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Effect of continuous positive airway pressure treatment on serum adiponectin level and mean arterial pressure in male patients with obstructive sleep apnea syndrome

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Chinese Medical Journal 2007年第17期120卷 1477-1481页

作者： ZHANG Xi-long YIN Kai-sheng LI Chong JIA En-zhi LI Yan-qun GAO Zhao-fang Departmemt of Respiratory Medicine First Affliated Hospital ofNanjing Medical University Nanjing 210029 China Departmemt of Cardiology First Affiliated Hospital of NanjingMedical University Nanjing 210029 China

Background Recent research suggested that obstructive sleep apnea syndrome （OSAS） might be independently associated with hypoadiponectinemia, which was linked to some complications of OSAS, such as hypertension, diabetes etc. This study was conducted to investigate the effect of continuous positive airway pressure （CPAP） treatment on changes of both serum adiponectin levels and mean arterial pressure and their possible links in male OSAS patients. Methods Twenty-three adult male patients with moderate-to-severe OSAS but without obesity, coronary heart disease and diabetes were recruited. Their blood samples were collected and morning mean arterial pressure （MAP） was measured before CPAP treatment and on day 3, 7, 14 of CPAP treatment respectively. The serum adiponectin concentration was tested with radioimmunoassay. Results Compared with the serum adiponectin level before CPAP treatment, no significant change was found in OSAS patients on day 3 and day 7 of CPAP treatment （P〉0.05）. It was not until day 14 of CPAP treatment did a significant elevation in serum adiponectin level occur （P〈0.01）. meanwhile, the MAP showed no statistically significant difference among its levels before CPAP, on day 3 and day 7 of CPAP treatment （P〉0.05）. However, on day 14 of CPAP treatment, a significantly lower MAP than that obtained before treatment was observed （P〈0.05）. Conclusions CPAP treatment can gradually reverse hypoadiponectinemia and reduce MAP in OSAS patients. Hypoadiponectinemia might be involved in the pathogenesis of OSAS-mediated hypertension.

关键词： obstructive sleep apnea syndrome continuous positive airway pressure adiponectin mean arterial pressure

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Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats

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Acta Pharmacologica Sinica 2006年第3期27卷 294-298页

作者： Lin XIAO Yu-ming WU~1 Hao ZHANG Yi-xian LIU Rui-rong HE Department of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China Department of Physiology Institute of Basic Medicine Hebei Medical University Shijiazhuang China

Aim:To study effects of hydrogen sulfide(H2S)on the carotid sinus baroreflex(CSB).Methods:The functional curve of the carotid sinus baroreflex was mea-sured by recording changes in arterial pressure in anesthetized male rats withperfused carotid ***:H2S(derived from sodium hydrosulfide)at con-centrations of 25,50,and 100 μmol/L facilitated the CSB,shifting the functionalcurve of the baroreflex downward and to the *** was a marked increase inpeak slope(PS)and reflex decrease in blood pressure(RD).Effects were *** with glibenclamide(20 μtmol/L),a KATPchannelblocker,abolished the above effects of H2S on *** with Bay K8644(an agonist of calcium channels;500 nmol/L)eliminated the effect of H2S on *** inhibitor of cystathionine γ-lyase(CSE),DL-propargylglycine(PPG;200μmol/L),inhibited CSB in male rats and shifted the functional curve of the baroreflexupward and to the ***:These data suggest that exogenous H2Sexerts a facilitatory role on isolated CSB through opening KATPchannels andfurther closing the calcium channels in vascular smooth *** H2Smay activate the activity of the CSB in vivo.

关键词： hydrogen sulfide KATP channel opener glibenclamide carotid baroreflex mean arterial pressure Bay K8644

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Prognostic value of hemodynamic indices in patients with sepsis after fluid resuscitation

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World Journal of Clinical Cases 2021年第13期9卷 3008-3013页

作者： He-Ping Xu Xiao-An Zhuo Jin-Jian Yao Duo-Yi Wu Xiang Wang Ping He Yan-Hong Ouyang Department of Emergency Medicine Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina

BACKGROUND Sepsis usually causes hemodynamic *** index is one of the factors to identify the severity of sepsis and an important parameter to guide the procedure of fluid *** present study investigated whether the assessment of hemodynamic indices can predict the outcomes of septic patients undergoing resuscitation *** To evaluate the prognostic value of hemodynamic indices in patients with sepsis after fluid *** A retrospective study was conducted in 120 patients with sepsis at Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University between October 2016 and October *** patients were treated with sodium chloride combined with dextran glucose injection for fluid ***’hemodynamic parameters were monitored,including heart rate(HR),cardiac index(CI),systemic vascular resistance index(SVRI),mean arterial pressure(MAP),central venous pressure(CVP),and central venous oxygen *** prognostic value of hemodynamic indices was determined based on the prognosis *** During fluid resuscitation,86 patients developed septic shock and 34 did ***-nine patients survived and 21 patients died at 28 d after the *** rate,CI,mean arterial pressure,SVRI,and CVP were higher in patients with septic shock and patients who died from septic shock than in non-shock patients and patients who survived,and central venous oxygen saturation was lower in patients with shock and patients who died than in non-shock patients and thesurvivors (P < 0.05). When prognosis was considered as a dependent variable andhemodynamic parameters was considered as independent variables, the results ofa logistic regression analysis showed that CI, SVRI, and CVP were independentrisk factors for septic shock, and CI was an independent risk factor for 28-dmortality (P < 0.05).CONCLUSIONHemodynamic indices can be used to evaluate the prognosis of septic patientsafter fluid resusc

