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Real-time SERS monitoring anticancer drug release along with SERS/mr imaging for pH-sensitive chemo-phototherapy

Acta Pharmaceutica Sinica B 2023年第10期13卷 1303-1317页

作者： Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun The Second Clinical Medical College(Shenzhen People’s Hospital) College of PharmacyJinan UniversityGuangzhou510632China Department of Chemistry Jinan UniversityGuangzhou 510632China Department of Physics the University of Texas at ArlingtonArlingtonTX 76019USA

In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy.In this study,a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy(SERS).The Fe3O4@Au@Ag nanoparticles(NPs)deposited graphene oxide(GO)nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid(4-MPBA)to form SERS probes(GO-Fe3O4@Au@Ag-MPBA).Furthermore,doxorubicin(DOX)is attached to SERS probes through a pH-responsive linker boronic ester(GO-Fe3O4@Au@Ag-MPBA-DOX),accompanying the 4-MPBA signal change in SERS.After the entry into tumor,the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal.Thus,the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra.Additionally,the strong T2 magnetic resonance(mr)signal and NIR photothermal transduction efficiency of the nanocomposites make it available for mr imaging and photothermal therapy(PTT).Altogether,this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting,pH-sensitive drug release,SERS-traceable detection and mr imaging,endowing it great potential for SERS/mr imaging-guided efficient chemo-phototherapy on cancer treatment.

关键词： Surface-enhanced Raman spectroscopyp H-sensitive nanoparticles Real-time monitoring Chemo-phototherapy Drug delivery systems Anti-cancer nanotechnology Two-dimensional matrix Cancer cell targeting mr imaging

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mr imaging ASSESSMENT OF IRREGULAR SHRINKAGE OF TUMOR MORPHOLOGY AND VOLUME IN CERVICAL CANCER DURING RADIATION THERAPY

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Chinese Journal of Cancer Research 2004年第2期16卷 137-141,149页

作者：李文彬李明华崔雪娥 WilliamT.C.Yuh NinaA.Mayr Department of Radiology Affiliated Sixth People'S Hospital Shanghai Jiaotong University Shanghai 200233 China Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA Radiation Oncology Center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

To study the clinical significance of the morphological and volume changes in cervical cancer during an ongoing course of radiation therapy (RT) using mr imaging. Methods: Serial mr imaging examinations were performed in 60 advanced cervical cancer patients. mr imaging was obtained at the start of RT, at 20-25 Gy (2-2.5 weeks of RT), at 45-50 Gy (4-5 weeks of RT), and 1-2 month post-RT. Tumor morphology was classified qualitatively as well-defined (round/oval with a well-demarcated smooth margin) vs. lobulated vs. irregular and tumor volume was assessed in each serial mr examination independently by ROI volumetry and diameter volumetry. ROI volumetry was traced on the computer workstation with a trackball in each sagittal T2-weighted image and calculated by the summation of all tumor areas in each slice and multiplication by the slice profile. Diameter volumetry was to measure the largest three orthogonal tumor diameters in each orthogonal measurement plane and calculate as an ellipsoid formula (V=d1 x d2 x d3 x p/6). Serial tumor volume was compared between the two measurement methods. Results: The proportion of lobulated and irregular tumors increased early during RT and declined lately post-RT (68% pre-RT, 80% at 2-2.5 weeks of RT, 72% at 4-5 weeks of RT, 33% post-RT). Accordingly, ROI volumetry and diameter volumetry correlated well pre-RT (r1=0.89) and post-RT (r4=0.80), but poorly during RT (r2 = 0.17 at 2-2.5 weeks of RT, r3 = 0.69 at 4-5 weeks of RT). Conclusions: Cervical cancers regress in a non-uniform fashion during RT and undergo increasingly irregular shrinkage. Measurement with ROI volumetry techniques, which can optimally measure irregular volumes, provides better assessment of radiation response during treatment than diameter volumetry.

