKII in the prefrontal cortex, and increased the number of GABAergic interneurons. At the same time, electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep deprivation. Results from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats

引用

Animal Models and Experimental Medicine 2022年第3期5卷 274-280页

作者： Yu Zhang Xiuping Sun Changsong Dou Xianglei Li Ling Zhang Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina National Human Diseases Animal Model Resource Center BeijingChina Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases BeijingChina International Center for Technology and Innovation of animal model BeijingChina Changping National laboratory(CPNL) BeijingChina

Object:Early-life neglect has irreversible emotional effects on the central nervous *** this work,we aimed to elucidate distinct functional neural changes in me-dial prefrontal cortex(mPFC)of model ***:Maternal separation with early weaning was used as a rat model of early-life *** excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole-cell patch ***:Glutamatergic and GABAergic neurons of mPFC were distinguished by typi-cal electrophysiological *** excitation of mPFC glutamatergic neurons was significantly increased in male groups,while the excitation of mPFC GABAergic neurons was significant in both female and male groups,but mainly in terms of rest membrane potential and amplitude,***:Glutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-life neglect,which can contribute to distinct mechanisms for emotional and cognitive manifestations.

关键词： early-life neglect model GABAergic glutamatergic maternal separation with early weaning medial prefrontal cortex neuronal excitability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder A proton magnetic resonance spectroscopy study

引用

Neural Regeneration Research 2012年第36期7卷 2929-2936页

作者： Osman zdel Demet Kalayci Gülfizar Szeri-Varma Yilmaz Kiroglu Selim Tümkaya Tuge Toker-Ugurlu Department of Psychiatry Faculty of MedicinePamukkale University Department of Psychiatry Antalya Training and Research Hospital Department of Radiology Faculty of MedicinePamukkale University

The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.

关键词： bipolar disorder proton magnetic resonance spectroscopy medial prefrontal cortex N-asetylaspartate choline creatine degradation mood disorder neurochemical metabolite illness duration neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anticipatory activity in rat medial prefrontal cortex during a working memory task

引用

Neuroscience Bulletin 2012年第6期28卷 693-703页

作者： Wenwen Bai Tiaotiao Liu Hu Yi Shuangyan Li Xin Tian School of Biomedical Engineering Tianjin Medical University Laboratory of Neuroengineering Research Center of Basic MedicineTianjin Medical University

Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role. This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly in- creased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate （10.86 ± 1.82 spikes/ bin） was higher than the post-event rate （8.17 ± 1.15 spikes/bin）（P 〈0.05）. However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

关键词： anticipatory activity working memory rat medial prefrontal cortex neuronal ensemble

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Melatonin Levels on Neurotoxicity of the medial prefrontal cortex in a Rat Model of Parkinson＇s Disease

引用

Chinese Medical Journal 2017年第22期130卷 2726-2731页

作者： Yan Li Shu-Mei Wang Lei Guo Jian Zhu Ying Wang Lei Li Yan-Xin Zhao Department of Neurology Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China General Medical Teaching and Research Section Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China Department of Medical Imaging Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China Department of Medical Imaging Shandong Provincial Hospital Jinan Shandong 250014 China

Background： Damage of the medial prefrontal cortex （mPFC） results in similar characteristics to the cognitive deficiency seen with the progress of Parkinson＇s disease （PD）. Since the course of mPFC damage is still unclear, our study aimed to investigate the effects of melatonin （MT） on neurotoxicity in the mPFC of a rat model of PD. Methods： One hundred and fifty-four normal, male Wistar rats were randomly divided into the following five groups： normal ＋ normal saline （NS）, normal ＋ 6-hydroxydopamine （6-OHDA）, sham pinealectomy （PX）＋ 6-OHDA, PX ＋ 6-OHDA, and MT ＋ 6-OHDA. 6-OHDA was injected into the right substantia nigra pars compacta （SNc） and ventral tegmental area （VTA） of each group, except normal ＋ NS, 60 days after the PX. In the MT treatment group, MT was administered immediately after the intraperitoneal injection at 4 p.m. every day, for 14 days. Neuronal apoptosis in the mPFC was exalnined using the TUNEL method, while the expression oftyrosine hydroxylase （TH）, Bax, and Bcl-2 in this region was measured using immunohistochemistry. The concentration of malondialdehyde （MDA） in the mPFC was examined using the thioharbituric acid method. Results： Rats in the normal ＋ 6-OHDA and sham PX ＋ 6-OHDA groups were combined into one group （Group N ＋ 6-OHDA） since there was no significant discrepancy between the groups for all the detected parameters. Apoptosis of cells in the NS, MT ＋ 6-OHDA, N ＋ 6-OH DA, and PX ＋ 6-OHDA groups was successively significantly increased （Hc = 256.25, P 〈 0.001 ）. The gray value of TH （＋） fibers in the NS, MT ＋ 6-OHDA, N ＋ 6-OHDA, and PX ＋ 6-OHDA groups was also successively significantly increased （F= 99.33, P 〈 0.001 ）. The staining intensities of Bax and Bcl-2 were as follows： Group NS ＋/＋, Group MT ＋ 6-OHDA ＋＋/＋, Group N ＋ 6-OHDA ＋＋/＋, and PX ＋ 6-OHDA ＋＋＋/＋. The concentrations of MDA in the NS, MT ＋ 6-OHDA, N ＋ 6-OHDA, and PX ＋ 6-OHDA groups were significantly increased in sequence （Hc = 296.309, P 〈 0.001 ）. Conclusions： Neuronal

