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Attribution retraining group therapy for outpatients with major depression disorder,generalized anxiety disorder,and obsessive-compulsive disorder:a pilot study

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The Journal of Biomedical Research 2011年第5期25卷 348-355页

作者： Chun Wang Jie Zhang Jijun Li Ning Zhang Yalin Zhang Department of Medieal Psychology Nanjing Brain Hospital. Nanjing Jiangsu 210029 China Mental Health Institute. Second Xiangya Hospital Central South University Changsha Wuhan 410011 China Department of Psychological Counseling Shandong University of Science and Technology Qingdao Shandong 266510 China.

The aim of this present study is to examine the efficacy of attribution retraining group therapy （ARGT） and to compare the responses of outpatients with major depression disorder （MDD）, generalized anxiety disorder （GAD） and obsessive-compulsive disorder （OCD）. We carried out a prospective uncontrolled intervention study with a 8-weeks of ARGT on sixty three outpatients with MDD, GAD or OCD. Hamilton rating scale for depression, Hamilton rating scale for anxiety, Yale-Brown obsessive-compulsive scale, attribution style questionnaire, self-esteem scale, index of well-being, and social disability screening schedule were administered before and after treatment. Significant improvement in symptoms and psychological and social functions from pre- to posttreatment occurred for all participants. The changes favored MDD patients. Our study suggested that ARGT may improve the symptoms and psychological-social functions of MDD, GAD, and OCD patients. MDD patients showed the best response.

关键词： attribution retraining group psychotherapy major depression disorder generalized anxiety disorder obsessive-compulsive disorder

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Updated Understanding of the Glial-Vascular Unit in Central Nervous System disorders

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Neuroscience Bulletin 2023年第3期39卷 503-518页

作者： Di Yao Ruoying Zhang Minjie Xie Fengfei Ding Minghuan Wang Wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Key Laboratory of Neurological Diseases of the Chinese Ministry of Education School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordinated reactions to diverse neurological insults from a“glio-centric”view.GVU is a multicellular structure composed of glial cells,perivascular cells,and perivascular space.Each component is closely linked,collectively forming the GVU.The central roles of glial and perivascular cells and their multi-level interconnections in the GVU under normal conditions and in central nervous system(CNS)disorders have not been elucidated in detail.Here,we comprehensively review the intensive interactions between glial cells and perivascular cells in the niche of perivascular space,which take part in the modulation of cerebral blood flow and angiogenesis,formation of the blood-brain barrier,and clearance of neurotoxic wastes.Next,we discuss dysfunctions of the GVU in various neurological diseases,including ischemic stroke,spinal cord injury,Alzheimer’s disease,and major depression disorder.In addition,we highlight the possible therapies targeting the GVU,which may have potential clinical applications.

关键词： Glial-vascular unit Perivascular space Blood-brain barrier Glymphatic system Ischemic stroke Spinal cord injury Alzheimer's disease major depression disorder

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Nonspecific Effect of Stress on Brain Gray Matter Volume in Drug-naive Female Patients with First Depressive Episode

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Chinese Medical Journal 2016年第3期129卷 279-283页

作者： Chuan-Jun Zhuo Hai-Man Bian Yan-Jie Gao Xiao-Lei Ma Sheng-Zhang Ji Meng-Yuan Yao NJng Zhai Xin-Hai Sun Xiao-Yan Ma Hong-Jun Tian Gong-Ying Li Department of Psychiatry Tianjin Mental Health Center Tianjin Anding Hospital Tianjin 300222 China Department of Psychiatry Tianjin Anning Hospital Tianjin 300300 China Department of Radiology Tianjin 4th Centre Hospital Tianjin 300143 China Department of Psychiatry Jining Medical University Jining Shandong 272013 China Oepartment of Magnetic Resonance Imaging Affiliated Hospital of Jining Medical University Jining Shandong 272000 China Department of Psychiatry Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120 China

Background： This study aimed to observe the differences in brain gray matter volume in drug-naive female patients after the first episode of major depression with and without stressful life events （SLEs） before the onset of depression.Methods： Forty-three drug-naive female patients voluntarily participated in the present study after the first major depressive episode.The life event scale was used to evaluate the severity of the impact of SLEs during 6 months before the onset of the major depressive episode.High-field magnetic resonance imaging （MRI） scans were obtained, and the VBM and SPM8 software process were used to process and analyze the MRI.Results： Compared to that in patients without SLEs, the volume of brain gray matter was lower in the bilateral temporal lobe, right occipital lobe, and right limbic lobe in the SLE group.However, the gray matter volume did not differ significantly between the two groups after the application of false discovery rate （FDR） correction.Conclusions： Although the results of the present study suggest the absence of significant differences in brain gray matter volume between female drug-naive patients after the first episode of major depression with and without SLEs after FDR correction, the study provides useful information for exploring the definitive role of stress in the onset of depression.

关键词： First Episode Gray Matter Volume Magnetic Resonance Imaging major depression disorder Stressfid Life Events

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Lentivirus-mediated knockdown of phosphodiesterase 4D improved depression-like behaviors in mice

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中国药理学与毒理学杂志 2016年第10期30卷 1020-1021页

作者： ZHANG Cong CHENG Yu-fang NIU Bo XU Jiang-ping Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical University

OBJECTIVE To examine whether long-form phosphodiesterase-4(PDE4)knockdown by lentiviral RNA construct containing a speci fi c micro RNA/mi RNAmir hairpin structure reversed depression-like symptoms caused by chronic unpredictable mild stress(CUMS)in mice.METHODS In this research,the study was performed on adult male C57 mice,weighing(25±5)g,kept in a controlled environment.CUMS animal model was used recapitulate a multiple of behavioral characteristics and biochemical states of depression in human.The forced swimming test(FST)and the tail suspension test(TST)were used to detectthe state of depression.Western blotting analysis was used to assess protein levels of c AMP response element binding protein(CREB,unphosphorylated and phosphorylated[p CREB])to explore the neurochemical mechanisms.RESULTS CUMS decreased c AMP levels(Pdepression-like symptoms in FST(Pdepression-like symptoms.Moreover,CUMS caused a significant reduction in protein kinase A and CREB phosphorylation,and brain-derived neurotrophic factor transcription,both of which were partially attenuated by lentivirus-mediated knockdown of PDE4D.Also,the phosphorylation of extracellular signal-regulated kinase 1/2 was reduced in CUMS-exposed mice,which was reversed by 4Dmi RNA treatment.Taken together,this study demonstrated that PDE4Dmi RNA improved the CUMS-induced depressionlike symptoms that might be related to the increase in hippocampal c AMP and p CREB expression.CONCLUSION Hence,PDE4D inhibitors can serve as potential antidepressants,and their antidepressant activity is partially mediated by the activation of c AMP signaling pathway in the hippocampus.In other words,long-form PDE4D knockdown may offer a promising treatment for major depression disorder.

关键词： antidepressant CREB long-form PDE4D major depression disorder

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