关键词： Sepsis Fluid resuscitation Cardiac index Systemic vascular resistance index mean arterial pressure

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H_1 and H_2 receptors in the locus ceruleus are involved in the intracere-broventricular histamine-induced carotid sinus baroreceptor reflex reset-ting in rats

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Neuroscience Bulletin 2006年第4期22卷 209-215页

作者： Guo-Qing WANG Wan-Ping SUN Yong-Jin ZHU Rong ZOU Xi-Ping ZHOU Department of Physiology Medical School Soochow University Suzhou 215123 China

Objective To investigate the role of H1 and H2 receptors in the locus ceruleus （LC） in carotid sinus baroreceptor reflex （CSR） resetting induced by intracerebroventricular （i.c.v.） injection of histamine （HA）. Methods The left and right carotid sinus regions were isolated from the systemic circulation in 18 male Sprague-Dawley rats anesthetized with pentobarbital sodium. The intracarotid sinus pressure （ISP） was altered in a stepwise manner in vivo. ISP-mean arterial pressure （MAP） relationship curve and its characteristic parameters were constructed by fitting to the logistic function with five parameters. The changes in CSR performance induced by i.c.v. HA and the effects of pretreatment with H1 or H2 receptors selective antagonist, chlorpheniramine （CHL） or cimetidine （CIM） into the LC, on the responses of CSR to HA were examined. Results I.c.v. HA （100 ng in 5 μl） significantly shifted the ISP-MAP relationship curve upwards （P 〈 0.05） and obviously decreased the value of the reflex parameters such as MAP range and maximum gain （P 〈 0.05）, but increased the threshold pressure, saturation pressure and ISP at maximum gain （P 〈 0.05）. The pretreatment with CHL （0.5 μg in 1 μl） or CIM （1.5 μg in 1 μl） into the LC could obviously attenuate the changes mentioned above in CSR performance induced by HA, but the alleviative effect of CIM was less remarkable than that of CHL （P 〈 0.05）. Respective microinjection of CHL or CIM alone into the LC with the corresponding dose and volume did not change CSR performance significantly （P 〉 0.05）. Conclusion Intracerebroventricular administration of HA results in a rapid resetting of CSR and a decrease in reflex sensitivity, and the responses of CSR to HA may be mediated, at least in part, by H1 and H2 receptors activities in the LC, especially by H1 receptors. Moreover, the effects of the central HA on CSR might be related to a histaminergic descending pathway from the hypothalamus to LC.

关键词： carotid sinus baroreceptor reflex histamine intracerebroventricular injection H1 receptor H2 receptor locus ceruleus mean arterial pressure

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Management of sepsis in a cirrhotic patient admitted to the intensive care unit:A systematic literature review

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World Journal of Hepatology 2023年第6期15卷 850-866页

作者： Nkola Ndomba Jonathan Soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Sepsis is a severe medical condition that occurs when the body's immune system overreacts to an infection,leading to life-threatening organ ***"Third international consensus definitions for sepsis and septic shock(Sepsis-3)"defines sepsis as an increase in sequential organ failure assessment score of 2 points or more,with a mortality rate above 10%.Sepsis is a leading cause of intensive care unit(ICU)admissions,and patients with underlying conditions such as cirrhosis have a higher risk of poor ***,it is critical to recognize and manage sepsis promptly by administering fluids,vasopressors,steroids,and antibiotics,and identifying and treating the source of *** To conduct a systematic review and meta-analysis of existing literature on the management of sepsis in cirrhotic patients admitted to the ICU and compare the management of sepsis between cirrhotic and non-cirrhotic patients in the *** This study is a systematic literature review that followed the PRISMA statement's standardized search *** search for relevant studies was conducted across multiple databases,including PubMed,Embase,Base,and Cochrane,using predefined search *** reviewer conducted the initial search,and the eligibility criteria were applied to the titles and abstracts of the retrieved *** selected articles were then evaluated based on the research objectives to ensure relevance to the study's *** The study findings indicate that cirrhotic patients are more susceptible to infections,resulting in higher mortality rates ranging from 18%to 60%.Early identification of the infection source followed by timely administration of antibiotics,vasopressors,and corticosteroids has been shown to improve patient *** is a useful biomarker for diagnosing infections in cirrhotic ***,presepsin and resistin have been found to be reliable markers of bacterial infection in patients with decompensated li

关键词： Sepsis Septic shock Cirrhosis Sequential organ failure assessment score mean arterial pressure Intensive care unit

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Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study

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World Journal of Transplantation 2021年第4期11卷 114-128页

作者： Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu Department of Anesthesiology University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Department of Surgery Miami Transplant Institute/University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Division of Nephrology of the Department of Medicine University of Miami/Jackson Memorial HospitalMiamiFL 33136United States

BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney *** exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is *** To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 *** primary outcome was the occurrence of *** The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressuremean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine.