关键词： medial prefrontal cortex Melatonin Pinealectomy Tyrosine Hydroxylase Ventral Tegmental Area

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the medial prefrontal cortex

引用

Neuroscience Bulletin 2020年第6期36卷 570-584页

作者： Bin Yu Bo Yuan Jian-Kun Dai Tian-lin Cheng Sheng-Nan Xia Ling-Jie He Yi-Ting Yuan Yue-Fang Zhang Hua-Tai Xu Fu-Qiang Xu Zhi-Feng Liang Zi-Long Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Molecular and Human Genetics Howard Hughes Medical InstituteBaylor College of MedicineHoustonTX 77030USA Wuhan Institute of Physics and Mathematics Chinese Academy of SciencesWuhan 430071China

Methyl-CpG binding protein 2(MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA *** of MECP2-containing genomic segments causes MECP2 duplication syndrome,a severe neurodevelopmental disorder characterized by intellectual disability,motor dysfunction,heightened anxiety,epilepsy,autistic phenotypes,and early *** of the abnormal phenotypes in adult mice with MECP2 duplication(MECP2-TG) by normalizing the MeCP2 levels across the whole brain has been ***,whether different brain areas or neural circuits contribute to different aspects of the behavioral deficits is still ***,we found that MECP2-TG mice showed a significant social recognition deficit,and were prone to display aversive-like behaviors,including heightened anxiety-like behaviors and a fear generalization *** addition,reduced locomotor activity was observed in MECP2-TG ***,appetitive behaviors and learning and memory were comparable in MECP2-TG and wild-type *** magnetic resonance imaging illustrated that the differences between MECP2-TG and wild-type mice were mainly concentrated in brain areas regulating emotion and social *** used the CRISPR-Cas9 method to restore normal MeCP2 levels in the medial prefrontal cortex(mPFC) and bed nuclei of the stria terminalis(BST) of adult MECP2-TG mice,and found that normalization of MeCP2 levels in the mPFC but not in the BST reversed the social recognition *** data indicate that the mPFC is responsible for the social recognition deficit in the transgenic mice,and provide new insight into potential therapies for MECP2 duplication syndrome.

关键词： MECP2 duplication medial prefrontal cortex Social recognition deficit CRISPR-Cas9

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

α2A-adrenoceptors activation enhances excitability of pyramidal neurons in the medial prefrontal cortex of rats

α2A-adrenoceptors activation enhances excitability of pyram...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hou-Cheng ZHOU~1,Bao-Ming LI~(1,2,*),Xue-Han ZHANG~(1,*) 1 Institute of Neurobiology & State Key Laboratory of Medical Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China 2 Center for Neuropsychiatric Diseases,Institute of Life Science,Nanchang University,Nanchang 330031,China

Stimulation ofα-adrenoceptors in the medial prefrontal cortex(mPFC)improves working memory *** improvement is accompanied by a selective increase in the activity of mPFC neurons during delay ***,the cellular mechanisms responsible for this enhanced response are largely *** the present study,we recorded action potential in the pyramidal neurons of mPFC slice,using whole-cell current clamp recording *** results show that stimulation ofα-adrenoceptors enhances intrinsic excitability of neurons.

关键词： α2A-adrenoceptors intrinsic excitability medial prefrontal cortex rat

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pre- and post-synaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer Ⅴ/Ⅵ pyramidal neurons of the medial prefrontal cortex of rats

Pre- and post-synaptic beta-adrenergic activation enhances e...

