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Convenient One Pot Synthesis and Antibacterial Evaluation of Some New mannich bases Carrying 1,2,4-Triazolyl Moiety

Chinese Journal of Chemistry 2011年第8期29卷 1661-1668页

作者： Arafa, Wael A. A Mohamed, Asmaa S Department of Chemistry Faculty of Science Fayoum University Fayoum Egypt Department of Medical Chemistry Theodor Bilharz Research Institute Egypt

A series of mannich bases were synthesized by a three-component mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential antibacterial effects of the synthesized compounds were investigated using standard bacterial strains： Gram-positive and Gram-negative bacteria. Interestingly, all the synthesized compounds were observed to be promising leads, possessing moderate to significant inhibitory activity as compared to standard.

关键词： bi- 1,2,4-triazoles Schiff bases mannich bases regioselectivity antibacterial activity

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Synthesis and Biological Activities of Some mannich bases of 5-(4-Hydroxyphenyl)-1,3,4-Oxadiazole-2-Thione

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Journal of Chinese Pharmaceutical Sciences 1998年第2期7卷 54-55页

作者：庞华张君仁帅翔王建河山东医科大学药学系

以对羟基苯甲酸乙酯为原料，经肼解、环化合成５（４羟基苯基）１，３，４二唑２硫酮，继而经Ｍａｎｎｉｃｈ反应合成了四种新曼尼希碱，其结构经红外光谱、核磁共振和元素分析证实。初步抑菌活性试验表明，显示弱的抑菌... 详细信息

以对羟基苯甲酸乙酯为原料，经肼解、环化合成５（４羟基苯基）１，３，４二唑２硫酮，继而经Ｍａｎｎｉｃｈ反应合成了四种新曼尼希碱，其结构经红外光谱、核磁共振和元素分析证实。初步抑菌活性试验表明，显示弱的抑菌活性。

关键词： 1,3,4-Oxadiazole-2-thione mannich bases Biological activities

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COMBINATORIAL SYNTHESIS OF mannich bases IN SOLUTION/POLYMER REAGENT WORKUP

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Chinese Journal of Reactive Polymers 2000年第2期9卷 169-173页

作者： HUANG Wenqiang CHENG Shaoling CHEN Yu SUN Weimin HE Binglin Institute of Polymer Chemistry Nankai University Tianjin 300071 China

This paper describes a combinatorial Synthesis of the mannich bases in Solution through the mannich reaction using 3 ketones, 5 amines and formaldehyde in solution and hydrochloride as a catalyst and then using a macroporous quarterized ammonium resin (CO32- form) as a scavenge agent to remove the acid catalyst when the mannich reaction is completed. It was found by GC/MS analysis that the symmetrical ketone, such as acetone, in the mannich reaction mainly produces one mannich base; while the asymmetrical ketone, such as 2-pentanone, gives two mannich bases. The reactivity depends on the tereo-hinder of both ketones and amines.

关键词： Combinatorial Synthesis in Solution mannich reaction mannich bases macroporous quarterized ammonium resin Scavenge Resin$

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Synthesis and Antidiabetic Activity of mannich bases Bearing Different Bioactive Moieties

Synthesis and Antidiabetic Activity of Mannich Bases Bearing...

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大环化学和超分子化学的新发展——当前学科交叉的一个重要桥梁——中国化学会全国第十五届大环化学暨第七届超分子化学学术讨论会

作者： ZHANG Kun~1 YAN Ju-Fang~2 XU Jin~1 SONG Xiao-Li~1 LIU Hong-Ping~1 TANG Xue-Mei~1 ZHANG Ying-Xia~1 ZHOU Zu-Wen~1 YANG Da-Cheng~(*1) (1 School of Chemistry & Chemical Engineering,Southwest University,Chongqing 400715 2 Drug Screening Center,Chengdu Di Ao Pharmaceutical Group Co.Ltd,Chengdu 610041)

mannich bases are important intermediates for organic synthesis,and have attracted a great deal of interests due to their diverse biological activities such as antibacterial,anticancer,antiinflame- mation, antiandroge... 详细信息

关键词： mannich bases diabetes mellitus α-glucosidase PPRE PTP1B

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Corrosion inhibition and thermodynamics of adsorption of mannich bases on mild steel in hydrochloric acid

Corrosion inhibition and thermodynamics of adsorption of Man...

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第十二届全国缓蚀剂学术讨论及应用技术经验交流会

作者： Xin Jian Yuan Wan-zhong School of chemical engineering Dalian University of technology

selected mannich bases,namely phenylaninopropiophenone(PAP) and its p-metonym(p-OCH-PAP),p-methyl(p-CH3-PAP),p-chloro(p-Cl-PAP)derivatives have been synthesized and evaluated as corrosion inhibitions for mild steel in hydrochloric acid(HCl) by means of weight-loss and potentiodynamic polarization *** obtained revealed that all of the compounds studied performed excellently as inhibitors of the corrosion of mild steel in HC1.

关键词： corrosion inhibitor mannich bases Hydrochloric acid statistical model

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Radiation Parameters of Some Potential Bioactive Compounds

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光谱学与光谱分析 2015年第6期35卷 1501-1505页

作者： Zeynep Gedik Mehtap Tugrak Aysenur Dastan Halise Inci Gul Demet Yilmaz Department of Physics Faculty of SciencesAtatürk University Department of Pharmaceutical Chemistry Faculty of PharmacyAtatürk University

In this study,we aimed to determine the radiation parameters of some potential bioactive compounds.1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type mannich bases were synthesized via classical conventional heating *** part was changed as phenyl(C6H5),4-methylphenyl(4-CH3C6H4),4-fluorophenyl(4-FC6H4),4-nitrophenyl(4-NO2C6H4),4-chlorophenyl(4-ClC6H4),4-bromophenyl(4-BrC6H4),and 2-thienyl(C4H3S-2-yl).Mass attenuation coefficient(μm),effective atomic number(Zeff)and effective electron density(Nel)of compounds were determined experimentally and theoretically for at 8.040,8.910,13.40,14.96,17.48,19.61,22.16,24.94,32.19,36.38,44.48,50.38and 59.54keV photon energies by using an HPGe detector with a resolution of 182eV at *** parameters of these compounds which can be anti-cancer drug candidate were given in the *** results show that phenyl ring behave like thiophene ring in terms of radiation *** is thought that the results of study may drive allow the development of drug candidate new compounds in medical oncology.

关键词： Mass attenuation coefficient Effective atomic number Effective electron density mannich bases Anti-cancer drug

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