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Study on the antipyretic effect of pushing Tianheshui in young rabbits: focus on the α-MSH-mediated cAMP/PKA/NF-κB signaling pathway

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Journal of Acupuncture and Tuina Science 2024年第6期22卷 447-453页

作者： HUANG Yumei WANG Dejun WANG Wei GAO Juan CHEN Liwei School of Acupuncture-moxibustion Tuina and RehabilitationHunan University of Chinese MedicineChangsha 410208China Nanchang Hongdu Hospital of TCM Jiangxi University of Chinese MedicineNanchang 330006China

Objective:To explore the antipyretic effect and partial mechanism of the pushing Tianheshui manipulation on lipopolysaccharide(LPS)-induced fever in young New Zealand ***:Thirty 50-day-old New Zealand rabbits were randomly assigned to five groups,including a normal group,a model group,a Tuina(Chinese therapeutic massage)group,a Tuina control group,and a drug group,with 6 rabbits in each *** groups except for the normal group received LPS injections through the marginal ear vein to induce *** hour post-modeling,the Tuina and Tuina control groups received pushing Tianheshui manipulation and pushing manipulation on the medial middle of the hind limbs,respectively,administered every hour for a total of 3 *** drug group was given acetaminophen oral liquid via *** temperature was recorded every 30 min for 4.0 h to monitor temperature changes among *** 4.0 h post-modeling,hypothalamus samples from each group were analyzed using Western blotting(WB)and real-time quantitative polymerase chain reaction(RT-qPCR)to measure the relative expression levels ofα-melanocyte-stimulating hormone(α-MSH),melanocortin 4 receptor(MC4R),cyclic adenosine monophosphate(cAMP),protein kinase A(PKA),nuclear factor-κB p65(NF-κB p65),and interleukin(IL)-1βproteins and their ***:Compared to the model group,the Tuina group showed a significant reduction in the anal temperature from 3.5 h to 4.0 h post-modeling(P0.05).The drug group exhibited a significant temperature reduction from 1.5 h to 4.0 h post-modeling(P<0.05).At 4.0 h post-modeling,compared to the model group,the Tuina group showed significantly increased relative expression ofα-MSH and MC4R proteins and mRNAs(P<0.05)and significantly decreased relative expression of cAMP,PKA,NF-κB p65,and IL-1βproteins and mRNAs in the hypothalamus tissue(P<0.05).No significant dif

关键词： Tuina Massage manual therapies Pushing Tianheshui Lipopolysaccharides Fever Rabbits

Observation of the efficacy and safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation for patients with prediabetes

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Journal of Acupuncture and Tuina Science 2022年第1期20卷 58-64页

作者： LI Min PENG Na ZENG Jiaofei ZHOU Ying DENG Yihui HE Qinghu KONG Xiehe Hunan University of Chinese Medicine Changsha 410208China Hunan Traditional Chinese Medical College Zhuzhou 412012China Hunan Want Want Hospital Changsha 410016China 不详

Objective:To observe the safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation in treating patients with prediabetes and its effects on blood glucose and lipid ***:One hundred and two patients with prediabetes were divided into a manipulation group and a control group according to the random number table method,with 51 cases in each *** patients received the general behavioral intervention for prediabetes,with additional Song-Relaxing and Zhen-Vibrating abdomen manipulation in the manipulation group and oral metformin hydrochloride tablets in the control *** groups received the intervention for six ***:Fourteen patients dropped out during the treatment,and a total of 88 patients completed the trial,including 45 cases in the manipulation group and 43 cases in the control *** the treatment,the prediabetes control rate was 93.3%in the manipulation group and 74.4%in the control group,and the difference between the two groups was statistically significant(P<0.05);no patient in the manipulation group progressed to diabetes,while the rate of conversion to diabetes in the control group was 6.9%,with a significant difference between the two groups(P<0.05).After the treatment,the body mass index(BMI),glycosylated hemoglobin A1c(HbA1c),fasting plasma glucose(FPG),2-hour postload plasma glucose(2hPG)level during an oral glucose tolerance test(OGTT),fasting insulin(FINS),homeostasis model assessment-2 of insulin resistance(HOMA2-IR),total cholesterol(TC),and triglycerides(TG)decreased in both groups versus baseline,with significant differences within the groups;the levels of all indicators were lower in the manipulation group than in the control group(P<0.05),and the differences between the two groups were more prominent at the sixth month(P<0.01).At the sixth month,the high-density lipoprotein cholesterol(HDL-C)in the manipulation group was increased,while there was no significant change in the control *** the co

