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Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis

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Journal of Traditional Chinese Medicine 2017年第1期37卷 30-34页

作者： Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin Traditional Chinese Medicine Department of National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China He Shengqi Lu DianrongWang FangDu YanlinOncology Department of Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone ***: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and ***: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control ***: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction.

关键词： malignant tumor Neoplasm metastasis Alkaline phosphatase Collagen type Ⅰ

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Surgically treated primary malignant tumor of small bowel:A clinical analysis

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World Journal of Gastroenterology 2010年第12期16卷 1527-1532页

作者： Han, Shao-Liang Cheng, Jun Zhou, Hong-Zhong Guo, Sheng-Cong Jia, Zeng-Rong Wang, Peng-Fei Wenzhou Med Coll Affiliated Hosp 1 Dept Gen Surg Wenzhou 325000 Zhejiang Prov Peoples R China

AIM:To evaluate the clinical presentation,treatment and survival of patients with primary malignant tumor of small bowel(PMTSB).METHODS:Clinicopathologic data about 141 surgically treated PMTSB patients(91 males and 50 females) at the median age of 53.5 years(range 23-79 years) were retrospectively ***:The most common initial clinical features of the patients were intermittent abdominal discomfort or vague abdominal pain(67.4%),abdominal mass(31.2%),bowel obstruction(24.1%),hemotochezia(21.3%),jaundice(16.3%),fever(14.2%),coexistence of bowel perforation and peritonitis(5.7%),coexistence of gastrointestinal bleeding and shock(5.0%),and intraabdominal bleeding(1.4%).Ileum was the most common site of tumor(44.7%),followed by jejunum(30.5%)and duodenum(24.8%).PMTSB had a nonspecific clinical *** bowel resection(n=81)was the most common surgical procedure,followed by right hemicolectomy(n=15),pancreaticoduodenectomy(n=10),and others(n=19).Twenty-seven adenocarcinoma patients and 13 malignant lymphoma patients received adjuvant chemotherapy with 5-fluorouracil and cyclophosphamide,adriamycin,vincristine and prednisone,*** about 120 patients was obtained during the *** median survival time of PMTSB patients was 20.3 *** 1-,3-and 5-year survival rate was 75.0%(90/120),40.0%(48/120)and 20.8%(25/120),*** was found in 73.7%(42/57),21.1%(12/57)and 15.8%(9/57)of the patients,*** stromal tumor was observed in 80.0%(20/25),72.0%(18/25)and 36.0%(9/25)of the patients,*** was detected in 100.0%(15/15),80.0%(12/15)and 46.7%(7/15)of the patients,*** lymphoma was demonstrated in 69.2%(9/13),30.8%(4/13)and 0%(0/13)of the patients,***:En bloc resection is the principal therapy for most PMTSB and chemotherapy is the important treatment modality for malignant lymphoma and other malignant tumors of small bowel which ca

关键词： Small bowel malignant tumor Diagnosis Surgical treatment Chemotherapy

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Effect of grain-shaped moxibustion on the expression of IL-12 in peripheral blood in malignant tumor patients with both qi and blood deficiency undergoing chemotherapy

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World Journal of Acupuncture-Moxibustion 2015年第4期25卷 15-19页

