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mechanical stress-induced Hippo signaling in respect to primordial follicle development and polycystic ovary syndrome pathogenesis

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Reproductive and Developmental Medicine 2022年第2期6卷 121-128页

作者： Ling-Jin Xia Jing Du NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200011China

Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive disease that can cause infertility. The Hippo signaling pathway, a network highly conserved throughout evolution, maintains the balance between follicle proliferation and dormancy. Dynamic changes in primordial follicles cannot occur without the participation of biological signals and mechanical force;however, little is known about the mechanism by which biomechanical signaling triggers PCOS, especially in the context of primordial follicle development. To investigate the contribution of mechanical stress and the Hippo signaling pathway to the onset of PCOS, we searched the literature via the PubMed database, and inclusion and exclusion criteria were established to ensure the rigor of this research. We eventually included 54 publications in which Hippo signaling and mechanical force were suggested to play a vital role in the development of primordial follicles as well as elucidate the pathogenesis of PCOS. The Hippo pathway modulating follicle growth can be perturbed via extracellular mechanical stress caused by the stiff ovarian cortical environment in PCOS. Clinical intervention targeting the Hippo pathway can alter the activity of core Hippo members, such as the Yes-associated protein/transcriptional co-activator PDZ-binding motif complex. In some patients with PCOS, follicle overactivation can be attributed to the dysfunction of Hippo signal transduction. PCOS, a condition with various patterns, cannot be accurately explained by a single, specific mechanism. The present review identifies potential targets and therapeutic strategies for PCOS.

关键词： Polycystic ovary syndrome Hippo signaling pathway mechanical forces Extracellular matrix

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Sclerostin regulation:a promising therapy for periodontitis by modulating alveolar bone

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Chinese Medical Journal 2020年第12期133卷 1456-1461页

作者： Tian-Jiao Li Rui Wang Qin-Yang Li Chun-Yu Li Li Jiang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

Periodontitis is one of the most prevalent epidemics affecting human health and life recently,and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars.In recent years,sclerostin,a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation,has been a research hotspot.This article summarizes the researches on sclerostin in periodontitis development in recent years.Among them,sclerostin has been shown to be a critical negative regulator of bone formation,thereby inhibiting bone remodeling in periodontitis development,and is closely associated with tooth movement.Besides,evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from resorption.Regulation of sclerostin expression is a novel,promising treatment for periodontitis and addresses several complications seen with traditional therapies;accordingly,many drugs with similar mechanisms have emerged.Moreover,the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising approach.There are also a lot of drugs that regulate sclerostin.Anti-sclerostin antibody(Scl-Ab)is the most direct one that inhibits bone resorption caused by sclerostin.At present,drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and osteoporosis.Therefore,the application of sclerostin in the oral field is just around the corner,which provides a new therapeutic bone regulation strategy in oral and general health.

关键词： Sclerostin Periodontitis Orthodontics Tooth movement mechanical forces Adjunctive therapy

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Unveiling the morphogenetic code:A new path at the intersection of physical energies and chemical signaling

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World Journal of Stem Cells 2021年第10期13卷 1382-1393页

作者： Riccardo Tassinari Claudia Cavallini Elena Olivi Valentina Taglioli Chiara Zannini Carlo Ventura National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems–ELDOR LABBologna 40129Italy

In this editorial,we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem cells.In particular,we focus on the biological relevance of bioelectricity in the pattern control that orchestrates both developmental and regenerative pathways.To this end,the narrative starts from the dawn of the first studies on animal electricity,reconsidering the pioneer work of Harold Saxton Burr in the light of the current achievements.We finally discuss the most recent evidence showing that bioelectric signaling is an essential component of the informational processes that control pattern specification during embryogenesis,regeneration,or even malignant transformation.We conclude that there is now mounting evidence for the existence of a Morphogenetic Code,and that deciphering this code may lead to unprecedented opportunities for the development of novel paradigms of cure in regenerative and precision medicine.

关键词： Physical energies Stem cells Bioelectricity Electromagnetic radiation mechanical forces Morphogenetic code

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