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Research progress on the electrophysiological indicators to predict the efficacy of vagus nerve stimulation for drug-refractory epilepsy

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Acta Epileptologica 2024年第1期7卷 14-20页

作者： Guangli Li Zhenguang Li Yingting Liu Hunan University of Chinese Medicine Changsha410208Hunan ProvinceChina Epilepsy Center of Brain Hospital of Hunan Province Changsha410007Hunan ProvinceChina

Vagus nerve stimulation(VNS)is an important treatment option for drug-refractory epilepsy(DRE),with well-established efficacy and safety in clinical practice for more than 20 years.However,it is very difficult to find the optimal electrophysiological indicators for the effectiveness of VNS on DRE because the mechanism of action is unknown.In this review,we provide an update of the potential applications of VNS outcomes in patients with drug-resistant epilepsy.Electroencephalographic(EEG)activity,event-related potentials,EEG synchronization levels,magnetoencephalographic,laryngeal muscle evoked potentials,and heart rate variability are potential biomarkers for VNS outcomes in people with DRE.

关键词： Electrophysiology Vagus nerve stimulation Drug-refractory epilepsy Efficacy Predictive indicators Electroencephalogram Event-related potential magnetoencephalography Aryngeal muscle evoked potential Heart rate variability

Changes of auditory evoked magnetic fields in patients after acute cerebral infarction using magnetoencephalography

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Neural Regeneration Research 2012年第24期7卷 1906-1913页

作者： Zhanyong Sun Chunfeng Song Jilin Sun Ling Li Yanhong Dong Jianhua Wang Jie Wu Wenzhu Cui Yujin Wu Peiyuan Lv Department of Neurology Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Institute of Basic Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of magnetoencephalography Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Neurology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

Auditory evoked magnetic fields were recorded from 15 patients with acute cerebral infarction and 11 healthy volunteers using magnetoencephalography.The auditory stimuli of 2 kHz pure tone were binaurally presented with an interstimulus interval of 1 second.The intensity of stimuli was 90 dB and the stimulus duration was 8 ms.The results showed that the M100 was the prominent response, peaking approximately 100 ms after stimulus onset in all subjects.It originated from the area close to Heschl’s gyrus.In the patient group,the peak latency of M100 responses was significantly prolonged,and the mean strength of equivalent current dipole was significantly smaller in the affected hemisphere.The three-dimensional inter-hemispheric difference of the M100 positions was increased in the patient group.Our experimental findings suggested that impairment of cerebral function in patients with acute ischemic stroke can be detected using magnetoencephalography with the higher spatial resolution and temporal resolution.magnetoencephalography could provide objective and sensitive indices to estimate auditory cortex function in patients with acute cerebral infarction.

关键词： acute cerebral infarction cerebral ischemia magnetoencephalography auditory evoked magnetic fields equivalent current dipole Heschl’s gyrus brain functional impairment nerve injury regeneration neural regeneration

Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects： functional MRI and magnetoencephalography

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Chinese Medical Journal 2006年第18期119卷 1548-1554页

作者： ZHANG Yun-ting GENG Zuo-jun ZHANG Quan LI Wei ZHANG Jing Department of Radiology General Hospital of Tianjin Medical University Tianjin 300052 China Department of Radiology Second Hospital of Hebei Medical University Shijiazhuang 050000 China

Background Blood oxygen level dependent functional magnetic resonance imaging （fMRI） and magnetoencephalography are new techniques of brain functional imaging which can provide the information of excitation of neurons by measure the changes of hemodynamics and electrophysiological data of local brain tissue. The purpose of this study was to study functional brain areas evoked by pure tones in healthy and sensorineural hearing loss subjects with these techniques and to compare the differences between the two groups. Methods Thirty healthy and 30 sensorineural hearing loss subjects were included in this study. In fMRI, block-design paradigm was used. During the active epoch the participants listened to 1000 Hz, sound pressure level 140 dB pure tones at duration 500 ms, interstimulus interval 1000 ms, which presented continuously via a magnetic resonance-compatible audio system. None stimulus was executed in control epoch. In magnetoencephalography study, every subject received stimuli of 1000 Hz tone bursts delivered to the bilateral ear at duration 8 ms, interstimulus intervals 1000 ms. Sound pressure level in healthy subjects was 30 dB; in sensorineural hearing loss subjects was 20 dB above everyone＇ s hearing threshold respectively. All subjects were examined with 306-channel whole-scalp neuromagnetometer. Results In fMRI, all subjects showed significant activations in bilateral Heschl＇s gyri, anterior pole of planum temporale, planum temporale, precentral gyri, postcentral gyri, supramarginal gyri, superior temporal gyri, inferior frontal gyri, occipital lobes and cerebellums. The healthy subjects had more intensive activation in bilateral Heschl＇s gyri, anterior pole of planum temporale, inferior frontal gyri, left superior temporal gyri and right planum temporale than the hearing loss subjects. But in precentral gyri, postcentral gyri and occipital lobes, the activation is more intensive in the hearing loss subjects. In magnetoencephalography study, both in the hearing loss and the healthy subjects, the m