关键词： Delayed graft function Outcome Kidney transplant Risk factors Phenylephrine mean arterial pressure

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Role of Nuclear Transcription Factor-кB in Endotoxin induced Shock in Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第2期25卷 174-177页

作者：王进杨光田 Emergency Department Tongji Hospital Tongji Medical College Huazhong University ofScience and Technology Wuhan 430030 China

Summary: To investigate the role of NF-κB in endotoxic shock in rats, the model of endotoxin-shock rats was induced by intravenous infusion of lipopolysaccharide (LPS). 1 h, 2 h, 4 h and 6 h after LPS injection, the activation of NF-κB in blood mononuclear cells and the content of TNF-α and IL-6 in plasma was detected by enzyme-linked immunoadsordent assay (ELISA). The level of mean arterial pressure (MAP) and the histopathological changes of lung and liver were also observed. The activation of NF-κB in mononuclear cells increased 1 h after LPS injection and reached its peak 2 h after the injection, and its level was higher than that of normal group. The level of TNF-α was increased 1 h after the infusion and peaked 2 h after the injection, and its level was higher than that of normal group after LPS infusion. The content of IL-6 increased gradually with time, the IL-6 level was higher than that of normal group after LPS injection. MAP was decreased gradually with time and its level was lower than that of normal group after LPS injection. Pathological examination showed that endotoxic shock could cause pulmonary alveolar hemorrhage, edema and infiltration of inflammatory cell in lung tissue and congestion, edema, capillary dilation and inflammatory cell infiltration in liver tissue. It is concluded that NF-κB can up-regulate the expression of TNF-α and IL-6 in plasma and play an important role in endotoxin-induced shock in rats.

关键词： endotoxic shock mononuclear cells lipopolysaccharide nuclear factor Kappa B tumor necrosis factor-α Interleukin-6 mean arterial pressure

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Screening and Prevention of Preeclampsia

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Maternal-Fetal Medicine 2019年第1期1卷 25-30页

作者： Liona C.Poon Daljit Sahota Department of Obstetrics and Gynaecology The Chinese University of Hong KongShatinHongKong 999077China

Preeclampsia(PE)is a multisystem disorder of pregnancy classically characterized by hypertension with significant proteinuria after 20 weeks'*** disorder is one of the leading causes of maternal and perinatal morbidity and *** can be subdivided into preterm PE(with delivery at<37 weeks'gestation)and term PE(with delivery at≥37 weeks'gestation).Preterm PE is associated with a higher risk of adverse maternal and perinatal outcomes than term *** method of screening as recommended by professional guidelines has limited predictive performance and therefore should be updated to reflect recent scientific evidence that the target of screening should be preterm PE,the best way to identify the high-risk group is the Bayes-based method that combines maternal risk factors and biomarkers,the threshold should be set at screen positive rate of 10%,aspirin should be started before 16 weeks'gestation,and the daily dose should be higher than 100mg.

关键词： Preeclampsia First trimester Screening mean arterial pressure Uterine artery pulsatility index Placental growth factor

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右美托咪定对氯胺酮药效学的影响（英文）

右美托咪定对氯胺酮药效学的影响（英文）

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全国第三次麻醉药理学术会议

作者：蔡慧明韩平平戴体俊徐州医学院药学院徐州医学院麻醉药理教研室

目的研究右美托咪定对氯胺酮药效学的影响,为二者组成复合麻醉提供实验依据。方法采用热板法和扭体法分别观察右美托咪定与氯胺酮合用对小鼠热板痛阈及扭体次数的影响;采用翻正反射法观察右美托咪定与氯胺酮合用对小鼠入睡率及睡眠时间... 详细信息

目的研究右美托咪定对氯胺酮药效学的影响,为二者组成复合麻醉提供实验依据。方法采用热板法和扭体法分别观察右美托咪定与氯胺酮合用对小鼠热板痛阈及扭体次数的影响;采用翻正反射法观察右美托咪定与氯胺酮合用对小鼠入睡率及睡眠时间的影响;采用Morris水迷宫观察右美托咪定与氯胺酮合用对小鼠逃避潜伏期的影响;采用RM6240多道生理信号采集处理系统观察右美托咪定与氯胺酮合用对大鼠平均动脉压、心率及呼吸频率的影响;采用序贯法观察右美托咪定与氯胺酮合用对小鼠半数致死量(LD)的影响。此外,以阿替美唑为工具药来分析α受体是否介导右美托咪定与氯胺酮的上述相互作用。结果在热板和扭体实验中,右美托咪定与氯胺酮合用能使小鼠的热板痛阈延长(P0.05)。结论①右美托咪定能够增强氯胺酮的麻醉作用,且α受体可能是该效应的主要受体机制;②右美托咪定与氯胺酮者合用能够稳定心血管及呼吸功能,且前者可能减轻后者的毒性作用。

关键词： Analgesia anterograde amnesia heart rate hypnosis mean arterial pressure

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