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The effects of fluoride and sulfur dioxide on male reproduction function

The effects of fluoride and sulfur dioxide on male reproduct...

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中国畜牧兽医学会动物毒物学分会2009年学术研讨会

作者： ZHAnG J H,nIU R Y,WAnG J M,WAnG J D (Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine,Shanxi Agricultural University,Taigu,Shanxi 030801,China)

Fluoride and sulfur dioxide are two well known environ ment pollutants,co-existing in some places,which present a serious threat to public *** order to explore the potential toxic effects of the two pollutants on the male reproduction and the mechanism of their interactio n,sexually matured rats and unmatur ed mice were treated with fluoride (100mg/L naF) and sulfur dioxide (39.3 mg/m SO,4hr/day),and fluoride(150mg/L naF) and sulfur dioxide(26.2mg/m SO,3hr/day), *** diverse methods as radioimmunoassay, transmission electronic microscopic, flow cytometry(FCM) and Terminal deoxynucleotidyl Transferase Bioti n-dUTP nick End Labeling(TUnE L),immunohidtochemidtry and Real-time PCR,this study dynamica lly observed the changes of sperm quality,morphology and subcellular structure of testis,protein level, antioxidation and the activity of relative enzymes in testis,apoptosis in seminaferous cell and the expressi on of p53,bcl-2,bax gene in these two kinds of ***, miRnA microarray,a new explored technology,was used to examined the changes of non-coded RnA in order to study the mechanism of effects of these two elements on the *** results indicate that Fluoride and sulfur dioxide can induce the damage of male reproduc tive system including the changes in structure of tissues,cell and molecu lar level so that significantly destroy the reproductive *** toxic effect of fluoride is in coordination with sulfur dioxide,the mechanism of which may be that fluoride and sulfur dioxide produce oxidative stress in testis tissue,disrupt the DnA single chain,activate DnA-PK, and induce phosphorylation and activation of p53 *** re,the activated p53 protein can enhance the expression of apoptosis gene such as bcl-2,bax et *** start spermatogenic cells apoptosis, finally impair spermiogenesis. Maybe the regulation of miRnAs existed during this process.

关键词： Apoptosis Fluoride and sulfur dioxide male reproductio n function MicroRnA Spermatoge nic cells

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