作者：许林玲徐天舒南京中医药大学中西医结合鼓楼临床医学院江苏南京210029

Objective To observe the clinical efficacy of grain-shaped moxibustion in reinforcing healthy qi and dispelling pathogen and to explore the possible mechanisms of grain-shaped moxibustion in improving immune function of patients through determining the expression level of IL-12 in peripheral blood of patients. Methods Seventy patients undergoing chemotherapy due to deficiency of both qi and blood type of malignant tumor in the departments of traditional Chinese medicine and oncology in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School from January 2014 to January 2015 were randomly divided into a chemotherapy group（group A） and a chemotherapy combined with grain-shaped moxibustion group（group B） by sortition, 35 cases in each one. Patients in both groups received chemotherapy, while patients in group B also received grain-shaped moxibustionat on bilateral Zúsānl（足三里 ST 36）, which was performed once daily, 7 cones every time, for a total of continuous 20 days. Before and after treatment, the expression level of IL-12 in peripheral blood of patients was determined using ELISA method. Results After chemotherapy, the expression level of IL-12 in patients was significantly lower than that before treatment. After two courses of adjuvant therapy of grain-shaped moxibustion, the expression level of IL-12 in chemotherapy patients slightly increased and the difference was statistically significant（P〈0.05）. Conclusion Grain-shaped moxibustion can increase the expression of IL-12 in peripheral blood of patients, promote the T cellmediated immune response and achieve immunoregulation and anti-tumor effects.

关键词： grain-shaped moxibustion therapy malignant tumor chemotherapy IL-12

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Value of ^(99m)Tc-MDP SPECT/CT fusion imaging and CT in evaluating the extent of mandibular invasion by malignant tumor of oral cavity

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The Chinese-German Journal of Clinical Oncology 2012年第12期11卷 694-698页

作者： Qingyun Duan Muyun Jia Rongtao Yuan Lingxue Bu Wei Shang Xiaoming Jin Ningyi Li Jie Zhao Guoming Wang Department of Oral&Maxillofacial Sugery Hangzhou First People's HospitalHangzhou 310006China Department of Oral&Maxillofacial Sugery The Affiliated Hospital of O.jngdao University Medical CollegeO.jngdao 266003China Pathology Deparment The Affiliated Hospital of Qjngdao University Medical CollegeQjngdao 266003China Nuclear Medicine The Affiliated Hospital of Qingdao University Medical CollegeOjngdao 266003China

Objective： The aim of our study was to compare the value of computed tomography （CT） and 99mTc-methylene- diphosphonate （MDP） SPECT （single photon emission computed tomography）/CT fusion imaging in determining the extent of mandibular invasion by malignant tumor of the oral cavity. Methods： This study had local ethical committee approval, and all patients gave written informed consent. Fifty-three patients were revealed mandibular invasion by malignant tumor of the oral cavity underwent CT and SPECT/CT. The patients were divided into two groups： group A （invasion-periphery-type） and group B （invasion-center- type）. Two radiologists assessed the CT images and two nuclear medicine physicians separately assessed the $PECT/CT images in consensus and without knowledge of the results of other imaging tests. The extent of bone involvement suggested with an imaging modality was compared with pathological findings in the surgical specimen. Results： With pathological findings as the standard of reference, Group A： The extent of mandibular invasion by malignant tumor under- went SPECT/CT was 1.02 _＋ 0.20 cm larger than that underwent pathological findings. And the extent of mandibular invasion underwent CT was 1.42 ＋ 0.35 cm smaller than that underwent pathological examination. There were significant difference among the three methods （P 〈 0.01）. Group B： The extent of mandibular invasion by malignant tumor underwent SPECT/CT was 1.3 ＋ 0.39 cm larger than that underwent pathological examination. The extent of mandibular invasion underwent CT was 2.55 ＋ 1.44 cm smaller than that underwent pathological findings. There were significant difference among the three methods （P 〈 0.01）. The extent of mandibular invasion underwent SPECT/CT was the extent which surgeon must excise to get clear margins. Conclusion： SPECT/CT fusion imaging has significant clinical value in determining the extent of mandibular inva- sion by malignant tumor of oral cavity.

