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Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with PCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo ***,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based ***,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment *** primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat *** addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical *** to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D *** bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in *** the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy *** component analysis(PCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D *** study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium Implants Bone fracture mineralization Systemic modulation Principal component analysis.

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MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts

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Genes & Diseases 2024年第5期11卷 9-12页

作者： Wuxia Qiu Xiao Lin Shaoqing Yang Zhihao Chen Kewen Zhang Chaofei Yang Yu Li Zhiping Miao Xiaoni Deng Xiaohong Duan Airong Qian Lab for Bone Metabolism Xi’an Key Laboratory of Special Medicine and Health EngineeringKey Lab for Space Biosciences and BiotechnologyResearch Center for Special Medicine and Health Systems EngineeringNPU-UAB Joint Laboratory for Bone MetabolismSchool of Life SciencesNorthwestern Polytechnical UniversityXi’anShaanxi 710072China State Key Laboratory of Military Stomatology National Clinical Research Center for Oral DiseasesDepartment of Oral BiologyClinic of Oral Rare and Genetic DiseasesSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China School of Chemical Engineering Sichuan University of Science&EngineeringZigongSichuan 643000China Research&Development Institute of Northwestern Polytechnical University in Shenzhen ShenzhenGuangdong 518063China Puyang Institute of Technology Henan UniversityPuyangHenan 457000China

Tooth mineralization is a ubiquitous and tightly regulated process involving complicated interactions between dental epithelium and *** molecules in tooth mineralization remain poorly *** actin cross-linking factor 1(MACF1)is a spectraplakin protein that plays pivotal roles in the brain,muscle,lung,and bone developmental process.^(1-3) To study the specific functions of MACF1 in bone formation,we established Macf1 conditional knockout mice using the Cre-LoxP system driven by Osxterix promoter(Osx-Cre;Macf1^(f/f)).^(2) Not surprisingly,Osx-Cre;Macf1^(f/f) mice displayed the phenotypes of delayed ossification and decreased bone ***,the OsxCre;Macf1^(f/f) mice unexpectedly showed a white and opaque appearance of incisors,contrary to the normal yellowbrown and transparent *** Osxterix is expressed in dental mesenchyme during tooth development,the abnormal tooth appearance might imply a new function of MACF1 in odontoblasts,or even ***,the present study aimed to investigate the role of MACF1 during tooth development.

关键词： mineralization linking transparent

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A New Discovery of mineralization as Subseafloor Hydrothermal Replacement in the Duddar Super-Large SEDEX Lead-Zinc Deposit in Pakistan

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Journal of Earth Science 2024年第3期35卷 1075-1078页

作者： Huishan Zhang Yucai Song Jianing Sun Jun Hong Yasir Shaheen Khalil Yanguang Li Haidi Zhang Zhihua Wang MNR Key Laboratory for the Study of Focused Magmatism and Giant Ore Deposits Xi’an Center of Geological SurveyChina Geological SurveyXi’an 710054China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Chengdu Center of Geological Survey China Geological SurveyChengdu 610081China China Huaye Group Co. LtdBeijing 100037China Geological Survey of Pakistan Islamabad 44000Pakistan

0 INTRODUCTION Sedimentary exhalative(SEDEX)lead-zinc deposit was traditionally considered as a result of submarine hydrothermal exhalation,including exhalative plume and brine pool models(Izanloo et al.,2022;Spinks et al.,2021;Maghfouri et al.,2020;Sangster,2020,2018;Huang et al.,2019;Rajabi et al.,2015;Goodfellow and Lydon,2007;Large et al.,2005,2001;Peng et al.,2000;Goodfellow et al.,1993;Figures 1a,1b).However,recognition of mineralization as subseafloor hydrothermal replacement in a few SEDEX deposits has challenged the traditional consideration(Magnall et al.,2023,2021,2020a,b;Hayward et al.,2021;Figure 1c).Researchers come to believe that subseafloor replacement rather than submarine exhalation is a dominant process for SEDEX mineralization,but this needs to be examined through more case studies.