关键词： Tuina Massage manual therapies Zhen-Vibrating Manipulation Prediabetic State Blood Glucose Lipid Metabolism Insulin Resistance

Protocol-optimizing study of combining Tuina and horse-riding squat exercise for knee osteoarthritis

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Journal of Acupuncture and Tuina Science 2022年第2期20卷 139-151页

作者： XING Hua SHEN Jiayun GONG Li LI Jianhua SHAO Sheng CHU Yuzhou HE Pengfei CHEN Hao KANG Zhiran DAI Dacheng Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai200437China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai200071China

Objective To evaluate the efficacy of Tuina(Chinese therapeutic massage)manipulation plus horse-riding squat exercise in treating knee osteoarthritis(KOA)and optimize the combining *** Based on a 2×2 factorial design,120 eligible KOA patients were randomized into a manipulation group(group A1B2),a manipulation plus horse-riding squat group(group A1B1),a sitting knee-adjustment group(group A2B2 group),and a sitting knee-adjustment plus horse-riding squat group(group A2B1),with 30 cases in each *** intervention was conducted three times a week,lasting for four *** Western Ontario and McMaster Universities osteoarthritis index(WOMAC)was taken as the major measure for efficacy evaluation(including three component scores,pain,stiffness,and daily function,and total score).Results The three component scores(pain,stiffness,and daily function)and the total score of WOMAC showed significant differences after the intervention in the four groups(P0.05).The extensor peak torque at 180°/s changed significantly in group A1B2 after treatment(P0.05).The main effect of manipulation showed significant in affecting the WOMAC pain and total scores(P<0.05).The main effect of horse-riding squat exercise showed significant in affecting the WOMAC pain and stiffness sco

关键词： Tuina Massage manual therapies Physical and Breathing Exercises Horse-riding Squat Exercise Osteoarthritis,Knee Factorial Design

Clinical observation of acupuncture combined with sitting-position knee-adjustment manipulations for patellofemoral arthritis

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Journal of Acupuncture and Tuina Science 2022年第6期20卷 476-481页

作者： ZHANG Kaiyong LIU Peng XU Siwei ZHANG Bimeng ZHAN Hongsheng HONG Jue SHI's Center of Orthopedics and Traumatology Shuguang HospitalShanghai University of Traditional Chinese Medicine Shanghai 201203China Institute of Traumatology&Orthopedics Shanghai Academy of Traditional Chinese MedicineShanghai 201203China ZHAN Hongsheng Shanghai Famous Traditional Chinese Medicine Experience Research Studio Shanghai 201203China Shanghai General Hospital Shanghai 200080China 不详

Objective To observe the efficacy of acupuncture combined with sitting-position knee-adjustment manipulations in treating patellofemoral *** Ninety-two patients with patellofemoral osteoarthritis were randomized into an observation group and a medication group,with 46 cases in each *** observation group received acupuncture and sitting-position knee-adjustment manipulations,and the medication group received oral celecoxib *** 8-week treatment,changes in the short-form McGill pain questionnaire(SF-MPQ)and Lysholm knee scoring scale(LKSS)scores were observed,and the clinical efficacy was *** The total effective rate was 87.0%in the observation group and 63.0%in the control group;the between-group difference was statistically *** treatment,there were no significant differences in the SF-MPQ score or LKSS score(P>0.05).After 8-week treatment,the SF-MPQ[including pain rating index(PRI),visual analog scale(VAS),and present pain intensity(PPI)]and LKSS scores showed notable changes in both groups(P<0.05);the SF-MPQ and LKSS scores in the observation group were significantly different from those in the control group(P<0.05).Conclusion Combining acupuncture and sitting-position knee-adjustment manipulations can reduce pain and ameliorate joint function in patients with patellofemoral osteoarthritis,producing more significant efficacy than oral celecoxib capsules.