关键词： SPECT/CT fusion imaging mandibular invasion malignant tumor

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Clinical Research on the Changes of Plasma TFPI and uPA System in malignant tumor

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The Chinese-German Journal of Clinical Oncology 2004年第2期3卷 78-80,124页

作者：张爱华李小亮孙达春何志国珠海市人民医院内科 519000

Objective: To investigate the expression levels and significance of TFPI, uPA, uPAR and PAI in malignant patients. Methods: The levels of TFPI, uPA and uPAR were measured by using ELISA and the level of PAI was determined by method of chromogenic substrates in 44 patients with malignant solid tumors (group A1) and 30 patients with acute leukemia (AL, group A2). Results: The levels of TFPI, uPA, and uPAR in group A1 were higher than those in normal control group (group B). TFPI, uPAR levels in group A2 were higher than those in group B, while the level of PAI in group A2 was lower than that in group B. Among the groups, TFPI was increased in the combined infection group; PAI decreased in the hemorrhage group; TFPI, uPA, uPAR and PAI increased in relapsing and metastasis group; TFPI decreased in one-week dead group, while uPA and uPAR increased. Conclusion: The patients with malignant solid tumor and AL had different anticoagulation or fibrinolysis states. TFPI, uPA, Upar and PAI can be used to evaluate the disease condition and the prognosis.

关键词： malignant tumor acute leukemia tissue factor pathway inhibitor urokinase plasminogen

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The study of serum sialic acid clinical significance in malignant tumor

The study of serum sialic acid clinical significance in mali...

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山东生物化学与分子生物学会2009年学术会议

作者： NIU Ai-jun,WANG Kai-sen,XUE Lian,HU Cheng-jin. General Hospital of Jinan Military Region,jinan,250031

＜正＞Objective To study the diagnosis valve and clinical significance of serum sialic acid in malignant *** Using enzymic method,we detected the serum sialic acid levels in 50 healthy persons,90 benign disease patients,160 malignant tumor patients,and analyzed the serum sialic acid levels change in different pathological types and after relative *** The serum sialic acid levels and positive ratio in malignant tumor groups are apparently higher than that in normal control and benign disease groups（P＜0.01）,the serum sialic acid levels in malignant tumor of different pathological types is apparently higher than that in normal control and benign disease groups（P＜0.01）,while there is no significance between different pathological types（P＞0.05）,the serum sialic acid levels in the improved patients significantly descent（P＜0.01）,while that in the aggravated patients has an ascendent *** The serum sialic acid has significant value in diagnosis,therapeutic effect and prognosis of malignant tumor.

关键词： serum sialic acid malignant tumor diagnosis value

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A study of the potential adverse effects of electrosurgical smoke on medical staff during malignant tumor surgery

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Oncology and Translational Medicine 2021年第3期7卷 136-140页

作者： Zhaoxia Luo Xiuze Li Shuhua Li Bo Hou Operation Room Mianyang Central HospitalMianyang 621000China Department of Anesthesiology Mianyang Central HospitalMianyang 621000China Department of Otolaryngology Mianyang Central HospitalMianyang 621000China

Objective The aim of this study was to investigate the potential adverse effects of electrosurgical smoke on medical staff performing malignant tumor *** This study was divided into two parts:in vitro and in vivo *** human thyroid cancer cell line,ARO,was cultured and *** tumor cells were burned with an ultrasonic scalpel,and the surgical smoke was absorbed by a transwell *** captured particles were diluted in 3 mL of culture medium,and cell survival was assessed under a *** was extracted from the cells for ***/c mice were used to construct thyroid cancer xenograft *** tumor tissues were dissected on day 14 using an ultrasonic *** smoke from the electrosurgical procedure was collected on a transwell *** membrane was washed in 2 mL of rinsing solution,and the solution was then injected into the right armpit of 10 *** sacrifice,the tumor tissues were removed and stained with hematoxylin and eosin(HE).Results Viable ARO cells could be seen on the first day after culturing cell fragments from surgical smoke,and vigorous cell proliferation could be seen on the 17th day of *** genotype of the cells cultured in the presence of smoke particles was identical to the genotype of the original *** growth was observed in four out of 10 mice injected with the smoke particle *** staining showed a significantly increased number of nuclei in the tumor tissue,which was consistent with the general morphological characteristics of malignant *** Viable tumor cells were detected in surgical smoke generated by ultrasonic scalpel dissection,and these cells had growth ***,it is necessary to protect patients and medical staff from electrosurgical smoke.

