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Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 617-627页

作者： Xueqing YIN Xinzhong RUAN Yongmeng ZHU Yongfang YIN Rui HUANG Chao LIANG The First Affiliated Hospital of Ningbo University Ningbo 315000China Ningbo Medical Center Lihuili Hospital Ningbo 315000China

Objectiveperitoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging (GRASP DCE-MRI) to predict the presence of peritoneal free cancer cells in gastric cancer *** enrolled patients were consecutively divided into analysis and validation groups. Preoperative magnetic resonance imaging (MRI) scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid groups. The data collected included clinical and MR information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification *** was no statistical difference between the proportion of PLC-positive cases predicted by GRASP DCE-MR and the actual PLC test. MR tumor stage, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a concordance index (C-index) of 0.785 and 0.742 for the modeling and validation groups, *** DCE-MR could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.

关键词： Gastric cancer magnetic resonance Golden-angle radial sampling Nomogram model Peritoneal free cancer cells

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magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits

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Asian Journal of Andrology 2007年第3期9卷 361-367页

作者： Yun-Seob Song Ja-Hyeon Ku Eun-Seop Song Jung-Hoon Kim Jin-Suck Jeon Kong-Hee Lee Sook-Ja Kim Hee-Jeong Cheong Ik-Sung Lim Dongho Choi Jong-Ho Won Department of Urology Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Seoul National University Hospital Seoul 110-744 Korea Department of Obstetrics and Gynecology Inha University School of Medicine Incheon 400-103 Korea Department of Radiology Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Soonchunhyang School of Medicine Seoul 140-743 Korea Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Industrial Management ＆ Engineering Namseoul University College of Engineering Cheonan 330-707 Korea Department of Surgery Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea

Aim： To investigate whether the biological process of superparamagnetic iron oxide （SPIO）-labeled human mesenchymal stem cells （hMSCs） may be monitored non-invasively by using in vivo magnetic resonance （MR） imaging with conventional 1.5-T system examinations in corpus cavernosa of rats and rabbits. Methods： The labeling efficiency and viability of SP10-labeled hMSCs were examined with Prussian blue and Tripan blue, respectively. After SPIO-labeled hMSCs were transplanted to the corpus cavernosa of rats and rabbits, serial T2-weighted MR images were taken and histological examinations were carried out over a 4-week period. Results： hMSCs loaded with SPIO compared to unlabeled cells had a similar viability. For SPIO-labeled hMSCs more than lx 105 concentration in vitro, MR images showed a decrease in signal intensity. MR signal intensity at the areas of SPIO-labeled hMSCs in the rat and rabbit corpus cavernosa decreased and was confined locally. After injection of SPIO-labeled hMSCs into the corpus cavernosum, MR imaging demonstrated that hMSCs could be seen for at least 12 weeks after injection. The presence of iron was confirmed with Prussian blue staining in histological sections. Conclusion： SP10-labeled hMSCs in corpus cavernosa of rats and rabbits can be evaluated non-invasively by molecular MR imaging. Our findings suggest that MR imaging has the ability to test the long-term therapeutic potential of hMSCs in animals in the setting of erectile dysfunction.

关键词： human mesenchymal stem cells magnetic resonance stem cells penis cell labeling corpus cavemosa

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magnetic resonance diffusion tensor imaging-based evaluation of optic-radiation shape and position in meningioma

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Neural Regeneration Research 2012年第9期7卷 686-691页

作者： Xueming Lv Xiaolei Chen Bainan Xu Jiashu Zhang Gang Zheng Jinjiang Li Fangye Li Guochen Sun Department of Neurosurgery Chinese PLA General Hospital Chinese PLA Postgraduate Medical SchoolBeijing 100853China

Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surrounding brain tissue. A color-coded tensor map and three-dimensional tracer diagram were applied to clearly display the optic-radiation location, course and damage. Results showed that the altered anisotropy values of meningioma patients corresponded with optic-radiation shape, size and position on both sides. Experimental findings indicate that the magnetic resonance diffusion tensor imaging technique is a means of tracing and clearly visualizing the optic radiation.