关键词： Cervical cancer mr imaging Tumor volume Radiation therapy Tumor regression

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CT and mrI diagnosis of hepatic epithelioid hemangioendothelioma

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 154-158页

作者： Lin, Jiang Ji, Yuan Fudan Univ Shanghai Zhongshan Hosp Dept Radiol Shanghai 200032 Peoples R China Fudan Univ Shanghai Zhongshan Hosp Dept Pathol Shanghai 200032 Peoples R China

BACKGROUND: Hepatic epithelioid hemangioendothelioma (EHE) is a rare, low-grade malignant vascular tumor. Although its unusual imaging and pathologic findings are being recognized with increasing frequency, diagnosis is still difficult. This study aimed to analyze the CT and mrI features of hepatic EHE with a pathological study in order to improve the diagnostic accuracy and knowledge of this disease in daily practice. METHODS: Nine patients with hepatic EHE confirmed pathologically underwent plain and dynamic contrast-enhanced multi-detector row CT examination. Of these patients, four underwent additional mrI (plain Ti-weighted imaging (T1WI), T2-weighted imaging (T2WI), and dynamic contrast-enhanced scanning) and one had selective hepatic arteriography. The imaging findings were reviewed retrospectively together with the pathological results. RESULTS: A total of 79 lesions, ranging from 3.0 to 44.6 mm in maximum diameter, with an average of 16.8 +/- 7.1 mm, were found in various segments of the liver. Thirty of the 79 lesions grew adjacent to the hepatic capsule. In the 4 patients receiving mrI, 39 lesions were found with low signal intensity on unenhanced T1WI and intermediate to high signal intensity on T2WI. The 'capsular retraction' sign was found in all the 4 patients. Nine of the 39 lesions showed the 'halo' sign after contrast enhancement on mrI. Of the 79 lesions (hypodense nodules) in the 9 patients shown by unenhanced plain CT, 26 were confluent. Calcification was found in 2 patients and the 'capsular retraction' sign in 7. Thirty-eight of the 79 lesions demonstrated the 'halo' sign after contrast enhancement on CT, and this sign was more clearly demonstrated in the portal venous phase. In one patient, selective hepatic arteriography showed patchy stain in the peripheral liver parenchyma with small vessels around them. Histology in all patients revealed proliferation of abnormal fibrous tissue and vessel-like structures scattered with irregular epithelioid cells having a signet ring-like structure. Im

关键词： liver neoplasm epithelioid hemangioendothelioma computed tomography mr imaging

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mrI shows clodronate-liposomes attenuating liver injury in rats with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 192-200页

作者： Zhang, Jian-Xin Dang, Sheng-Chun Zhang, Yong Sha, Xin Zhang, Li-Rong Wei, Chuan-She Chen, Min Jiang, De-Li Jiangsu Univ Affiliated Hosp Dept Gen Surg Zhenjiang 212001 Peoples R China Jiangsu Univ Affiliated Hosp Dept MRI Zhenjiang 212001 Peoples R China Jiangsu Univ Sch Chem & Chem Engn Zhenjiang 212013 Peoples R China

