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Atorvastatin attenuates oxidative stress in Alzheimer's disease

Journal of Medical Colleges of PLA(China) 2008年第1期23卷 31-37页

作者： Cai Zhiyou Yan Yong Wang Yonglong Department of Neurology the First Affiliated Hospital of Chongqing Medical University Chong qing 400016China

Objective： To investigate serum level of SOD, MDA, ox-LDL, AchE and Ach in AD, to study atorvastatin influence on serum level of SOD, MDA, ox-LDL, Ache and Ach in AD and its neuroprotection mechanisms. Methods Subjects were divided into： normal blood lipid level group with Alzheimer＇s disease （A）, higher blood lipid level group with Alzheimer＇s disease （AH）, normal blood lipid level Alzheimer＇s disease group with atorvastatin treeatment （AT）, higher blood lipid level Alzheimer＇s disease group with atorvastatin treeatment（AHT）. Ox-LDL was measured by enzyme linked immunosorbent assay; SOD, MDA, ox-LDL, AchE, Ach and blood lipid level in AD was measured by biochemistry. Results： The serum level of MDA, Ache in AH group after atorvastatin treatment is lower ;The serum level of SOD, Ach in AH group is more increased than that of in A group; The serum level of ox-LDL in AH, A groups is lower than that of in A group; The dementia degree is lower after atorvastatin treatment. Conclusion： Atorvastatin can decrease serum level of MDA, AchE and ox-LDL, and increase that of SOD, Ach, and attenuate dementia symptom in AD, especially, with hyperlipemia. The hypothesis of atorvastatin neuroprotection is concluded that atorvastatin may restrain free radical reaction and retard oxidation in AD.

关键词： Atorvastatin Alzheimer's disease Superoxide dismutase matondialdehyde Oxidized low-density lipoprotein

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Role of Lipid Peroxidation in Bacterial Translocation from the Small Intestine after Thermal Injury in Rats

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Journal of Medical Colleges of PLA(China) 1990年第3期5卷 271-277页

作者：彭毅志肖光夏王德旺张雅萍秦孝建 Institute of Burn Medicine Southwest HospitalThird Military Medical UniversityChongqing 630038China

Oxygen-derived free radicals have bran proved to play a role in the intestinalmucosa damage induced by ischemic reperfusion after burns,but their role in thebacterial translocation from the intestine to other organs is not documented so *** intended to investigate this problem on 186rats,which were randomized into 5groups:the normal control group,the group receiving oral Pseudomonas,the group ofsimple burn injury,and the groups of combined oral Pseudomonas and burn injury withor without superoxide dismutase(SOD)*** burn injury was 30% TBSA fullthickness *** oral administered Pseudomonas was labdled with isothiocyanatefor *** animals were killed in the 4th,12th,24th,48th,or 72nd hour afterinjury *** changes of malondialdehyde(MDA)in the ilcal mucosa were ob-served with optical and electron microscope,and bacterial translocation from the intes-tine to the liver and blood stream was traced .The animals with combined injury and simple burns showed a marked increase ofileal mucosal MDA with the peak in the 12th hour accompanied with intense pathologicalchanges in the small intestine;the incidence of bacterial translocation from the intestineto other organs also *** SOD treatment,the MDA levd in the ileal mucosawas significantly lower,the pathological changes in the intestinal mucosa were allevia-ted,and the incidence of bacterial translocation from the intestine was lowered with nolabdled Pseudomonas isolated from the blood *** this study,it was demonstrated that free radicals are one of the factors ofintestinal mucosal damage and bacterial translocation from the intestine after burns,andSOD could protect the intestinal mucosal barrier from being injured and inhibit thebacterial translocation from the intestine.

关键词： burns enterogenous infection lipid peroxidation matondialdehyde superoxide dismutase

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