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Effect of mangosteen(Garcinia mangostana Linn)peel extract on migration of endothelial cells treated with lipopolysaccharide

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中国药理学与毒理学杂志 2015年第S1期29卷 65-65页

作者： DianNUGRAHENNY NurPERMATASARI AdiantoJAYANAGARA TitinAndriWIHASTUTI DjangganSARGOWO Department of Pharmacology Internal Medicine Department Faculty of Medicine Universitas Brawijaya Medical Program Internal Medicine Department Faculty of Medicine Universitas Brawijaya Nursing Program Internal Medicine Department Faculty of Medicine Universitas Brawijaya Division of Cardiovascular Internal Medicine Department Faculty of Medicine Universitas Brawijaya Matang 65145 Indonesia

OBJECTIVE This study was aimed to evaluate the effect of mangosteen peel extract(MPE)on migration of human umbilical vein endothelial cells(HUVECs)treated with *** Cultured HUVECs were divided into five groups:normal(untreated)group,positive control group treated with LPS at dose of 20ng·mL-1 for 24 h,and groups pre-treated with LPS at dose of 20ng·mL-1 for 24 h followed by incubation with MPE at doses of 1,2,and 4-1μg·mL,*** migration was evaluated using wound-healing migration assay after 24 h of *** LPS significantly(Pmangosteen peel extract is able to dose-dependently preserve the endothelial cells function.

关键词： mangosteen peel extract migration endothelial cell

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Biofilm analyses and exoproduct release by clinical and environmental isolates of Burkholderia pseudomallei from Brazil

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 321-328页

作者： Glaucia Morgana de Melo Guedes Crister JoséOcadaque Alyne Soares Freitas Rodrigo Machado Pinheiro Giovanna Barbosa Riello Silviane Praciano Bandeira Rossana de Aguiar Cordeiro Marcos Fábio Gadelha Rocha JoséJúlio Costa Sidrim Débora de Souza Collares Maia Castelo-Branco Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologyGroup of Applied Medical MicrobiologyFederal University of CearáFortalezaCEBrazil Department of Clinical and Toxicological Analysis School of PharmacyFederal University of CearáFortalezaCEBrazil Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologyLaboratory of Emerging and Reemerging PathogensFederal University of CearáFortalezaCEBrazil School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of CearáFortalezaCEBrazil

Objective:To characterize biofilm production by clinical(n=21)and environmental(n=11)isolates of Burkholderia pseudomallei and evaluate the production of proteases,hemolysins and ***:Initially,the 32 strains were evaluated for biofilm production in Müller-Hinton broth-1%glucose(MH-1%glucose)and BHI broth-1%glucose,using the crystal violet staining ***,growing(48 h)and mature(72 h)biofilms were evaluated by confocal ***,the production of proteases,hemolysins and siderophores by planktonic aggregates,growing biofilms and mature biofilms was ***:All isolates produced biofilms,but clinical isolates had significantly higher biomass in both MH-1%glucose(P<0.001)and BHI-glucose 1%(P=0.005).The structural analyses by confocal microscopy showed thick biofilms,composed of multiple layers of cells,homogeneously arranged,with mature biofilms of clinical isolates presenting higher biomass(P=0.019)and thickness of the entire area(P=0.029),and lower roughness coefficient(P=0.007)than those of environmental *** production by growing biofilms was significantly greater than that of planktonic(P<0.001)and mature biofilms(P<0.001).Hemolysin release by planktonic aggregates was higher than that of biofilms(P<0.001).Regarding siderophores,mature biofilms presented higher production than growing biofilms(P<0.001)and planktonic aggregates(P<0.001).Conclusions:Clinical isolates have higher production of biofilms than their environmental counterparts;protease and siderophores seem important for growth and maintenance of Burkholderia pseudomallei biofilms.

关键词： mangosteen Burkholderia pseudomallei Biofilms Proteases Hemolysins Siderophores

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Larvicidal activity of the pericarp extract of Garcinia mangostana against dengue vector Aedes aegypti in Sri Lanka

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Asian Pacific Journal of Tropical Medicine 2022年第3期15卷 135-142页

作者： Nayana Gunathilaka Yashoda Wijebandara Deepika Amerasinghe Lahiru Udayanga Thusitha PMuhandiramlage Department of Parasitology Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka Department of Zoology and Environmental Management Faculty of ScienceUniversity of KelaniyaDalugamaSri Lanka Department of Biosystems Engineering Faculty of Agriculture and Plantation ManagementWayamba University of Sri LankaMakaduraSri Lanka Department of Biochemistry and Clinical Chemistry Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka

Objective:To assess the larvicidal activity of mangosteen(Garcinia mangostana)against larval stages of Aedes aegypti ***:A crude extract was prepared in ethanol from powdered mangosteen pericarps.A concentration gradient(0.01-4.92 g/L)was prepared from the stock *** batches of 25 third instar larvae of Aedes aegypti were used for larval *** mortality rates were observed after one and 24 *** and total lipid contents in 20 randomly selected dead larvae at each trial were assessed by colorimetric *** experimental setup was repeated five *** General Linear Model and Probit analysis were used to evaluate the relationship of mortality with cholesterol level,total lipid level and cholesterol to total lipid ***:The percentage mortalities significantly varied with different concentrations(F_(7,32)=385.737;P<0.001).The LC50 and LC99 values were(0.041±0.006)g/L and(10.616±1.758)g/L,respectively after 24 *** was no mortality recorded within the one-hour exposure *** the cholesterol content(F_(5,24)=173.245;P<0.001)in larvae exposed to different concentrations denoted a significantly decreasing trend within 24-hour *** that were exposed to the lowest concentration(0.55 g/L)showed a higher cholesterol level(22.67±1.33)μ***:The Garcinia mangostana extract acts as an effective sterol carrier protein inhibitor that inhibits cholesterol uptake in Aedes aegypti ***,it could be explored for use as a key source for the development of an environment-friendly plant-based larvicide.

关键词： mangosteen Mosquito Larvicide Garcinia mangostana Aedes aegypti

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<i>α</i>-Mangostin Promotes DAF-16-Mediated Thermotolerance in <i>Caenorhabditis elegans</i>

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Food and Nutrition Sciences 2018年第6期9卷 693-702页

作者： Nattapong Thammawong Haruka Takahashi Takaya Sugawara Kazuichi Sakamoto Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan

Garcinia mangostana, commonly known as mangosteen, is a tropical fruit with a reddish-purple pericarp. In Southeast Asia, the pericarp has traditionally been used as a medicine to treat various diseases, including inflammation, wounds, and bacterial infections, as well as aging. α-mangostin is an abundant xanthone in the pericarp, and is thought to play a critical role in the medicinal effects of mangosteens. Previous studies have demonstrated numerous beneficial effects of α-mangostin, such as cytotoxicity in cancer cells. However, the effects of this xanthone in in vivo have not yet been studied. In the current study, C. elegans was used to test the in vivo effects of α-mangostin using several bioassays, including fat accumulation, pharyngeal movement (pumping) and heat-stress assays. Quantitative real time PCR (qRT-PCR) was also used to examine the expression of heat shock proteins. The results revealed that α-mangostin appeared to cause an increase in fat accumulation, which correlated with an increase in pharyngeal movement. The thrashing movement of the worms after heat stress also showed a correlation with an increase in heat shock protein mRNA expression.

关键词： mangosteen α-Mangostin Thermotolerance Caenorhabditis elegans DAF-16

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