关键词： functional magnetic resonance imaging magnetoencephalography pure tones auditory cortex

Neuroimaging studies of bilingual expressive language representation in the brain:potential applications for magnetoencephalography

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Neuroscience Bulletin 2012年第6期28卷 759-764页

作者： Elizabeth W.Pang Division of Neurology Hospital for Sick Children Neurosciences and Mental Health Sick Kids Research Institute Department of Paediatrics University of TorontoTorontoOntario M5G 1x8Canada

Bilingualism is the ability to use two or more languages with equal or near equal fluency. How the brain, often seamlessly, selects, controls, and switches between languages is an enigma. Neuroimaging studies offer the unique opportunity to probe the mechanisms underlying bilingual brain function. Non-invasive methods, in particular, functional MRI （fMRI） and event-related potentials （ERPs）, have allowed examination in healthy control populations. Whole-head magnetoencephalography （MEG）, a relatively new addition to the cadre of neuroimaging tools, offers a combination of the high spatial resolution of fMRI with the high temporal resolution of ERPs. Thus far, MEG has been applied to the studies of bilingual receptive language, or bilingual language comprehension. MEG has not yet been applied to the study of bilingual language production as such studies have faced more challenges （see Salmelin, 2007 for a review）, and these have only recently been addressed. Here, we review the literature on MEG expressive language studies and point out a direction for the application of MEG to the study of bilingual language production.

关键词： magnetoencephalography bilingualism expressive language

Differential temporal neural responses of pain-related regions by acupuncture at acupoint ST36： a magnetoencephalography study

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Chinese Medical Journal 2011年第8期124卷 1229-1234页

作者： CHENG Hao ZHANG Xiao-tong YAN HAO BAI Li-jun AI Lin WANG Feng-bin YOU You-bo CHEN Peng WANG Bao-guo Department of Anesthesiology Beijing Tiantan Hospital Capital Medical UniversityBeijing 100050 China Department of Anesthesiology Beijing Stomatological HospitalCapital Medical University Beijing 100050 China School of Psychology Shaanxi Normal University Xi'an Shaanxi710062 China Medicai Image i~rocessing Group Institute of Automation ChineseAcademy of Sciences Beijing 100190 China Department of Radiology Beijing Tiagntan Hospital Capital Medical UniversityBeijing 100050 China Beijing Traditional Chinese IVledicine Hospital Capital MedicalUniversity Beijing 100010 China Beijing Sanbo Brain Hospital Capital Medical University Beijing100093 China

Background Previous neuroimaging studies primarily focused on the spatial distribution of acupuncture needling stimulation. However, a salient feature of acupuncture was its long-lasting effect. This study attempted to detect the spatial-temporal neural responses evoked by acupuncture at an analgesia acupoint ST36 by using magnetoencephalography. To further verify its functional specificity, we also adopted acupuncture at Pericardium 6 and nonacupoint as separated controls.Methods Forty-two college students, all right-handed and acupuncture naive, participated in this study. Every participant received only one acupoint stimulation, resulting in 14 subjects in one group. Both magnetoencephalography data （151-channel whole-head system） and structural functional magnetic resonance imaging data （3D sequence with a voxel size of 1 mm3 for anatomical localization） were collected for each subject. All processing procedures were performed in BrainStorm Toolbox.Results Acupuncture at ST36 showed a significantly time-varied brain activities with different onset time. Our results presented that acupuncture at different acupoints （or comparing with nonacupoint） can specifically induce neural responses in different brain areas-acupuncture at ST36 can specifically induce the neural responses of pain-inhibition areas, while acupuncture at PC6 can specifically induce the activities of the insula and amygdala.Conclusions In the present study, we attempted to detect the temporal neural responses underlying the functional specificity of acupuncture at ST36, using acupoint belonging to different meridians and non-acupoint with efficacy-irreverent as separate controls. The specific neural substrates involving acupuncture at different acupoints may be related to its functional specificity in clinical settings.

关键词： acupuncture functional specificity magnetoencephalography structural MRI spatial-temporal information

Localization of epileptic foci in Children with childhood absence epilepsy by magnetoencephalography combined with synthetic aperture magnetometry

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The Journal of Biomedical Research 2011年第4期25卷 259-265页

作者： Xiuxiu Hu Jingde Dong XiaoshanWang Ting Wu Lu Yang Xiaopeng Lu Department of Gen＇atrie Neurology Nangjing Brain Hospital Nanjing Jiangsu 210029 China Magnetoeneephalography Center Nangjing Brain Hospital Nanjing Jiangsu 210029 China Department of Neurology Nanjing Children＇s Hospital Nanjing Jiangsu 210029 China

This present study was aimed to investigate the localizable diagnostic value of magnetoencephalography （MEG） combined with synthetic aperture magnetometry （SAM） in childhood absence epilepsy （CAE）. Thirteen CAE patients underwent MEG detection at resting state and after hyperventilation, and then the epileptic loci were located by SAM. In the thirteen CAE patients, epileptic foci were found in five cases （38.5%）, and they were all located in the bilateral frontal lobe, suggesting that the frontal lobe in some CAE patients may serve as the epileptic foci. Our findings indicate that MEG combined with SAM could be of diagnostic value in localizing the epileptic foci in certain CAE patients.

