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Effect of Manipulation on cartilage in rats with knee osteoarthritis based on the Rho-associated protein kinase/LIM kinase 1/Cofilin signaling pathways

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Journal of Traditional Chinese Medicine 2022年第2期42卷 194-199页

作者： GUO Xiao YANG Yunhao LIAO Dongmei PANG Fang YANG Zhixue ZHU Zhengwei LUO Ao TANG Chenglin College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beibei Traditional Chinese Medicine Hospital Chongqing 400700China

OBJECTIVE:To investigate the effect of Manipulation treatment on knee osteoarthritis rats and the effect on Rho-associated protein kinase(ROCK)/LIM-kinase1(LIMK1)/Cofilin signaling pathway.METHOD:Fifty Specific pathogen Free Sprague-Dawley rats were randomly divided into five groups(n=8 each):blank group,model group,Manipulation group,celecoxib group,and Manipulation combined with celecoxib group(MC group).The osteoarthritis model was established by injecting 0.2 m L 4%papain into the articular disc of the rats.After successfully establishing the model,we treated the Manipulation group with pushing Manipulation using one-finger-meditation to the Neixiyan(EX-LE4),Waixiyan(EX-LE5),Xuehai(SP10),Liangqiu(ST34),and Zusanli(ST36)acupoints for 10 min each time.Also,the celecoxib group was gavaged with 24 mg·kg^(-1)·d^(-1 )celecoxib,while the MC group was treated using both of these two methods.After four weeks,the cartilage of the right femur was removed for hematoxylin-eosin staining of the cartilage tissue.The expressions of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in serum were observed using the enzyme-linked immunosorbent assay.Besides,we detected the expressions of ROCK,LIMK1,Phospho-LIM-kinase1(Phospho-LIMK1),Cofilin,and Phospho-Cofilin by Western blot.RESULTS:Compared to the model group,the Manipulation group,celecoxib group,and MC group all exhibited superior results concerning pathological morphologic changes of cartilage,as observed by hematoxylin-eosin staining and calculated using the Mankin score.Besides,in contrast to the blank group,the model group exhibited elevated serum levels of IL-1βand TNF-α(PManipulation group and the MC group(P<0.01).Compared with t

关键词： osteoarthritis knee Manipulation cytoskeletal proteins Rho-associated kinases LIM kinases actin depolymerizing factors signal transduction

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Manipulation of topological spin textures in centrosymmetric rare-earth magnets

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Journal of Materials Science & Technology 2023年第25期156卷 254-260页

作者： Shulan Zuo Kaiming Qiao Ying Zhang Tongyun Zhao Chengbao Jiang Baogen Shen Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China Ningbo Institute of Materials Technology & Engineering Chinese Academy of SciencesNingbo 315201China

Topologically protected magnetic skyrmions are expected to be used in the next-generation spintronic devices.Realizing their nucleation and Manipulation at room temperature is fundamental for future practical applications.Here,using in situ Lorentz transmission electron microscopy and micromagnetic simulation,we demonstrate that magnetic biskyrmions can spontaneously exist at room temperature in Nd_(1-x) Tb_(x)Co_(5)(x=0.3,0.5)alloys.The spontaneous biskyrmions are controllably obtained over a wide temperature range across room temperature by switching atomic chemical environment.Furthermore,the density of biskyrmions can be tuned by a small magnetic field.High-density biskyrmions are stimulated to form in the thinner region at room temperature by introducing an in-plane magnetic field component.These results provide valuable insights into the Manipulation of topological states,which is of great significance to their practical applications.

关键词： Biskyrmions Spin-reorientation transition Manipulation Nd1–TbCo5

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Giant 2D Skyrmion Topological Hall Effect with Ultrawide Temperature Window and Low-Current Manipulation in 2D Room-Temperature Ferromagnetic Crystals

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Chinese Physics Letters 2023年第11期40卷 131-138页

作者：张高节罗清源文晓琨武浩杨丽靳雯李路吉张佳张文峰舒海波常海欣 State Key Laboratory of Material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Wuhan National High Magnetic Field Center and Institute for Quantum Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China Shenzhen R&D Center of Huazhong University of Science and Technology Shenzhen 518000China

The discovery and Manipulation of topological Hall effect(THE),an abnormal magnetoelectric response mostly related to the Dzyaloshinskii–Moriya interaction(DMI),are promising for next-generation spintronic devices based on topological spin textures such as magnetic skyrmions.However,most skyrmions and THE are stabilized in a narrow temperature window either below or over room temperature with high critical current Manipulation.It is still elusive and challenging to achieve large THE with both wide temperature window till room temperature and low critical current Manipulation.Here,using controllable,naturally oxidized sub-20 and sub-10 nm 2D van der Waals room-temperature ferromagnetic Fe_(3)GaTe_(2-x)crystals,we report robust 2D skyrmion THE with ultrawide temperature window ranging in three orders of magnitude from 2 to 300 K,in combination with giant THE of~5.4μΩ·cm at 10 K and~0.15μΩ·cm at 300 K,which is 1–3 orders of magnitude larger than that of all known room-temperature 2D skyrmion systems.Moreover,room-temperature current-controlled THE is also realized with a low critical current density of~6.2×10^(5)A·cm^(-2).First-principles calculations unveil natural oxidation-induced highly enhanced 2D interfacial DMI reasonable for robust giant THE.This work paves the way to room-temperature electrically controlled 2D THE-based practical spintronic devices.