关键词： Acupuncture Therapy manual therapies Tuina:Massage Pain Measurement Visual Analog Scale Osteoarthritis,Knee Patellofemoral Osteoarthritis

Effects of Tuina on serum creatine kinase and skeletal muscle mitochondria in delayed onset muscle soreness model rats

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Journal of Acupuncture and Tuina Science 2022年第6期20卷 446-452页

作者： WEI Qingbo ZHAO Qian GU Jialing LIN Jia ZHU Yan SONG Ziqi LI Fenglei YANG Yanping Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Second Chinese Medicine Hospital Nanjing 210017China Jiangsu Haibin Rehabilitation Hospital Lianyungang 222042China 不详

Objective To observe the effect of Tuina(Chinese therapeutic massage)on creatine kinase(CK),mitochondrial Ca^(2+)concentration,and ultrastructure of skeletal muscle in delayed onset muscle soreness(DOMS)model *** A total of 130 healthy male Sprague-Dawley rats were randomly divided into a blank group,an exercise control group,a pre-exercise Tuina group,and a post-exercise Tuina *** to the time points for sample collection,the exercise control group was divided into a 0 h exercise control group,a 24 h exercise control group,a 48 h exercise control group,and a 72 h exercise control group;the pre-exercise Tuina group was further divided into a 0 h pre-exercise Tuina group,a 24 h pre-exercise Tuina group,a 48 h pre-exercise Tuina group,and a 72 h pre-exercise Tuina group;and the post-exercise Tuina group was divided into a 0 h post-exercise Tuina group,a 24 h post-exercise Tuina group,a 48 h post-exercise Tuina group,and a 72 h post-exercise Tuina *** in all groups except for the blank group received DOMS *** performed Nie-Pinching manipulation and finger Nian-Twisting manipulation on the lower limbs of the *** samples were collected at 0 h,24 h,48 h,or 72 h after exhaustive exercise for each pre-exercise Tuina *** samples were collected at 0 h,24 h,48 h,or 72 h after Tuina for each post-exercise Tuina *** changes in serum CK,skeletal muscle mitochondrial Ca^(2+)concentration,and Ca^(2+)-adenosine triphosphatase(ATPase)were *** ultrastructure changes of skeletal muscles in each group were observed by a transmission electron *** The electron microscope showed that compared with the exercise control group,the skeletal muscle structures of the pre-exercise Tuina group and the post-exercise Tuina group were significantly improved,and the overall performance of skeletal muscle in the pre-exercise Tuina group was more similar to that of the blank *** level of serum CK in the pre-ex

关键词： Tuina Massage manual therapies Creatine Kinase Myalgia Fatigue Mitochondria Rats

Effects of sinew-regulating bone-setting manipulations on chondrocytes,IL-1βand NO in rabbits with knee osteoarthritis

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Journal of Acupuncture and Tuina Science 2021年第6期19卷 403-410页

作者： Yao Meng-li Chen Zhao-hui Chen Xiang-hua Xu Han Wang Ting-ting Hu Rong-ting Jin Xiang-yu Jin Han Clinical College of Anhui Medical University Hefei230012China College of Acupuncture-moxibustion and Tuina Anhui University of Chinese MedicineHefei230038China Graduate School Anhui University of Chinese MedicineHefei230038China