关键词： magnetic resonance diffusion tensor imaging diffusion tensor tractography meningioma optic radiation

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magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction

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Neural Regeneration Research 2016年第7期11卷 1115-1121页

作者： Xiao-na Wu Tao Zhang Jun Wang Xiao-yan Liu Zhen-sheng Li Wei Xiang Wei-qing Du Hong-jun Yang Tie-gen Xiong Wen-ting Deng Kai-run Peng Su-yue Pan Department of Neurology Nanfang Hospital of Southern Medical University Department of Orthopedics Guangzhou General Hospital of Guangzhou Military Command Department of MRI Guangzhou General Hospital of Guangzhou Military Command Department of Neurology Guangzhou General Hospital of Guangzhou Military Command

Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether naajor ozonated autohelnotherapy affects remote in）ury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups. Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy （47 mg/L, 100 mL ozone） for 10 ± 2 days. Patients in the control group received medical treatment only. National Institutes of Health Stroke Scale score, modified Rankin scale score, and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased, brain function improved, clinical efficiency significantly increased, and no obvious adverse reactions detected in the ozone treatment group compared with the control group. These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing re,note injury, and additionally, exhibits high safety.

关键词： nerve regeneration ozone cerebral infarction magnetic resonance diffusion tensor imaging anisotropy internal capsule whitematter corticospinal tract cerebral peduncle neural regeneration

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magnetic resonance imaging-radiomics evaluation of response to chemotherapy for synchronous liver metastasis of colorectal cancer

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World Journal of Gastroenterology 2021年第38期27卷 6465-6475页

作者： Yan-Qing Ma Yang Wen Hong Liang Jian-Guo Zhong Pei-Pei Pang Department of Radiology Zhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Department of Radiology Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Department of Pharmaceuticals Diagnosis GE HealthcareHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Synchronous liver metastasis(SLM)is an indicator of poor prognosis for colorectal cancer(CRC).Nearly 50%of CRC patients develop hepatic metastasis,with 15%-25%of them presenting with *** evaluation of SLM in CRC is crucial for precise and personalized *** is beneficial to detect its response to chemotherapy and choose an optimal treatment *** To construct prediction models based on magnetic resonance imaging(MRI)-radiomics and clinical parameters to evaluate the chemotherapy response in SLM of *** A total of 102 CRC patients with 223 SLM lesions were identified and divided into disease response(DR)and disease non-response(non-DR)to *** standardizing the MRI images,the volume of interest was delineated and radiomics features were *** MRI-radiomics logistic model was constructed after methods of variance/Mann-Whitney U test,correlation analysis,and least absolute shrinkage and selection operator in feature *** radiomics score was *** receiver operating characteristics curves by the DeLong test were analyzed with MedCalc software to compare the validity of all ***,the area under curves(AUCs)of DWI,T2WI,and portal phase of contrast-enhanced sequences radiomics model(Ra-DWI,Ra-T2WI,and Ra-portal phase of contrast-enhanced sequences)were *** radiomicsclinical nomogram was generated by combining radiomics features and clinical characteristics of CA19-9 and clinical N *** The AUCs of the MRI-radiomics model were 0.733 and 0.753 for the training(156 lesions with 68 non-DR and 88 DR)and the validation(67 lesions with 29 non-DR and 38 DR)set,***,the AUCs of the training and the validation set of Ra-DWI were higher than those of Ra-T2WI and Ra-portal phase of contrast-enhanced sequences(training set:0.652 vs 0.628 and 0.633,validation set:0.661 vs 0.575 and 0.543).After chemotherapy,the top four of twelve deltaradiomics features of R

关键词： Radiomics Synchronous liver metastasis Colorectal cancer Chemotherapy magnetic resonance Nomogram

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Spin dynamics of magnetic resonance with parametric modulation in a potassium vapor cell

