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Potential association of long noncoding RNA HA117 with tetralogy of Fallot

Genes & Diseases 2018年第2期5卷 185-190页

作者： Quan Wang Zhili Wang Chun Wu Zhengxia Pan Li Xiang Hang Liu Xin Jin Kerong Tong Shulei Fan Xianqing Jin Ministry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of PediatricsChongqingChina Department of Cardiothoracic Surgery Children’s Hospital of Chongqing Medical UniversityChongqingChina Renal Department and Nephrology Institute Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina

Tetralogy of Fallot(TOF)is a congenital heart disease characterized by abnormal cardiomyocyte differentiation in the right ventricular outflow tract(RVOT),and HA117 is a novel long noncoding RNA(lncRNA)with anti-differentiation *** investigate the potential association of HA117 with TOF,we collected 84 RVOT tissues from patients with *** determined the expression of HA117 in RVOT samples from TOF patients and collected clinical data to conduct a cross-sectional and short-term follow-up *** ratio,Nakata index,and left ventricular end-diastolic volume index(LVEDVI)were negatively correlated with the expression of HA117 based on subgroup analysis,correlation analysis and logistic regression ***,cardiopulmonary bypass(CPB)time and ICU stay were longer in patients with higher expression of HA117 than in patients with lower expression of ***,percentage improvement in SPO2 was significantly reduced in patients with increased HA117 expression at 6 months after *** results suggested that the increased expression of the novel lncRNA HA117 is a risk factor for unfavorable mcgoon ratio,Nakata index and LVEDVI in TOF ***,an increased expression of HA117 might lead to adverse short-term outcomes in TOF patients.

关键词： HA117 Tetralogy of Fallot Long noncoding RNA mcgoon ratio Nakata index

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