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nanomotor-based adsorbent for blood Lead(II)removal in vitro and in pig models

Bioactive Materials 2021年第4期6卷 1140-1149页

作者： Meng Wang Tianyi Bao Wenqiang Yan Dan Fang Yueqi Yu Zhiyong Liu Guoyong Yin Mimi Wan Chun Mao Dongquan Shi National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023PR China Department of Sports Medicine and Adult Reconstructive Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008PR China Department of Orthopaedics the First Affiliated Hospital of Nanjing Medical University Nanjing210029PR China

Blood lead(Pb(II))removal is very important but *** main difficulty of blood Pb(II)removal currently lies in the fact that blood Pb(II)is mainly complexed with hemoglobin(Hb)inside the red blood cells(RBCs).Traditional blood Pb(II)removers are mostly passive particles that do not have the motion ability,thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively ***,a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on Fe3O4 nanoparticle modified with meso-2,3-dimercaptosuccinic acid(DMSA)was prepared and a blood Pb(II)removal strategy was further *** the removal process,the nanomotor adsorbent can enter the RBCs,then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of *** the strong coordination of functional groups in DMSA,the nanomotor adsorbent can adsorb Pb(II),and finally be separated from blood by permanent magnetic *** in vivo extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II)in pig models,which may provide innovative ideas for blood heavy metal removal in the future.

关键词： Heavy metal poisoning Blood lead(II)poisoning magnetic nanomotor adsorbent Alternating magnetic field meso-2 3-Dimercaptosuccinic acid

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