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Chinese Physics B 2017年第3期26卷 285-290页

作者：张锐汪之国彭翔黎文浩李松健郭弘 College of Science and Interdisciplinary Center for Quantum Information National University of Defense Technology Changsha 410073 China State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Engineering and Computer Science and Center for Quantum Information Technology Peking University Beijing 100871 China College of Optoelectronic Science and Engineering National University of Defense Technology Changsha 410073 China

A typical magnetic-resonance scheme employs a static bias magnetic field and an orthogonal driving magnetic field oscillating at the Larmor frequency, at which the atomic polarization precesses around the static magnetic field. Here we demonstrate both theoretically and experimentally the variations of the resonance condition and the spin precession dynamics resulting from the parametric modulation of the bias field. We show that the driving magnetic field with the frequency detuned by different harmonics of the parametric modulation frequency can lead to resonance as well. Also, a series of frequency sidebands centered at the driving frequency and spaced by the parametric modulation frequency can be observed in the precession of the atomic polarization. We further show that the resonant amplitudes of the sidebands can be controlled by varying the ratio between the amplitude and the frequency of the parametric modulation. These effects could be used in different atomic magnetometry applications.

关键词： atomic magnetometer magnetic resonance parametric modulation

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Combined effect of light intensity and temperature on the magnetic resonance linewidth in alkali vapor cell with buffer gas

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Chinese Physics B 2017年第6期26卷 417-421页

作者：高阳董海峰王翔王笑菲尹凌霄 School of Instrumentation Science and Opto-Electronics Engineering Beihang University Beijing 100191 China School of Electronic and Information Engineering Beihang University Beijing 100191 China

One of the peculiar phenomenons in non-zero magnetic resonance magnetometer is that, with the increase of the temperature, the magnetic resonance linewidth is narrowed at first instead of broadened due to the increasing collision rate. The magnetometer usually operates at the narrowest linewidth temperature to obtain the best sensitivity. Here, we explain this phenomenon quantitatively considering the nonlinear of the optical pumping in the cell and did experiments to verify this explanation. The magnetic resonance linewidth is measured using one amplitude-modulated pump laser and one continuous probe laser. The field is along the direction orthogonal to the plane of pump and probe beams. We change the temperature from 53℃ to 93℃ and the pumping light from 0.1 mW to 2 mW. The experimental results agree well with the theoretical calculations.

关键词： atomic magnetometer magnetic resonance linewidth temperature

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In vivo tracking of neuronal-like cells by magnetic resonance in rabbit models of spinal cord injury

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Neural Regeneration Research 2013年第36期8卷 3373-3381页

作者： Ruiping Zhang Kun Zhang Jianding Li Qiang Liu Jun Xie Department of Radiology First Hospital Shanxi Medical University Department of Radiology Medical Imaging Centre Navy General Hospital Department of Orthopedics Shanxi Dayi Hospital Department of Molecular Biology Shanxi Medical University

In vitro experiments have demonstrated that neuronal-like cells derived from bone marrow mesen- chymal stem cells can survive, migrate, integrate and help to restore the function and behaviors of spinal cord injury models, and that they may serve as a suitable approach to treating spinal cord injury. However, it is very difficult to track transplanted cells in vivo. In this study, we injected su- perparamagnetic iron oxide-labeled neuronal-like cells into the subarachnoid space in a rabbit model of spinal cord injury. At 7 days after cell transplantation, a small number of dot-shaped low signal intensity shadows were observed in the spinal cord injury region, and at 14 days, the number of these shadows increased on T2-weighted imaging. Perl＇s Prussian blue staining detected dot-shaped low signal intensity shadows in the spinal cord injury region, indicative of superpara- magnetic iron oxide nanoparticle-labeled cells. These findings suggest that transplanted neu- ronal-like cells derived from bone marrow mesenchymal stem cells can migrate to the spinal cord injury region and can be tracked by magnetic resonance in vivo. magnetic resonance imaging represents an efficient noninvasive technique for visually tracking transplanted cells in vivo.

