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Effect of chiropractic manipulation on disrupted epithelium barrier and its mechanism of specialized pro-resolving mediators in a spleen-deficiency murine model

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Journal of Traditional Chinese Medicine 2019年第5期39卷 678-684页

作者： Xiong Ying Song Zhixiu Gu Yun Qin Yuhang Wei Jiangfei Lu Jinlu Zhu Y Teaching and Research Section of Tuina the Second Clinical Medical CollegeNanjing University of Chinese Medicine Nanjing 210023China Teaching and Research Section of Nutrition the Second Clinical Medical CollegeNanjing University of Chinese MedicineNanjing 210023China Laboratory of Acupuncture and Medicine Research of Ministry of Education the Second Clinical Medical CollegeNanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalanc

关键词： manipulation, chiropractic Th1-Th2 balance Epithelial barrier Specialized pro-resolving mediators Spleen deficiency

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An approach to error elimination for multi-axis CNC machining and robot manipulation

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Science China(Technological Sciences) 2007年第5期50卷 560-574页

作者： XIONG CaiHua School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

The geometrical accuracy of a machined feature on a workpiece during machining processes is mainly affected by the kinematic chain errors of multi-axis CNC ma- chines and robots, locating precision of fixtures, and datum errors on the work- piece. It is necessary to find a way to minimize the feature errors on the workpiece. In this paper, the kinematic chain errors are transformed into the displacements of the workpiece. The relationship between the kinematic chain errors and the dis- placements of the position and orientation of the workpiece is developed. A map- ping model between the displacements of workpieces and the datum errors, and adjustments of fixtures is established. The suitable sets of unit basis twists for each of the commonly encountered types of feature and the corresponding locating di- rections are analyzed, and an error elimination (EE) method of the machined feature is formulated. A case study is given to verify the EE method.

关键词： error elimination, multi-axis machine, robot manipulation, kinematic chain, twist

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