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Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer

World Journal of Critical Care Medicine 2013年第4期2卷 48-55页

作者： Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu Department of Surgery Kurume University School of Medicine Kurume Fukuoka 830-0011 Japan

AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line mkn-45 compared with the high potential peritoneal dissemination gastric cancer cell line mkn-45 p. METHODS: The supernatant of culture medium of mkn-45 cells or mkn-45 p cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for mkn-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer.

关键词： Gastric cancer peritoneal metastasis Vascular endothelial growth factor mkn-45p Bevacizumab

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