BACKGROUND: Studies have revealed that macrophages play an important role in the development of severe acute pancreatitis (SAP). Activated macrophages can lead to a systemic inflammatory response, induce lipid peroxidation, impair membrane structure, result in injury to the liver and the other extrahepatic organs, and eventually result in multiple organ dysfunction syndrome by promoting excessive secretion of cytokines. Liver injury can further aggravate the systemic inflammatory response and increase mortality by affecting the metabolism of toxins and the release of excessive inflammatory mediators. Clodronate is a synthetic bisphosphonate, which is often used for treating bone changes caused by osteoporosis and other factors. In the current study, we created liposomes containing superparamagnetic iron oxide particles (SPIOs) for macrophage labeling and magnetic resonance imaging, using a novel method that can bind the clodronate to induce apoptosis and deplete macrophages. METHODS: Superparamagnetic Fe(3)O(4) nanoparticles were prepared by chemical coprecipitation. SPIO-containing liposomes and SPIO-clodronate-containing liposomes were prepared by the thin film method. SAP models were prepared by injection of sodium taurocholate (2 ml/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group, a SAP plus SPIO-liposome group, and a SAP plus SPIO-clodronate-containing group. Two and six hours after SAP models were available, T2-weighted mrI scans (in the same plane) of the livers of rats in each group were performed. At the end of the scans, 2 ml of blood was taken from the superior mesenteric vein to measure the levels of serum amylase, ALT, AST, TNF-alpha, and IL-6. Pathological changes in the liver and pancreas were assessed. RESULTS: Transmission electron microscopy showed that the liposomes had a uniform size. No pathological changes in the pancreata of rats in the control group were noted. The pathological changes in the pancreata and livers of

关键词： pancreatitis, acute clodronate disodium liver injury mr imaging macrophage

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Magnetic resonance imaging based volumetry:a primary approach to unravelling the brain

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Progress in Natural Science:Materials International 2007年第7期17卷 751-760页

作者： Huang Xiaoqi~(1,2) LüSu~1 Li Dongming~1 Gong Qiyong~(1,3**) (1.Huaxi mr Research Centre(HmrRC),and Department of Radiology,West China Hospital/West China School of Medicine,Chengdu 610041,China 2.Department of Psychiatry,West China Hospital/West China School of Medicine,Chengdu 610041,China 3.Division of Medical imaging,Faculty of Medicine,University of Liverpool,United Kingdom) Huaxi mr Research Centre (HmrRC) Department of Radiology West China Hospital/West China School of Medicine Chengdu 610041 China Department of Psychiatry West China Hospital/West China School of Medicine Chengdu 610041 China Division of Medical imaging Faculty of Medicine University of Liverpool United Kingdom United Kingdom

Magnetic resonance(mr)imaging based volumetry is recognized as an important technique for studying the brain.In this review,two principle volumetric methods using high resolution mr images were introduced,namely the Cavalieri method and the voxel based morphometry(VBM).The Cavalieri method represents a manual technique that allows the volume of brain structures to be estimated efficiently with no systematic error or sampling bias,whereby the VBM represents an automated image analysis which involves the use of statistical parametric mapping of the mr imaging data.Both methods have been refined and applied extensively in recent neuro- science research.The present paper aims to describe the development of methodologies and also to update the knowledge of their applica- tions in studying the normal and diseased brain.

关键词： mr imaging Cavalieri method voxel-based morphometry brain volumetry

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Dual-targeted nanoformulation with Janus structure for synergistic enhancement of sonodynamic therapy and chemotherapy

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Chinese Chemical Letters 2023年第7期34卷 454-460页

作者： Zhifang Wang Man Wang Yanrong Qian Yulin Xie Qianqian Sun Minghong Gao Chunxia Li Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China

The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is an effective solution.Here,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for delivery.The system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of HA.Ultra-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo metabolism.Under ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)production.Meanwhile,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial respiration.LND could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of apoptosis.Furthermore,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (mr)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and therapy.In conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.

关键词： Ultra-small Janus structure Mitochondrial targeting CD44 targeting Synergistic therapy mr imaging

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Nanogels as Contrast Agents for Molecular imaging

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Chinese Journal of Chemistry 2016年第6期34卷 547-557页

作者： Jianzhi Zhu Wenjie Sun Xiangyang Shi College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 China

Nanogels （NGs） as soft nanosized materials have gained a variety of interests in biomedical fields. The versatile NG scaffolds with 3-dimensional spherical shape, high loading efficiency, tunable surface functionalization, and excellent biocompatibility afford their uses as carrier to load mono- or multi-mode molecular imaging contrast agents （CAs）. This review summarizes the synthesis routes and applications of NGs as CAs for molecular imaging applications including magnetic resonance （mr）, computed tomography （CT）, radionuclide, optical, and dual/mul- ti-modality imaging.

