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Promising effect of magliasa, a traditional Iranian formula, on experimental colitis on the basis of biochemical and cellular findings

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World Journal of Gastroenterology 2013年第12期19卷 1901-1911页

作者： Roja Rahimi Amir Baghaei Maryam Baeeri Gholamreza Amin Mohammad Reza Shams-Ardekani Mahnaz Khanavi Mohammad Abdollahi Department of Traditional Pharmacy Tehran University of Medical Sciences Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Department of Pharmacology and Toxicology Tehran University of Medical Sciences Department of Pharmacognosy Tehran University of Medical Sciences

AIM: To investigate the efficacy of magliasa, a traditional Iranian formula, on experimental colitis. METHODS: After botanical authentication of herbal ingredients, formulation of magliasa, quantitative determination of total glucosinolates and total phenolic content, and analysis of the thin layer chromatography profile were performed. Colitis was then induced in male rats by instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in all groups, aside from the Sham *** experimental groups consisted of: the Sham group that received only normal saline; the Mag-50, Mag-100 and Mag-200 groups, which received 50, 100 and 200 mg/kg per day of magliasa, respectively; the control group, which received vehicle water orally; the infliximab group, which received infliximab (5 mg/kg per day, subcutaneously); and the Dexa group, which received dexamethasone (1 mg/kg per day, orally). After completing the treatment period (2 wk), the rats were sacrificed, the colon was removed, its macroscopic and microscopic changes were recorded, and tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1b), total antioxidant capacity, myeloperoxidase (MPO), and lipid peroxidation (LPO) were assessed in colon ***: The mean value of total glucosinolates in one gram of magliasa was 19 ± 1 μmol. The mean value of the total phenolic content was 293.8 ± 17.6 mg gallic acid equivalents per 100 gram of magliasa. Macroscopic scores were significantly decreased in Mag-100 (1.80 ± 0.58, P = 0.019) and Mag-200 (1.20 ± 0.20, P = 0.001) compared to the control group (3.40 ± 0.24), although some inflammation and hyperemia were evident. Treatment of rats by dexamethasone (0.33 ± 0.21, P < 0.001) and infliximab (0.83 ± 0.31, P < 0.001) remarkably attenuated scores where mild hyperemia was observed macroscopically. In comparison to the control group (4.00 ± 0.32), only Mag-200 (1.60 ± 0.40) showed a significant decrease in colonic histopathological scores (P = 0.005). Minimal mucos

关键词： magliasa Traditional Iranian medicine Colitis Neutrophil infiltration Inflammatory cytokines Oxidative stress

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