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Metabolomic profiles in a green alga (Raphidocelis subcapitata) following erythromycin treatment: ABC transporters and energy metabolism

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Journal of Environmental Sciences 2023年第2期124卷 591-601页

作者： Jiezhang Mo Zhihua Ma Shiwei Yan Napo KM Cheung Fangshe Yang Xiunan Yao Jiahua Guo Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi’an 710127China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongKowloonHong KongChina

A recent study showed that erythromycin(ERY)exposure caused hormesis in a model alga(Raphidocelis subcapitata)where the growth was promoted at an environmentally realistic concentration(4μg/L)but inhibited at two higher concentrations(80 and 120μg/L),associated with opposite actions of certain signaling pathways(e.g.,xenobiotic metabolism,DNA replication).However,these transcriptional alterations remain to be investigated and verified at the metabolomic *** study uncovered metabolomic profiles and detailed toxic mechanisms of ERY in *** using *** analysis showed that metabolomic pathways including ABC transporters,fatty acid biosynthesis and purine metabolism were associated with growth promotion in algae treated with 4μg/L *** overcompensation was possibly activated by the low level of ERY in algae where more resources were reallocated to efficiently restore the temporary impairments,ultimately leading to the outperformance of *** contrast,algal growth inhibition in the 80 and 120μg/L ERY treatments was likely attributed to the dysfunction of metabolomic pathways related to ABC transporters,energy metabolism and metabolism of *** from binding of ERY to the 50S subunit of ribosomes to inhibit protein translation as in bacteria,the data presented here indicate that inhibition of protein translation and growth performance of algae by ERY may also result from the suppression of amino acid biosynthesis and aminoacyl-tRNA *** study provides novel insights into the dose-dependent toxicity of ERY on ***.

关键词： Hormesis Metabolome ABC transporters DNA replication Microalgae macrolide antibiotic

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