关键词： nanogels contrast agents mr imaging CT imaging radionuclide imaging optical imaging dual/multi-modality imaging

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A Modified Fuzzy C-Means for Bias Field Estimation and Segmentation of Brain mr Image 25th

A Modified Fuzzy C-Means for Bias Field Estimation and Segme...

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第25届中国控制与决策会议

作者： Zhang Shi She Lihuang Lu Li Zhong Hua Northeastern University

ISBN: (纸本)9781467355339

Fuzzy C-means clustering （FCM） algorithm is good at solving the ambiguities and uncertainties in the image, and the modified FCM has been widely used in solving the intensity inhomogeneity problem. Bias-corrected FCM （BCFCM） is very useful for noise and intensity inhomogeneity image segmentation, but it can’t estimate accurately the pixels on the boundary especially in the regions with heavy level of intensity inhomogeneous. In this paper, we present a novel algorithm for brain magnetic resonance imaging （mrI） Image segmentation and intensity inhomogeneity estimation based on BCFCM. The proposed algorithm introduces the global intensity information into the algorithm BCFCM, for the smooth bias field estimation and more accurate segmentations. The proposed method has been successfully applied to mr brain images, and experiment results show that this method is superior to FCM, BCFCM and some other approaches.

关键词： Bias field Fuzzy C-means clustering mage segmentation Global information mr imaging

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The Usefulness of Magnetic Resonance imaging in the Preoperative Study and Postoperative Control in the Laparoscopic Treatment of the Incisional Hernia

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Surgical Science 2015年第8期6卷 376-382页

作者： J.C.Martín del Olmo Luis García-Vallejo Jose Nunez Gestal Pablo Concheiro Coello Francisco Blanco Antona Miguel Toledano Trincado Javier Sanchez Gonzalez M.Luz Martín Esteban L.Colao Carlos Vaquero Puerta Miguel Carbajo Surgery Department Medina del Campo HospitalValladolidSpain Surgery Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Radiology Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Department of General and Digestive Surgery Medina del Campo HospitalValladolidSpain Surgery Department University of ValladolidValladolidSpain CEOAD ValladolidSpain

Background and Objectives: The aim of this study is to evaluate the usefulness of Magnetic Resonance imaging (mrI) for planning surgery and postoperative control of complex cases of abdominal wall hernia. Methods: Included in a prospective data base with more than 350 patients treated in two centers, a prospective study over ten patients with complex incisional hernias was designed. In all cases, preoperative diagnosis study and postoperative imaging control by mr imaging were established. In the early and late follow-up controls, local and general complications were specifically noted and studied by mrI in each case. Results: The preoperative mrI was effective method for an adequate understanding of the defects and hernia sack content. In the postoperative control, the mrI was useful in the follow-up of the mesh integration, detection of complications and diagnosis of the relapsing. Conclusion: In our experience the mrI test is specially recommended in the preoperative workup of complex cases of incisional hernia.

关键词： Incisional Hernia mr imaging Laparoscopic Eventroplasty

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Acinic cell carcinoma of the parotid gland:mr features

Acinic cell carcinoma of the parotid gland:MR features

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第10次全国口腔颌面医学影像学专题研讨会暨国家级口腔颌...

作者： Shi Huimin,Wang Shaoying Department of Radiology,Ninth People’s Hospital,School of Medicine,Shanghai Jiao Tong University,639 Zhi Zao Ju Road,Shanghai 200011,China

Purpose:To evaluate the diagnostic value of mr imaging feature and conventional contrast -enhanced mr imaging appearance in acinic cell carcinoma of the parotid gland. Methods:We retrospectively reviewed pre- and post... 详细信息

关键词： Acinic cell adenocarcinomas mr imaging parotid gland

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