关键词： neural regeneration neuronal-like cells bone marrow mesenchymal stem cells stern cells bone marrow in vivo tracking magnetic resonance transplantation grants-supported paper neuroregeneration

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3.0-T magnetic resonance imaging in children with brachial plexus birth injury

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Neural Regeneration Research 2011年第6期6卷 474-480页

作者： Shinong Pan Lijie Tian Wei Liao Feng Tian Jian Mao Fei Wang Rongjie Bai Qi Li ZhianChen Qiyong Guo Department of Radiology Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Orthopedic Surgery Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Neonatal Medicine Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Radiology Beijing Jishuitan Hospital Beijing 100035 China

Brachial plexus birth injuries in children are usually diagnosed using 1.5-T magnetic resonance imaging, while the application of high-field magnetic resonance imaging is rarely reported. Therefore, a retrospective comparison of 18 cases of children with brachial plexus injury was performed to investigate the characteristics of 3.0-T magnetic resonance imaging and intraoperative observations. magnetic resonance examinations in 18 cases of children showed that pseudo-meningocele sensitivity, specificity, accuracy, and positivity rates were 83.3%, 79.6%, 81.1%, and 40.0%, respectively. As for the neuroma and fibrous scar encapsulation, the sensitivity, specificity, accuracy, and positivity rates were 92.9%, 50.0%, 83.3%, and 77.8%, respectively. These results confirm that 3.0-T high-field magnetic resonance imaging can clearly reveal abnormal changes in brachial plexus injury, in which pseudo-meningocele, fibrous scar encapsulation, and neuroma are the characteristic changes of obstetric brachial plexus preganglionic and postganglionic nerve injury.

关键词： magnetic resonance brachial plexus children delivery injury neuroimaging

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Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer

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World Journal of Clinical Cases 2022年第21期10卷 7333-7340页

作者： Zhe Wang Guan-Ying Ren Qian Yin Qian Wang Department of Medical Imaging The No.2 Hospital of BaodingBaoding 071051Hebei ProvinceChina Department of Medical Oncology Affiliated Hospital of Hebei UniversityHebei Key Laboratory of Cancer Radiotherapy and ChemotherapyBaoding 071000Hebei ProvinceChina

BACKGROUND China ranks 120th worldwide for the incidence of breast cancer and 163rd for *** screening,diagnosis,and timely determination of the optimal treatment plan can help ensure clinical efficacy and *** To investigate the relationship between quantitative magnetic resonance imaging parameters,apparent diffusion coefficient value,pathological immunohistochemical status,and patient *** A total of 108 patients with breast cancer(breast cancer group)and 110 patients with benign breast tumors(benign group)confirmed by pathological examination at our Hospital from September 2013 to August 2016 were *** patients had undergone preoperative magnetic resonance imaging(MRI)examinations,and the quantitative parameters of MRI and apparent diffusion coefficient(ADC)values for the two groups were *** MRI quantitative parameters and ADC values of patients with different estrogen receptor(ER),progesterone receptor,and human epidermal growth factor receptor-2 expression were statistically *** relationship between the quantitative parameters of MRI and ADC values and patient recurrence was analyzed using receiver operating *** The measured values of the quantitative parameters of MRI-Ktrans,Kep,and Ve in the breast cancer group were higher than those in the benign group;the ADC value in the breast cancer group was lower than that in the benign group,and the difference was statistically significant(P<0.05).The Ktrans,Ve,and ADC values in patients with ER-positive breast cancer were significantly lower than those in patients with negative ER expression(P<0.05).After 5 years of follow-up,22 patients with breast cancer experienced postoperative *** Kep,Ve,and ADC values of the recurrence group were significantly lower than those of the non-recurrence group,and the difference was statistically significant(P<0.05).CONCLUSION MRI quantitative parameters and ADC are related to the expression of breast c

关键词： magnetic resonance Apparent diffusion coefficient Breast cancer Immunohistochemistry Prognosis

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