关键词： childhood absence epilepsy magnetoencephalography synthetic aperture magnetometry epileptic loci

Zero field optically pumped magnetometer with independent dual-mode operation

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Chinese Optics Letters 2022年第8期20卷 18-23页

作者：张少文陆吉玺周莹逯斐尹凯峰詹迪翟跃阳叶茂 School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Hangzhou Innovation Institute of Beihang University Hangzhou 310051China Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310023China Research Institute for Frontier Science Beihang UniversityBeijing 100191China

We propose a dual-mode optically pumped magnetometer(OPM)that can flexibly switch between single-beam modulation mode and double-beam DC mode.Based on a 4 mm×4 mm×4 mm miniaturized vapor cell,the double-beam DC mode achieves a sensitivity of 7 fT=Hz^(1/2) with probe noise below 4 fT=Hz^(1/2) and working bandwidth over 65 Hz.This mode is designed to precisely measure the noise floor of a mu-metal magnetic shield.The single-beam modulation mode(sensitivity 20 fT=Hz^(1/2))exhibits bandwidth characteristics suitable for biomagnetic measurements.Thus,our design is suitable for a miniaturized OPM with multiple functions,including magnetic-shield background noise measurement and medical imaging.

关键词： optically pumped magnetometer atomic optics dual-mode magnetometer magnetoencephalography medical imaging

Optical Rotation Detection for Atomic Spin Precession Using a Superluminescent Diode

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Photonic Sensors 2019年第2期9卷 135-141页

作者： Xuejing LIU Yang LI Hongwei CAI Ming DING Jiancheng FANG Wei JIN School of Inst ru men ta tion Science and Opto-electronics Engineering Beihang University Beijing 100191 China

A superluminescent diode (SLD) as an alternative of laser is used to detect optical rotation for atomic spin precession. A more uniform Gauss configuration without additional beam shaping and a relatively high power of the SLD have a potential for atomic magnetometers, which is demonstrated in theory and experiments. In addition, the robustness and compactness enable a more practical way for optical rotation detections, especially for applications in magnetoencephalography systems.

关键词： Superluminescent diode atomic magnetometer magnetoencephalography atomic spin precessiondetection Larmor precession

Females with schizophrenia have abnormal functional cortical connectivity in the gamma frequency during an auditory oddball task using magnetoencephalography

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Open Journal of Psychiatry 2014年第1期4卷 24-38页

作者： Toshiro Fujimoto Eiichi Okumura Kouzou Takeuchi Atsushi Kodabashi Toshiaki Otsubo Katsumi Nakamura Masaki Sekine Shinichiro Kamiya Yuji Higashi Susumu Shimooki Toshiyo Tamura Faculty of Biomedical Engineering Osaka Electro-Communication University Osaka Japan Fujimoto General Hospital Fujimoto Medical System Miyazaki Japan Neuroscience Project Office Yokogawa Electric Corporation Ishikawa Japan

We studied differences in imaginary coherence (IC) of the gamma band between brain regions of female schizophrenia patients during the auditory oddball task using magnetoencephalography (MEG). Subjects were 12 right-handed female schizophrenia patients, who were evaluated by the Positive and Negative Syndrome Scales (PANSS). Functional connectivity during an auditory oddball task was reconstructed in low gamma (30 - 50 Hz) and high gamma (50 - 100 Hz and 100 - 150 Hz) bands, and represented by IC using seeds determined by the significant oscillatory power changes obtained by event-related synchronization (ERS) and event-related desynchronization (ERD) power measurements. Gamma ERS (30 - 50 Hz) power was decreased in the left precuneus at 500 - 750 ms and in the right precuneus at 750 - 1000 ms. IC in the gamma band (50 - 100 Hz) was decreased between the right precuneus (seed) and right paracentral lobule (target) and between the right precuneus and right hypothalamus at 0 - 250 ms. IC in the gamma band (100 - 150 Hz) was increased between the left precuneus and right cuneus (Brodmann area 7) at 250 - 500 ms, between the left precuneus and right culmen at 500 - 750 ms, and between the left precuneus and right cuneus (Brodmann area 17), between the left precuneus and right posterior cingulate cortex, and between the left precuneus and right caudate nucleus at 750 - 1000 ms. In the high gamma band (50 - 100 Hz) at 0 - 250 ms, significant positive correlations were shown between IC and conceptual disorganization in PANSS scores, between IC and unusual thought content score, and between IC and positive scale score. IC within the high gamma band in female schizophrenia patients showed two types of functional disconnection, intrahemispheric and interhemispheric. IC between the right or left precuneus and other specific cortical areas showed dysfunction, suggesting that the parietal lobe plays an important role in dysfunction in connectivity in the gamma band during the oddball task.

关键词： Schizophrenia Female Gamma Band Coherence Functional Connectivity Oddball magnetoencephalography