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malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy:a report and review of literature

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Journal of Otology 2020年第3期15卷 112-116页

作者： K Devaraja Dipak Ranjan Nayak Department of Otorhinolaryngology and Head and Neck Surgery Kasturba Medical CollegeManipal Academy of Higher EducationUdupiKarnataka576104India

Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves *** can it also effect one or more of cranial nerves IX,X,XI,and *** present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial *** patient though later on had internal jugular vein thrombosis,which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis,and later on,to aggravate the *** proper blood sugar control and appropriate long term antibiotics,not only that the patient is disease free at one year follow up,but the cranial nerve deficits also *** from sharing the clinical and management details of this patient,we have reviewed the relevant literature in the discussion,which has shed some light onto some of the interesting facts about this condition and its prognosis.

关键词： Skull base osteomyelitis malignant otitis externa Hypoglossal palsy Diabetes mellitus Internal jugular vein

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Hyperbaric oxygen therapy in malignant otitis externa:A systematic review of the literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 296-302页

作者： Young Jae Byun Jaimin Patel Shaun A.Nguyen Paul R.Lambert Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA University of Central Florida College of Medicine OrlandoFLUSA

Objective:To review the role of adjuvant hyperbaric oxygen therapy(HBOT)in the treatment of malignant otitis externa(MOE).Data sources:PubMed,Scopus,Web of Science,Science Direct,and Cochrane Library were searched for the following concepts:“hyperbaric oxygen”and“malignant or necrotizing otitis externa.”Methods:Studies were included if they contained(1)patients with reported evidence of MOE,(2)employment of adjuvant HBOT,(3)details on patients’medical condition,and(4)documented survival *** information included patient demographics,underlying medical conditions,infectious etiology,signs and symptoms,medical and surgical treatments,duration of medical treatment,mean follow up time,HBOT setting,number of HBOT sessions,complications,survival rate,and all-cause ***:A total of 16 studies comprising 58 patients(mean age 68.0 years)were *** was present in 94.7%of cases and Pseudomonas spp(64.3%)was the most common infectious *** nerve VII was involved in 55.2%of ***,the disease cure rate with adjuvant HBOT was 91.4%and all-cause mortality was 8.6%.Among those who had cranial nerve VII involvement,72.0%had return of function and 93.8%of them ***:HBOT may be an effective treatment option for refractory or advanced MOE but its efficacy remains unproven due to lack of strong scientific ***,its therapeutic value should not be underestimated given good results and few adverse events reported in this study.

关键词： malignant otitis externa Necrotizing otitis externa Diabetes mellitus Hyperbaric oxygen Therapy Osteomyelitis

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The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay K.Gupta Neil C.Molony Keshav K.Gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis skull base osteomyelitis temporal bone osteomyelitis

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Skull Base Osteomyelitis: A Rare Cause of Multiple Cranial Nerve Palsies—A Case Report from Ghana

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World Journal of Neuroscience 2023年第4期13卷 257-265页

作者： Ekins Kuuzie Prince Kwabla Pekyi-Boateng Annie Yennah Fiifi Duodu Department of Surgery St. Dominic Hospital Akwatia Ghana Department of Anesthesiology 37 Military Hospital Accra Ghana Department of Surgery Ho Teaching Hospital Ho Ghana Department of Neurology Korle-Bu Teaching Hospital Accra Ghana

Introduction: Skull Base Osteomyelitis (SBO) is an infectious inflammation of the skull bones that is often caused by malignant otitis externa (MOE) and affects the temporal bone. This condition commonly affects immunocompromised individuals and the elderly, particularly those with a history of diabetes mellitus. Diagnosis is challenging because of non-specific symptoms that lead to late detection and complications. This report discusses a case of SBO with multiple bilateral cranial nerve abnormalities and highlights the diagnostic and management challenges in high-risk individuals with subtle clinical signs. Case presentation: This report describes a 63-year-old patient with hypertension and diabetes who underwent surgical debridement of the left ear due to malignant otitis externa 4 months prior to presentation. The patient presented with significant dysarthria, dysphagia, ptosis of the left eye with double vision, and hearing impairment in the left ear. Examination revealed bilateral CN VI palsy, right CN VII palsy, left CN VIII palsy, and a right CN XII deficit. Initial tests were unremarkable, but a high Fungitell assay and a second review of the CT scan and MRI revealed a pathological process in the base of the skull involving bony structures and cranial nerves bilaterally, which helped diagnose SBO. The patient was subsequently discharged with oral voriconazole and continued his usual medications. The patient requested further management abroad, because he did not notice resolution of his symptoms. Surgical treatment was employed abroad to relieve his symptoms, as he recovered slowly. Conclusion: This case report underscores the importance of a multidisciplinary approach to address SBO. Collaboration between specialists in infectious diseases, otolaryngology, radiology, and neurology plays a pivotal role in achieving an accurate diagnosis and developing a tailored treatment plan. Although SBO may be infrequent, this case report highlights the need to maintain

关键词： Skull Base Osteomyelitis Cranial Nerves malignant otitis externa Bulbar Palsy Fungal Infection

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