关键词： electrosurgery ultrasonic scalpel malignant tumor smoke

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A clinical trial of cytokine induced killer cells treating patients with malignant tumor after radiochemotherapy

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The Chinese-German Journal of Clinical Oncology 2010年第11期9卷 656-659页

作者： Jing Tian Donghai Teng Department of Oncology The People＇s Hospital of Leshan Leshan 614000 China Department of Urology The People＇s Hospital of Leshan Leshan 614000 China

Objective: Our study investigated the immunity changes and life quality changes after the treatment of cytokine induced killer (CIK) cells for patients with malignant tumor after radiochemotherapy, and explored the therapeutic effects of CIK cells on these patients. Methods: Thirty-one patients with malignant tumor after radiochemotherapy were treated with CIK cells. Before and after CIK cells being transfused back, the immunity indexes of the peripheral blood of these cases were detected and the changes of life quality of these cases were compared. Results: After radiochemotherapy, the percentage of CD3+, CD4+ cells declined, the percentage of CD8+ cells rose; the ratio of CD4+/CD8+ declined, and the percentage of CD16+, CD56+ cells declined. As all the above indexes compared with that of normal people, the difference was significant (P malignant tumor. CIK cells therapy is safe and effective. It may improve the recent immunity and life quality of the patients, which suggesting that it may be an alternative maintenance treatment for patients with malignant tumor after radiochemotherapy.

关键词： cytokine induced killer (CIK) immunity malignant tumor radiochemotherapy

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Nonmyeloablative allogeneic peripheral blood hematopoietic stem cells transplantation for advanced malignant tumor

Nonmyeloablative allogeneic peripheral blood hematopoietic s...

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第十届亚太国际骨髓移植会议

作者： MA lihui LI baoping QIAO zhenhua LIU zhuola SU liping .XIAO chuanshi .ZHENG zhuanzhen. The Second Hospital Of SHAN XI Medical University.TaiYuan.030001 China

＜正＞Objective To report 3 cases of advanced malignant tumor ofter nonmyeloablative allogeneic peripheral blood hematopoietic stem cells transplantation （NAPBSCT）and subsequently evaluate its effect and safety. Methods 3 cases report and literature review. Results after nonmyeloablative allogeneic peripheral blood hematopoietic stem cells transplantation,for 3 cases of patients suffered from advanced malignant tumor（lung cancer, malignant thymoma）,the allogeneic stem cells were engrafted *** to now

关键词： hematopoietic stem cells transplantation therapy malignant tumor

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Effect of purulent moxibustion on Zúsānlǐ(足三里ST 36) point on the clinical symptoms of patients with malignant tumor

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World Journal of Acupuncture-Moxibustion 2009年第4期19卷 14-18页

作者：雷海燕上海市金山区中心医院枫泾分院针灸科

Objective To discuss the effect of purulent moxibustion on Zusanli （足三里 ST 36） point on the clinical symptoms and life quality of patients with malignant tumor. Methods Sixty patients with malignant tumor were divided into an observation group and a control group with 30 cases in each group. The observation group was treated with purulent moxibustion on Zusanli （足三里 ST 36） in combination with herbal medicine; the control group was only treated with herbal medicine. After 80 days, the changes of the clinical symptoms and KPS of the two groups before and after the treatment were observed. Results The effective rates for the improvement of lassitude, poor appetite and insomnia in the observation group were 72.4% （21/29） ,25.0% （15/20） ,71.4% （15/21）, and those in the control group were 42.9%（12/28） ,55.6% （10/18） ,42.9% （6/14）, and there was no statistical significance of difference between the two groups（P〉0.05）. KPS has statistical significance in the two groups after the treatment （P〈0.01）,and the observation group was higher than the control group. Conclusion Purulent moxibustion on the point of Zusanli （足三里 ST 36） has certain effect to improve the clinical symptoms of patients with malignant tumor, and raise KPS and upgrade the life quality of patients.

关键词： Purulent Moxibustion Zusanli (足三里 ST 36) malignant tumor Clinical Symp- tom KPS

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