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Patients with functional bowel disorder have disaccharidase deficiency:A single-center study from Russia

World Journal of Clinical Cases 2021年第17期9卷 4178-4187页

作者： Saria Dbar Olga Akhmadullina Elena Sabelnikova Nikolai Belostotskiy Asfold Parfenov Svetlana Bykova Sergey Bakharev Elena Baulo Alexandra Babanova Lilia Indeykina Tatyana Kuzmina Tatiana Kosacheva Aleksey Spasenov Alina Makarova Non-inflammatory Bowel Diseases Moscow Health DepartmentMoscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia Moscow Health Department Moscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia Pre-Clinical Research Laboratory Moscow Clinical Scientific Center Named after A.S.Loginov MHDMoscow 111123Russia Department of Bowel Pathology Moscow Health DepartmentMoscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia Laboratory of Functional Diagnostics of Intestinal Diseases Moscow Health DepartmentMoscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia Nutraceuticals Laboratory Moscow Health DepartmentMoscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia Department of Medical Statistics Moscow Health DepartmentMoscow Clinical Scientific Center n.a.A.S.LoginovMoscow 111123Russia

BACKGROUND Functional bowel disorder(FBD)may be caused by a decrease in disaccharidase ***,the timely diagnosis of disaccharidase deficiency could lead to a better prognosis in patients with this *** To determine the potential value of intestinal disaccharidases glucoamylase,maltase,sucrase,and lactase in understanding the etiology and pathogenesis of *** A total of 82 FBD patients were *** to the Rome IV criteria(2016),23 patients had diarrhea-predominant irritable bowel syndrome(IBS),33 had functional diarrhea,10 had constipation-predominant IBS,4 had functional constipation,and 12 had mixed *** Dahlqvist method was used to measure disaccharidase activity in the brush-border membrane of mature enterocytes of the small intestine,in duodenal biopsies obtained during *** Lactase deficiency was detected in 86.5%of patients,maltase deficiency in 48.7%,sucrase deficiency in 50%,and glucoamylase deficiency in 84.1%.The activities of all enzymes were reduced in 31.7%of patients,and carbohydrase deficiency was detected in 63.5%of *** low activity of enzymes involved in membrane digestion in the small intestine was found in 95.2%of *** In 78 of the 82 patients with FBD,gastrointestinal symptoms were associated with disaccharidase deficiency.

关键词： Functional bowel disorder Irritable bowel syndrome Disaccharidase deficiency maltase deficiency Sucrase deficiency Lactase deficiency

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