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Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic malays

World Journal of Gastroenterology 2013年第23期19卷 3615-3622页

作者： Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil Human Genome Center School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Medicine School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Max Planck Independent Research Group on Population Genomics Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences200031 Shanghai China Department of Immunology School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Surgery School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Paediatrics School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia

AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as "cases". Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as "controls". Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in "cases" vs "controls" for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic malays susceptible to H. pylori infection were identified for testing in subsequent trials.

关键词： Gastric precancerous lesions Gene polymorphisms Genome-wide association Helicobacter pylori malays

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Rome Ⅲ survey of irritable bowel syndrome among ethnic malays

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World Journal of Gastroenterology 2012年第44期18卷 6475-6480页

作者： Yeong Yeh Lee Anuar Waid Huck Joo Tan Andrew Seng Boon Chua William E Whitehead Department of Medicine School of Medical SciencesUniversity Sains MalaysiaKubang Kerian 16150Malaysia Department of Gastroenterology Sunway Medical CenterPetaling Jaya 46150Malaysia 31 Lebuh Raya Raman Ipoh Ipoh Garden SouthIpoh 31400Malaysia Center for Functional Gastrointestinal and Motility Disorders University of North Carolina at Chapel HillChapel HillCA 27599-7080United States

AIM:To survey irritable bowel syndrome(IBS) using Rome Ⅲ criteria among malays from the north-eastern region of Peninsular ***:A previously validated Malay language Rome Ⅲ IBS diagnostic questionnaire was used in the current study.A prospective sample of 232 Malay subjects(80% power) was initially *** a stratified random sampling strategy,a total of 221 Malay subjects(112 subjects in a "full time job" and 109 subjects in "no full time job") were *** were visitors(friends and relatives) within the hospital compound and were representative of the local *** flags and psychosocial alarm symptoms were also assessed in the current study using previously translated and validated *** with IBS were sub-typed into constipation-predominant,diarrhea-predominant,mixed type and *** and multivariable analyses were used to test for association between socioeconomic factors and presence of red flags and psychosocial alarm features among the malays with ***:IBS was present in 10.9%(24/221),red flags in 22.2%(49/221) and psychosocial alarm features in 9.0%(20/221).Red flags were more commonly reported in subjects with IBS(83.3%) than psychosocial alarm features(20.8%,P < 0.001).Subjects with IBS were older(mean age 41.4 years vs 36.9 years,P = 0.08),but no difference in gender was noted(P = 0.4).Using univariable analysis,IBS was significantly associated with a tertiary education,high individual income above RM1000,married status,exsmoker and the presence of red flags(all P < 0.05).In multiple logistic regression analysis,only the presence of red flags was significantly associated with IBS(odds ratio:0.02,95%CI:0.004-0.1,P < 0.001).The commonest IBS sub-type was mixed type(58.3%),followed by constipation-predominant(20.8%),diarrheapredominant(16.7%) and un-subtyped(4.2%).Four of 13 Malay females(30.8%) with IBS also had menstrual *** subjects with IBS had at least one red flag(70.8%)

关键词： Irritable bowel syndrome malays Preva-lence Rome Ⅲcriteria malaysia

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Intercultural Communication Competence Developed by Chinese in Communicating With malays in Bangka Island, Indonesia

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Sino-US English Teaching 2015年第4期12卷 299-309页

作者： Deddy Mulyana Agustina Zubair Padjadjaran University Bandung Indonesia University ofMercu Buana Jakarta Indonesia

This study aims to explore the cultural identity of Chinese related to their self-perception, their perception of malays, and their communication with the malays in Bangka Island, Indonesia, emphasizing the Chinese intercultural communication competence in terms of their self-presentation in business relationships with the malays. The study employed an interpretive approach, more specifically the symbolic interactionlst and dramaturgical tradition. The researchers focused on intercultural communication experiences and competence as enacted by the 25 Chinese in the area of the research. The study used in-depth interviews with the Chinese as the main method with some observation of the Chinese communication with the malays. The researchers also interviewed eight malays as additional subjects of the research to corroborate the research findings. The study found that the Chinese in Bangka Island perceived themselves as open and willing to mingle with the malays They are hospitable, hardworking, tenacious, frugal, and fond of maintaining long-term relationships. In contrast, in the Chinese view, the malays are open and willing to mingle with others, obedient to the teachings of Islam, but they are lazy and are keen on being flattered, consumptive, and easily seduced. In terms of their intercultural communication competence, the Chinese are skillful in their self-presentation by employing various verbal and nonverbal tactics to adjust themselves to the interpersonal, group, and business situations where they encounter the malays in their everyday lives

关键词： Chinese malays Bangka Island self-perception intercultural communication competence tactics ofself-presentation

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