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Regulation of the macrophage phenotype on Titanium Metal by Surface Modification

Journal of Bionic Engineering 2022年第6期19卷 1625-1636页

作者： Shibing Xiong Xugang Lu Rui Zuo Ping Huang Bangcheng Yang Engineering Research Center in Biomaterials Sichuan UniversityChengdu610064China National Engineering Research Center for Biomaterials Chengdu610064China Sichuan Guojia Biomaterials Co. LtdChengdu610064China Panzhihua University Panzhihua Int Res Inst Vanadium and TitaniumPanzhihua617000SichuanChina

The regulation of macrophage phenotype(M1/M2)is very important for tissue *** macrophage phenotypes could be affected by the physical and chemical parameters of implant *** aim of this study was to investigate the effects of surface modifications of titanium metals on macrophage *** medical pure titanium metals(PT-Ti)subjected to Anodic Oxidation(AO-Ti),Sand Blasting/acid etching(SLA-Ti)and Plasma-sprayed HA coating(HA coating-Ti)were used for regulating the phenotype of *** results showed that the Raw264.7 cells of AO-Ti groups had no obvious pseudopodia and could spread evenly in all *** levels of IL-1βand TNF-α,which belong to pro-inflammatory genes,expressed by the cells on AO-Ti groups were the lowest among all of the modified titanium ***,the levels of IL-10 and TGF-β,which belong to anti-inflammatory genes,expressed on AO-Ti groups were much higher than those on the other ***,the AO-Ti could regulate the expression of SOCS-1 and SOCS-3 to affect the active of NF-κB *** gene expression results of macrophages showed that the AO-Ti was more conductive to inhibit the expression of M1-related genes and promote the expression of M2-related genes in an inflammatory *** AO-Ti was more beneficial to tissue repair than other modified titanium *** results showed that the anodic oxidation is an effective method to regulate the phenotype of macrophages.

关键词： Titanium Dental implant Bionic surface modification Anti-inflammatory macrophage phenotype

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Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching

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Food Science and Human Wellness 2022年第1期11卷 129-142页

作者： Yuyang Sun Jiqing Tang Cui Li Jun Liu Haijie Liu College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China

Innate immunity,particularly macrophages,is critical for intestinal ***,a dietary isothiocyanate from cruciferous vegetables,has been reported to protect against intestinal ***,the role of macrophages in sulforaphane mediated intestinal inflammation and the underlying molecular mechanisms have not been studied *** this study,sulforaphane effectively attenuated dextran sodium sulphate(DSS)induced intestinal inflammation in murine *** note,sulforaphane skewed the switching from classically(M1)to alternatively(M2)activated phenotype both in intestinal and bone marrow-derived macrophages(BMDMs).The expression levels of M1 associated maker genes induced by DSS or lipopolysaccharide(LPS)plus interferon gamma-γ(IFN-γ)were suppressed by sulforaphane while M2 marker gene expression levels were *** resulted in alteration of inflammatory mediators,particularly interleukin-10(IL-10),both in colon tissues and culture medium of ***,IL-10 was found to mediate the sulforaphane induced M2 phenotype switching of BMDMs through the activation of STAT3 *** was confirmed by immunofluorescence analysis with increased number of p-STAT3-positive cells in the colon ***,anti-IL-10 neutralizing antibody significantly interfered M2 phenotyping of BMDMs induced by sulforaphane with reduced STAT3 *** here introduced a potential utilization of sulforaphane for intestinal inflammation treatment with macrophages as the therapeutic targets.

关键词： BMDMs Intestinal inflammation IL-10 macrophage phenotype STAT3 Sulforaphane

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Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes

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Bioactive Materials 2021年第11期6卷 4065-4072页

作者： Yilun Luo Xiaowen Zheng Peiqi Yuan Xingyao Ye Lie Ma MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Due to the critical roles of macrophage in immune response and tissue repair,harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many *** there have developed many advanced platforms with dynamic features for cell manipulation,few studies have designed a dynamic chemical pattern to sequentially polarize macrophage phenotypes and meet the immune requirements at various tissue repair ***,we propose a novel strategy for spatiotemporal manipulation of macrophage phenotypes by a UV-induced dynamic Arg-Gly-Asp(RGD)*** employing a photo-patterning technique and the specific interaction between cyclodextrin(CD)and azobenzene-RGD(Azo-RGD),we prepared a polyethylene glycol-dithiol/polyethylene glycol-norbornene(PEG-SH/PEG-Nor)hydrogel with dynamic RGD-patterned *** irradiation with 365-nm UV light,the homogeneous RGD surface was transformed to the RGD-patterned surface which induced morphological transformation of macrophages from round to elongated and subsequent phenotypic transition from pro-inflammation to *** mechanism of phenotypic polarization induced by RGD pattern was proved to be related to Rho-associated protein kinase 2(ROCK2).Sequential modulation of macrophage phenotypes by the dynamic RGD-patterned surface provides a remote and non-invasive strategy to manipulate immune reactions and achieve optimized healing outcomes.

关键词： Light-responsive Dynamic RGD pattern macrophage phenotype Immune response Tissue repair

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