关键词： topological Manipulation magnetic

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Recent progress on optomagnetic coupling and optical Manipulation based on cavity-optomagnonics

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Frontiers of physics 2022年第4期17卷 115-133页

作者： Kai Wang Yong-Pan Gao Rongzhen Jiao Chuan Wang School of Science and the State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering and the State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Artificial Intelligence Beijing Normal UniversityBeijing 100875China

Recently,the photon–magnon coherent interaction based on the collective spins excitation in ferromagnetic materials has been achieved experimentally.Under the prospect,the magnons are proposed to store and process quantum information.Meanwhile,cavity-optomagnonics which describes the interaction between photons and magnons has been developing rapidly as an interesting topic of the cavity quantum electrodynamics.Here in this short review,we mainly introduce the recent theoretical and experimental progress in the field of optomagnetic coupling and optical Manipulation based on cavity-optomagnonics.According to the frequency range of the electromagnetic field,cavity optomagnonics can be divided into microwave cavity optomagnonics and optical cavity optomagnonics,due to the different dynamics of the photon–magnon interaction.As the interaction between the electromagnetic field and the magnetic materials is enhanced in the cavity-optomagnonic system,it provides great significance to explore the nonlinear characteristics and quantum properties for different magnetic systems.More importantly,the electromagnetic response of optomagnonics covers the frequency range from gigahertz to terahertz which provides a broad frequency platform for the multi-mode controlling in quantum systems.

关键词： optomagnetic coupling Manipulation cavity-optomagnonics photon–magnon interaction

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Effect of spinal Manipulation on degenerative scoliosis

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Journal of Traditional Chinese Medicine 2020年第6期40卷 1033-1040页

作者： Sun Wu Gao Jinghua Zhu Liguo Wang Baojian Xiao Wei Wang Zhenzhong Yang Kexin Spine Department 2 Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing 100102China State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine Jiangsu Kanion Pharmaceutical Co.Ltdv Lianyungang 222001Jiangsu ProvinceChina

OBJECTIVE:To investigate the effect of spinal Manipulation(SM)on degenerative scoliosis by evaluating patients’visual analog scale(VAS)scores,Cobb angles,sagittal vertical axis(SVA),and apical vertebral rotation(AVR)and to explore factors that influence treatment effect.METHODS:A total of 55 patients with degenerative scoliosis received 4 weeks of SM.After treatment,patients were divided into two groups:the remission group(VAS score<40 mm)and the non-remission group(VAS score≥40 mm).Pre-versus post-treatment VAS scores,Cobb angles,SVA,and AVR were compared in each group and in the total population.Baseline data(sex,age,symptom characteristics,duration of symptoms,VAS score,Cobb angle,SVA,and AVR)were compared between groups.Factors influencing the post-treatment VAS score were explored with multiple linear regression analysis.RESULTS:No changes were found in the Cobb angle(P=0.722)or AVR(P=0.424)after intervention in the overall population.However,the SVA(P<0.001)and VAS score(P=0.000)changed significantly after treatment.Similar changes were observed in the remission group(n=29).Multiple linear regression revealed that the only factors influencing treatment effect were symptom characteristics,SVA,and VAS score.CONCLUSION:SM relieved pain and improved sagittal imbalance in patients with degenerative scoliosis.It did not lessen the severity of coronal curvature or vertebral rotation.Factors influencing the effect of SM included symptom characteristics,VAS score,and SVA.A larger randomized trial is needed to further confirm our results.

关键词： Manipulation spinal Scoliosis Cobb angle Sagittal vertical axis Apical vertebral rotation

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Whitefly adaptation to and Manipulation of plant resistance

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Science China(Life Sciences) 2021年第4期64卷 648-651页

作者： Lilong Pan Hui Du Xintong Ye Xiaowei Wang Minisiry of Agriculure Key Laboraon of Molecular Biology of Crop Pathogens and Insecis Instiute of Inseet SciencesZhejiang UniversityHangzhou 310058China Srate Key Laboralory for Managing Biotic and Chemical Threats 10 the Qnaliy and Sofery of Agroproducts.Insitne of Plant Virology Ningbo UniversinNingbo 315211China

Insect herbivores resemble one of the most significant biotic stresses to plants in natural and agricultural ecosystems,due to their high diversity and abundance(Wu and Baldwin,2010).In the long-term coexistence between plants and insect herbivores,plants have evolved a diverse array of defense machineries to fend off attacks from insect herbivores.

