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Comparative Study on Characteristics and Cytotoxicity of Bifunctional magnetic-silver nanostructures: Synthesized Using Three Different Reducing Agents

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Acta Metallurgica Sinica(English Letters) 2016年第4期29卷 326-334页

作者： Narjes Ebrahimi Sara Rasoul-Amini Alireza Ebrahiminezhad Younes Ghasemi Ahmad Gholami Hassan Seradj Department of Pharmaceutical Biotechnology School of Pharmacy Shiraz University of Medical Sciences Department of Medicinal Chemistry School of PharmacyShiraz University of Medical Sciences Shiraz Fars Iran Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Department of Medical Biotechnology School of MedicineFasa University of Medical Sciences Department of Pharmacognosy School of Pharmacy Shiraz University of Medical Sciences

magnetic-silver nanostructures were synthesized via optimized chemical conditions, and their characteristics and cytotoxicity were compared as candidates for the magnetic delivery of silver nanoparticles toward cancer cells. magnetic-silver nanostructures were prepared through the reduction of silver ions in the presence of iron oxide nanoparticles using three different reducing agents （glucose, maltose and sodium citrate）. Their physicochemical characteristics were determined using ultraviolet-visible spectroscopy, X-ray diffraction analysis, transmission electron microscopy, selected area electron diffraction analysis, Fourier transformed infrared spectroscopy, atomic absorption spectroscopy, vibrating sample magnetometry and differential scanning calorimetry. Cytotoxic activities were evaluated against a human liver hepatocellular carcinoma cell line. Fabricated nanostructures, which exhibit differences in size, silver content, magnetic saturation value and cytotoxicity, represent sufficient superparamagnetic properties and considerable cytotoxicity to be suggested as effective tools in magnetic targeting of silver nanoparticles as an approach to cancer therapy.

关键词： Bifunctional nanostructure magnetic-silver nanostructure silver nanoparticle Cytotoxicity Reducing agent

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