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Toxicity of manufactured nanomaterials

Particuology 2022年第10期20卷 31-48页

作者： Yaping Liu Shuang Zhu Zhanjun Gu Chunying Chen Yuliang Zhao CAS Key Laboratory for Biomedical Effects of nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China and Institute of High Energy PhysicsBeijing 100190China The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700China

manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical ***,some of the properties have been identified to be closely related to nanomaterial ***"nano-paradox"has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate *** key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio *** this end,we start the present work with a brief intro-duction to nano-bio interactions at different *** on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply ***,advanced analytical methods for studying nano-bio interactions are ***,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are ***,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials.

关键词： manufactured nanomaterial Nanotoxicity Nano-bio interaction nanomaterial property Analytical method Regulation

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