关键词： ecosystems resistance Manipulation

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Cofactor Manipulation to drive biosynthesis of natural products

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Synthetic and Systems Biotechnology 2022年第4期7卷 1073-1074页

作者： Qidou Gao Mengyao Zhang Xiaobing Yang College of Enology Northwest A&F UniversityYanglingShaanxi712100China

Microbial production of value-added products is a promising alternative to plant-and chemical-based routes[1].However,only few of interested chemicals are producing at bulk scale with microbial cell factories(eg.artemisinic acid)while most are staying at bench level.To enable the microbes toward efficient bioproduction,extensive endeavors have been expended on enzyme exploration and pathway decoration,leaving the role of cofactors,especially the rare cofactors like SAM,FMN(H_(2))and FAD(H_(2)),largely unconsidered[2,3].

关键词： enable Manipulation interested

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In-hand Manipulation of a circular dynamic object by soft fingertips without angle measurement

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Science China(Information Sciences) 2021年第5期64卷 193-208页

作者： R.GARCIA-RODRIGUEZ V.PARRA-VEGA Aeronautical Engineering Program and Postgraduate Program in Aerospacial Engineering Universidad Politecnica Metropolitana de Hidalgo Robotics and Advanced Manufacturing Department Research Center for Advanced Studies (CINVESTAV)

A multi-fingered robotic hand with curved fingertips enables contact re-positioning without reattaching at the expense of fingertip rolling. This rolling stands for a characteristic that facilitates dexterous Manipulation but results in an algebraically complex dynamic model subject to such constraints. The hemispherical shape of fingertips allows a dexterous Manipulation when controlling the tangent forces, which are essential to rotate object. However, the measurement of the object angle in practice requires tactile-optical sensing. In this paper, considering robotic fingers with curved soft tips, we propose a feedback control that ensures optimal dynamical grasping of a circular rigid object. It is shown that the collaboration of the contact forces, to get a minimum pose of internal forces, and the tangential forces, to induce the conditions for assuring the grasp closure, is necessary to get a skillful Manipulation. In this case, the orientation control of a circular object to the desired angle while avoiding direct measurement of the object angle is presented. Stability conditions of the system are presented in the sense of stability-in-the-manifold. Finally, representative simulations are shown and discussed.

关键词： optimal grasping Manipulation soft-fingertips circular object stability-in-the-manifold

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Learning synergies based in-hand Manipulation with reward shaping

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 141-149页

作者： Zhen Deng Jian Wei Zhang TAMS Group InformaticsUniversity of HamburgHamburg D-22527Germany

In-hand Manipulation is a fundamental ability for multi-fingered robotic hands that interact with their environments.Owing to the high dimensionality of robotic hands and intermittent contact dynamics,effectively programming a robotic hand for in-hand Manipulations is still a challenging problem.To address this challenge,this work employs deep reinforcement learning(DRL)algorithm to learn in-hand Manipulations for multi-fingered robotic hands.A reward-shaping method is proposed to assist the learning of in-hand Manipulation.The synergy of robotic hand postures is analysed to build a low-dimensional hand posture space.Two additional rewards are designed based on both the analysis of hand synergies and its learning history.The two additional rewards cooperating with an extrinsic reward are used to assist the in-hand Manipulation learning.Three value functions are trained jointly with respect to their reward functions.Then they cooperate to optimise a control policy for in-hand Manipulation.The reward shaping not only improves the exploration efficiency of the DRL algorithm but also provides a way to incorporate domain knowledge.The performance of the proposed learning method is evaluated with object rotation tasks.Experimental results demonstrated that the proposed learning method enables multi-fingered robotic hands to learn in-hand Manipulation effectively.

关键词： Manipulation policy jointly

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Manipulation for degenerative lumbar spondylolisthesis:A systematic review of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 121-127页

作者： Zhiwei Liu Xiaokuan Qin Kai Sun He Yin Xin Chen Bowen Yang Xu Wang Xu Wei Liguo Zhu School of Postgraduate Beijing University of Chinese MedicineBeijing100029China Department of Spine Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing100102China Department of Academic Development Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing100102China

Objective: To assess the effectiveness and safety of Manipulation intervention for degenerative lumbar spondylolisthesis(DLS).Methods: This is a systematic review and meta-analysis. A full-scale retrieval method was performed until February 1, 2021, including nine databases. The homogeneity of different studies was summarized using the Review Manager. The quality of studies was determined with the Cochrane risk-of-bias tool.The evidence quality was graded with the Grading of Recommendations, Assessment, Development, and Evaluations approach.Results: A total of 6 studies involving 524 participants were included. The review demonstrated that Manipulation has statistically significant improvements for treating DLS according to Japanese Orthopedic Association scores(mean difference, 3.76;95% confidence interval, 2.63 to 4.90;P Manipulation and traction group was statistically significant(P Manipulation treatment can significantly improve the lumbar spine rotation angle on X-ray images compared with the baseline data(P Manipulation group(experimental group) had fewer adverse events than the lumbar traction group(control group).Conclusion: Manipulation intervention is more effective and safer for DLS. Nevertheless, large-scale randomized controlled trials are required to confirm the current conclusions.

关键词： Manipulation Degenerative lumbar spondylolisthesis Meta-analysis Japanese orthopedic association Oswestry disability index Visual analog scale Randomized controlled trial

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