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Prevention and control strategies for antibiotic resistance: from species to community level

SOIL ECOLOGY LETTERS 2024年第3期6卷 230222-230222页

作者： Wang, Yan-Zi Li, Hu Chen, Qing-Lin Pan, Ting Zhu, Yong-Guan Springael, Dirk Su, Jian-Qiang Chinese Acad Sci Inst Urban Environm Key Lab Urban Environm & Hlth Ningbo Observat & Res Stn Xiamen 361021 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chinese Acad Sci Res Ctr Ecoenvironm Sci State Key Lab Urban & Reg Ecol Beijing 100085 Peoples R China Katholieke Univ Leuven Div Soil & Water Management Box 2459Kasteelpark Arenberg 20 B-3001 Heverlee Belgium

ARGs and ARB in typical environments which exposed to antibiotics are ***- and photosensitizer-related technology can clear specific ARGs or ***-Cas- and phage-related technology can eliminate particular ARGs or *** combination can be used to eliminate microbial ***-specific technology can eradicate most types of ARGs or ARB in one *** resistance genes (ARGs) and antibiotic resistant bacteria (ARB) in the environment pose serious threats to environmental security and public health. There is an urgent need for methods to specifically and effectively control environmental pollution or pathogen infection associated with ARGs and ARB. This review aims to provide an overview of methods abating the prevalence and spread of ARGs and ARB from species to community level. At the species level, species-specific technologies, such as nanoparticle-, photosensitizer-, CRISPR-Cas-, and phage-related technology can be utilized to clear a particular class of ARGs or ARB, and in combination with low-dose antibiotics, a higher removal efficiency can be achieved. Moreover, the combination of antibiotics can be used to reverse microbial resistance and treat recurrent antibiotic resistant pathogen infections. At the community level, community-specific strategies, such as biochar, hyperthermophilic compost, and fecal microbiota transplantation can eradicate most types of ARGs or ARB in one shot, reducing the probability of resistance development. Though some progress has been made to eliminate ARGs and ARB in disease treatment or decontamination scenarios, further research is still needed to elucidate their mechanisms of action and scopes of application, and efforts should be made to explore novel strategies to counter the prevalence of antibiotic resistance.

关键词： antibiotic resistance genes antibiotic resistant bacteria treatment strategy disinfection FECAL MICROBIOTA TRANSPLANTATION PHOTODYNAMIC THERAPY WATER-TREATMENT POLYVALENT BACTERIOPHAGE COMBINATION THERAPIES molecular-mechanisms PATHOGENIC BACTERIA HORIZONTAL TRANSFER BIOCHAR AMENDMENT ESCHERICHIA-COLI

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Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis： a new antibiotic resistance drug target

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Protein & Cell 2018年第11期9卷 971-975页

作者： Qingqing Zhang Huijuan Liu Xiang Liu Dunquan Jiang Bingjie Zhang Hongliang Tian Cheng Yang Luke W. Guddat Haitao Yang Kaixia Mi Zihe Rao College of Life Sciences Nankai University Tianjin 300071 China College of Pharmacy Nankai University Tianjin 300071 China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing100101 China School of Life Sciences Tianjin University Tianjin 300072 China School of Chemistry and molecular Biosciences The University ofQueensland Brisbane QLD 4072 Australia Laboratory of Structural Biology School of Medicine TsinghuaUniversity Beijing 100084 China Tianjin International Joint Academy of Biotechnology & Medicine Tianjin 300457 China

Dear Editor The prevalence of multidrug-resistant Mycobacterium tuberculosis （M. tuberculosis） is an increasing problem worldwide （Zumla et al., 2013; Dong et al., 2015）. According to a 2014 World Health Organization （WHO） report, 480,000 individuals world-wide .developed multidrug-resistant tuber- culosis （MDR-TB） and more than 100 countries have cases of extensively drug-resistant tuberculosis （XDR-TB）. Com- pared with drug-susceptible TB, MDR-TB and XDR-TB require prolonged therapeutic treatment with a combination of a number of second-line drugs （Chen et al., 2013）. For patients where TB remains persistent despite prolonged therapy with second-line TB drugs, the add-on agents including bedaquiline and delamanid are recommended for salvage therapy （GUnther, 2014; WHO, 2014; Shim and Jo, 2013）.

关键词： molecular-mechanisms ABC

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