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Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

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World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro Ito Kenichi Takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto Department of endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the mayo endoscopic subscore(MES),Ulcerative Colitis endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire colon.AIM To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical remission.METHODS In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were enrolled.The diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for UC.Fecal samples were collected the day before or after the colonoscopy for measurement of FC.endoscopic evaluations were performed using MES,UCEIS,and UCCIS.The primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and FC.The secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal healing.RESULTSFC and UCCIS showed a significant correlation with UCEIS (r = 0.537, P endoscopic scores and biomarkers in predicting r

关键词： Ulcerative colitis mayo endoscopic subscore Ulcerative Colitis endoscopic Index of Severity Ulcerative Colitis Colonoscopic Index of Severity Fecal calprotectin Relapse

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Clinical value of the Toronto inflammatory bowel disease global endoscopic reporting score in ulcerative colitis

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World Journal of Gastroenterology 2023年第48期29卷 6208-6221页

作者： Xin-Yue Liu Zi-Bin Tian Li-Jun Zhang Ai-Ling Liu Xiao-Fei Zhang Jun Wu Xue-Li Ding Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Population and Quantitative Health Sciences(PQHS) School of MedicineCase Western Reserve UniversityClevelandOH 44106United States Department of Gastroenterology Qingdao HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266011Shandong ProvinceChina

BACKGROUND endoscopic evaluation in diagnosing and managing ulcerative colitis(UC)is becoming increasingly important.Several endoscopic scoring systems have been established,including the Ulcerative Colitis endoscopic Index of Severity(UCEIS)score and mayo endoscopic subscore(MES).Furthermore,the Toronto Inflammatory Bowel Disease Global endoscopic Reporting(TIGER)score for UC has recently been proposed;however,its clinical value remains unclear.AIM To investigate the clinical value of the TIGER score in UC by comparing it with the UCEIS score and MES.METHODS This retrospective study included 166 patients with UC who underwent total colonoscopy between January 2017 and March 2023 at the Affiliated Hospital of Qingdao University(Qingdao,China).We retrospectively analysed endoscopic scores,laboratory and clinical data,treatment,and readmissions within 1 year.Spearman’s rank correlation coefficient,receiver operating characteristic curve,and univariate and multivariable logistic regression analyses were performed using IBM SPSS Statistics for Windows,version 26.0(IBM Corp.,Armonk,NY,United States)and GraphPad Prism version 9.0.0 for Windows(GraphPad Software,Boston,Massachusetts,United States).RESULTS The TIGER score significantly correlated with the UCEIS score and MES(r=0.721,0.626,both P<0.001),showed good differentiating values for clinical severity among mild,moderate,and severe UC[8(4-112.75)vs 210(109–219)vs 328(219–426),all P<0.001],and exhibited predictive value in diagnosing patients with severe UC[area under the curve(AUC)=0.897,P<0.001].Additionally,the TIGER(r=0.639,0,551,0.488,0.376,all P<0.001)and UCEIS scores(r=0.622,0,540,0.494,and 0.375,all P<0.001)showed stronger correlations with laboratory and clinical parameters,including C-reactive protein,erythrocyte sedimentation rate,length of hospitalisation,and hospitalisation costs,than MES(r=0.509,0,351,0.339,and 0.270,all P<0.001).The TIGER score showed the best predictability for patients'recent advanced treatment,including systemic corticosteroids,bi

关键词： Ulcerative colitis Toronto Inflammatory Bowel Disease Global endoscopic Reporting score Ulcerative Colitis endoscopic Index of Severity mayo endoscopic subscore Endoscopy Severity

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Comparing the clinical application values of the Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score and Ulcerative Colitis endoscopic Index of Severity(UCEIS)in patients with ulcerative colitis

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Gastroenterology Report 2021年第6期9卷 533-542页

作者： Xiao-Fei Zhang Peng Li Xue-Li Ding Hao Chen Shao-Jun Wang Sheng-Bo Jin Jing Guo Zi-Bin Tian Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong266003P.R.China Department of Urology The Affiliated Hospital of Qingdao UniversityQingdaoShandong266003P.R.China

Background:The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis(UC)has been widely recognized.Over the years,scholars have established several endoscopic scores.Herein,we assessed the clinical application value of the mayo endoscopic subscore(mayo ES),the Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score,and the Ulcerative Colitis endoscopic Index of Severity(UCEIS)score in UC patients,by comparing their correlation with disease activity and their predictive potential for treatment response and clinical outcomes.Methods:UC patients hospitalized from September 2015 to September 2019 were retrospectively analysed.We employed Spearman’s rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical parameters.The receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year readmission.Results:A total of 178 patients were enrolled;most of them(82%)suffered moderate or severe colitis.Among them,48(27%)patients received treatment escalation and 59(33%)were readmitted within 1 year.The DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the mayo ES.The DUBLIN scores significantly differed between patients with mild,moderate,and severe colitis(all Pmayo ES for treatment escalation(both Pmayo ES and DUBLIN scores were found among the three groups(both P>0.05).Conclusion:This

关键词： mayo endoscopic subscore Degree of Ulcerative Colitis Burden of Luminal Inflammation score Ulcerative Colitis endoscopic Index of Severity ulcerative colitis

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