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Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging

引用

Bioactive Materials 2023年第1期19卷 538-549页

作者： Xueyang Xiao Hao Cai Qiaorong Huang Bing Wang Xiaoming Wang Qiang Luo Yinggang Li Hu Zhang Qiyong Gong Xuelei Ma Zhongwei Gu Kui Luo Department of Radiology Department of BiotherapyHuaxi MR Research Center(HMRRC)Laboratory of Stem Cell BiologyCancer CenterDepartment of UltrasoundNational Clinical Research Center for GeriatricsFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Functional and Molecular imaging Key Laboratory of Sichuan Province Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu610041China Amgen Bioprocessing Centre Keck Graduate InstituteCA91711USA

Nanoprobes that offer both fluorescence imaging(FI)and magnetic resonance imaging(MRI)can provide supplementary information and hold synergistic ***,synthesis of such dual-modality imaging probes that simultaneously exhibit tunability of functional groups,high stability,great biocompatibility and desired dual-modality imaging results remains *** this study,we used an amphiphilic block polymer from(ethylene glycol)methyl ether methacrylate(OEGMA)and N-(2-hydroxypropyl)methacrylamide(HPMA)derivatives as a carrier to conjugate a MR contrast agent,Gd-DOTA,and a two-photon fluorophore with an aggregation-induced emission(AIE)effect,TPBP,to construct a MR/two-photon fluorescence dual-modality contrast agent,*** of gadolinium in the hydrophilic chain segment of the OEGMA-based carrier resulted in a high r_(1)value for Gd-DOTA-TPBP,revealing a great MR imaging *** contrast agent specifically accumulated in the tumor region,allowing a long enhancement duration for vascular and tumor contrast-enhanced MR ***,coupling TPBP with AIE properties to the hydrophobic chain segment of the carrier not only improved its water solubility and reduced its cytotoxicity,but also significantly enhanced its imaging performance in an aqueous ***-DOTA-TPBP was also demonstrated to act as an excellent fluorescence probe for two-photon-excited bioimaging with higher resolution and greater sensitivity than *** high-resolution,complementary MRI/FI dual-modal images were acquired at both cellular and tissue levels in tumor-bearing mice after application of Gd-DOTA-TPBP,it has great potential in the early phase of disease diagnosis.

关键词： RAFT polymerization Amphiphilic block polymers magnetic resonance/fluorescence dual-modal imaging Tumor/vascular imaging Two-photon AIE fluorescent contrast agent

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