Objective To observe the therapeutic effect of sinew-regulating bone-setting manipulations for knee osteoarthritis(KOA)model rabbits and its impacts on the chondrocyte apoptosis rate and the levels of interleukin(IL)-1βand nitric oxide(NO).Methods According to the random number table method,30 New Zealand white rabbits were divided into a normal group(n=9)and a modeling group(n=21).Rabbits in the modeling group were used to establish KOA models with the modified Hulth *** the 8th week,three rabbits were sacrificed to verify the model and the remaining 18 rabbits were randomly divided into a model group(n=9)and an intervention group(n=9).Rabbits in the normal group and model group were bred routinely without any *** in the intervention group were treated with the sinew-regulating bone-setting manipulations,10 min/time,once every other day for a total of 20 *** Lequesne MG knee function rating was used to evaluate the behavioral differences of the rabbits in each *** Pelletier score was used to evaluate the general changes of the *** Mankin score was used to evaluate the pathology of knee *** enzyme-linked immunosorbent assay and nitrate reductase methods were used to determine the levels of IL-1βand NO in serum and synovial fluid of each group,*** situ terminal deoxynucleotidyl transferase-mediated nick and labeling method was used to determine the apoptosis of chondrocytes in each *** Compared with the normal group,the scores of Lequesne MG,Pelletier and Mankin,and the levels of IL-1βand NO in the model group were increased(P<0.05),which indirectly indicated the success of the *** with the model group,the scores of Lequesne MG,Pelletier and Mankin,IL-1βand NO levels,and chondrocyte apoptosis rate of the intervention group were decreased,and the differences were statistically significant(P<0.05).Conclusion The sinew-regulating bone-setting manipulations can reduce the levels of IL-

关键词： Tuina Massage manual therapies Nitric Oxide Interleukin-1 Apoptosis Osteoarthritis,Knee Rabbit

Research on clinical application of manual therapy to tumor-related adverse reactions

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Journal of Acupuncture and Tuina Science 2022年第4期20卷 321-328页

作者： YAO Chongjie LU Zhizhen ZHANG Shuaipan KONG Lingjun ZHU Qingguang CHENG Yanbin FANG Min ZHANG Kaiwei Yueyang Hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Tuina Shanghai Academy of Traditional Chinese MedicineShanghai 200437China College of Acupuncture-moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China 不详

Objective To analyze the clinical application of manual therapy(MT)to tumor-related adverse reactions via summarizing the research at home and abroad,in order to provide more theoretical evidence for the clinical promotion of *** We searched 7 Chinese and English databases,including China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed,Excerpta Medica Database(EMBASE),Ovid and *** publication date was between the establishment date of the database and December 31,*** screened the literature according to the inclusion and exclusion criteria,and then sorted and analyzed the selected *** A total of 46 papers were *** studies focused on the adverse reactions in breast cancer *** interventions demonstrated the best efficacy for fatigue,followed by pain,depression and *** different MT interventions,Tuina(Chinese therapeutic massage)was mainly adopted for fatigue,pain,anxiety,depression,and limb *** pressing was mainly adopted for gastrointestinal and psychological problems such as abdominal bloating,insomnia,depression and *** application of reflexotherapy was similar to that of *** MT can alleviate various adverse reactions by effectively relieving patients’somatic symptoms and improving their psychological states and overall *** can be popularized as a significant non-drug ***,however,the clinical application of MT is neither extensive nor has sufficient basic ***,we should attach importance to this application.

关键词： manual therapies Tuina Massage Acupoint Pressure Therapy Reflexotherapy Tumor Adverse Reaction Literature

Therapeutic efficacy observation of warm needling moxibustion plus spine subtle adjusting manipulation for cervical radiculopathy

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Journal of Acupuncture and Tuina Science 2021年第6期19卷 457-461页

作者： Pan Guo-liang Zeng Liang Dong Xiao-wei Shanghai Pudong Hospital(Fudan University Pudong Medical Center) Shanghai 201399China

Objective To observe the clinical efficacy of warm needling moxibustion plus spine subtle adjusting manipulation for cervical *** A total of 70 patients with cervical radiculopathy were randomized into an observation group and a control group,with 35 cases in each *** observation group was treated with warm needling moxibustion plus spine subtle adjusting manipulation,while the control group was treated with warm needling moxibustion *** treatments were performed three times a week,and for four weeks in *** visual analog scale(VAS)was scored before and after *** the clinical efficacy of the two groups was compared after *** The total effective rate was 97.1%in the observation group,versus 88.6%in the control *** difference between the two groups was statistically significant(P<0.05).After treatment,the VAS scores in both groups significantly decreased(P<0.01),and the score in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Warm needling moxibustion plus spine subtle adjusting manipulation has a better effect in the treatment of cervical radiculopathy than warm needling moxibustion alone.

关键词： Acupuncture Therapy Warm Needling Moxibustion manual therapies Tuina Massage Neck Pain Radiculopathy Cervical Spondylosis