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maternal Bisphenol B exposure and Mammary Gland Development of Offspring:A Time-Series Analysis

Environment & Health 2023年第4期1卷 278-290页

作者： Xiaotong Ji Peiyun Jiang Yating Li Lihong Su Huifeng Yue Nan Sang Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuanShanxi 030001P.R.China Key Laboratory of Coal Environmental Pathogenicity and Prevention(Shanxi Medical University) Ministry of EducationTaiyuanShanxi 030001P.R.China Department of Pathology Shanxi Provincial People’s HospitalTaiyuanShanxi 030001P.R.China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuanShanxi 030006P.R.China

Breast cancer incidence has increased and become the world’s most prevalent cancer,which is related to abnormal development of mammary glands and thought to be influenced by environment endocrine disruptors such as bisphenol A(BPA).However,whether its substitution,bisphenol B(BPB),has similar effects remains a *** the present study,a maternal exposure model of ICR mice combined time-series RNA-seq analysis was established to explore the underlying correlation among maternal BPB exposure(300μg/kg body weight),mammary gland development,and long-term breast health in *** results showed that BPB exposure disrupted hormonal homeostasis of the female offspring but did not affect the branch development of mammary glands in a time-dependent ***,at postnatal day 90(PND90),BPB exposure resulted in duct dilatation,lobular hyperplasia,and inflammatory cell infiltration and increased the number of hormone receptor-expressing(HR+)luminal cells in ***,the differentially expressed genes in time-series analysis of RNA-seq for mammary glands of the female offspring were enriched in the morphogenesis of branching structures,branching epithelium,and branching morphogenesis of epithelial tubes,which are always considered gland ***,the results of RNA-seq also suggested that progesterone receptor(Pgr)mRNA expression in the BPB group was elevated at PND90,and breast cancer related genes such as GATA binding protein 3(Gata3)and epidermal growth factor receptor(Egfr)were also *** findings suggested that maternal BPB exposure did not accelerate mammary gland development or lead to obvious morphological anomalies of offspring,but it induced pathological changes and altered cancer related gene expression in adult offspring breast.

关键词： Bisphenol B maternal exposure Mammary gland development Hormonal homeostasis Progesterone receptor

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