引用

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Xiao-Hua JI~*,Xiao-Hua CAO~*,Chun-Lei ZHANG,Ze-Jun FENG,Xue-Han ZHANG,Lan MA,Bao-Ming LI Institute of Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China

Abstractive:The present study investigated the modulation by beta-adrenoceptors(beta-AR’s) of excitatory synaptic transmission in layerⅤ/Ⅵpyramidal neurons of the rat medial prefrontal cortex(mPFC),using whole-cell patch clamp ***(ISO),a selective beta-AR agonist,induced a significant increase in the frequency of spontaneous excitatory post-synaptic currents(sEPSC’s) and miniature excitatory post-synaptic currents(mEPSC’s),which could be blocked by the beta-AR antagonist *** ISO facilitation of the frequency of mEPSC’s no longer appeared when the voltage-gated Ca channel blocker cadmium was *** significantly enhanced the evoked excitatory post-synaptic currents(eEPSC’s) mediated by non-NMDA receptors and NMDA *** also enhanced the currents induced by pressure- or bath-applied *** ISO facilitation of NMDA-R mediated eEPSC and NMDAinduced current was partly or completely blocked in the presence of Rp-cAMPS,a protein kinase A(PKA) *** induced a marked decrease in the paired-pulse facilitation of the non-NMDA-R and NMDA-R mediated eEPSC’*** present study provides the first electrophysiological demonstration that activation of beta-AR’s facilitates excitatory synaptic transmission in the mPFC through both pre- and post-synaptic mechanisms.

关键词： isoproterenol beta-Adrenoceptors EPSC medial prefrontal cortex rat

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Oxytocin receptor involved in the inhibition of oxytocin on methamphetamine-induced glutamate release in medial prefrontal cortex of mouse studied by microdialysis

Oxytocin receptor involved in the inhibition of oxytocin on ...

引用

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ying-Xu DONG,Jia QI,Jing-Yu YANG,Fang WANG,Ya-Nan ZHAO,Zheng CAO,Chun-Fu WU~* Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China

＜正＞Objective Recent studies showed that the oxytocin（OT）,a neurohypophyseal neuropeptide which affected adaptive central nervous system processes related to drug addiction,blocked glutamate *** present study was designed to investigate the effects of OT and atosiban（Ato）,a selective inhibitor of OT,on extracellular glutamate （Glu） release induced by methamphetamine（MAP） in the medial prefrontal cortex（mPFC） of *** The level of Glu was determined by microdialysis coupled to high performance liquid chromatography and fluorescence *** OT（2.5μg/mouse,i.c.v.） attenuated the Glu release induced by MAP（2.0 mg/kg,i.p.） in mPFC at the dose that did not modify the basal release of *** effect could be antagonized by Ato at a dose of 10.0μg/mouse,which did not affect the basal release of *** This study gives the first evidence that oxytocin receptor is involved in the inhibition of OT on MAP-induced Glu release in mouse mPFC.

关键词： oxytocin methamphetamine glutamate medial prefrontal cortex microdialysis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Change of extracellular glutamate in the medial prefrontal cortex in psychological dependence induced by methamphetamine

Change of extracellular glutamate in the medial prefrontal c...

引用

中国药理学会第十次全国学术会议

作者： Wen-An Han,Chun-Fu Wu,Fang Wang,Fan-Gang Wang,Jing-Yu Yang~* (Department of Pharmacology,Shenyang Pharmaceutical University,110016 Shenyang,P.R.China)

Methamphetamine(MAP) is abused in the world,which remains a major social ***-induced psychological dependence is the main reason of *** of abuse usurp the neuronal circuitry involved in motivation and reward,leading to aberrant engagement of learning *** this study conditioned place preference (CPP) model including acquisition,expression,extinction and reinstatement procedures was used to investigate the behavioral change induced by MAP in *** extracellular glutamate(Glu) levels in the medial prefrontal cortex (mPFC) of rats treated with MAP were determined by microdialysis coupled to a HPLC with fluorescence detection *** results show that there is a directly correlation between behavioral changing with extracellular glutamate level in mPFC induced by MAP during CPP acquisition-expression procedure,and Glu-level increasing ratio reaches the peak on CPP expression *** ratio may decrease to the normal level when place preference scores were gradually decreased at the same ***-dose MAP can reinstate the mice anew the high scores in drug-paired *** was found that during 1 hour after the injection autonomic activities was increased. With the increasing Glu-level increasing ratio,the CPP-score was *** of ethology and neurobiochemistry indicated that changing of mPFC extracellular Glu which can change behavioral effect is closely related to the learning and memory mechanism of the excitability neurotransmission in the brain in methamphetamine-induced psychological dependence.

关键词： glutamate medial prefrontal cortex conditioned place preference methamphetamine direct correlation psychological dependence

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：