关键词： submarine mineralization seafloor

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Multivariate Statistical Analysis of Dominating Groundwater mineralization and Hydrochemical Evolution in Gao, Northern Mali

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Journal of Earth Science 2024年第5期35卷 1692-1703页

作者： Adiaratou Traore Xumei Mao Alhousseyni Traore Yahaya Yakubu Aboubacar Modibo Sidibe School of Environmental Studies China University of Geosciences College of Construction Engineering Jilin University

Population growth and expanding urbanization have caused persistent shortages and contamination of groundwater resources in Mali, Africa. The increase in groundwater salinity makes it more difficult for residents to obtain drinking water, it is necessary to clarify the causes and control factors of groundwater mineralization in Gao region, northern Mali. Based on the analysis of the hydrochemical composition of groundwater in 24 boreholes, Piper and Sch?eller diagrams, principal component analysis(PCA) and hierarchical cluster analysis(HCA) are used to carry out multivariate statistical analysis on the main ions. The results show that the groundwater samples are weakly alkaline, with p H values ranging from 5.83 to 8.40, and the average values of boreholes are 7.50, respectively. The average electrical conductivity(EC) value is 354.4(μS/cm), and the extreme value is between 124.0 and 1 247(μS/cm). Water is usually mineralized and presents nine types of water phase. The three principal components explain 84.42% of the total variance for 13 parameters. The factor F1(58.85%), the factor F2(16.88%) and the factor F3(8.69%) present for the majority of the total data set. In addition, multivariate statistical analysis confirmed the genetic relationship among aquifers and identified three main clusters. Clustering related to groundwater mineralization(F1), clustering related to oxide reduction and iron enrichment(F2), and clustering of groundwater pollution caused by nitrate and magnesium(F3). We found that agriculture, weathering activities and dissolution of geological materials promote the mineralization of groundwater. Groundwater quality in the Gao region is becoming less and less potable because of increasing salinity.

关键词： hydrochemical composition multivariate statistical analysis mineralization hydro-chemical evolution Gao northern Mali hydrogeology

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Hydrochemistry of Groundwater in the Rice Cultivation Area of Maga: Analysis of the mineralization Process

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Journal of Geoscience and Environment Protection 2024年第9期12卷 370-387页

作者： Emmanuel Aguiza Abaï Hugues Pahimi Prosper Samba Koukouare Guillaume Ewodo Mboudou Auguste Ombolo Department of Industrial Security Quality and Environment National Advanced School of Mines and Petroleum Industries University of Maroua Kaele Cameroon School of Chemical Engineering and Mineral Industries University of Ngaoundere Ngaoundere Cameroon Department of Hydrocarbons Exploitation Mao National Higher Petroleum Institute NDjamena Chad Department of Hydraulics and Water Management National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon Department of Rural Engineering Higher Institute of Agriculture Forestry Water and Environment University of Ebolowa Ebolowa Cameroon

The use of groundwater for drinking water supply to the population is increasingly practiced in the rice cultivation area of Maga. However, there is a lack of knowledge about the hydrochemical characteristics of this water due to a lack of quality control. This study aims to contribute to the understanding of mineralization processes in order to establish the hydrochemical profile of the water in the area. The methodological approach consisted of collecting fifteen water samples from wells and boreholes during six campaigns for physicochemical analysis, and studying them through methods of interpreting hydrochemical data. The analysis results show that these waters are moderately mineralized. The water facies are mainly of the bicarbonate sodium and potassium type, as well as the bicarbonate calcium and magnesium type. Calculation of saturation indices demonstrates that evaporite minerals show lower degrees of saturation than carbonate minerals, with gypsum, anhydrite, and halite being in a highly undersaturated state. The mineralization of groundwater originates from the dissolution of surrounding rocks on the one hand, and anthropogenic activities involving exchanges between alkalis (Na+ and K+) in the aquifer and alkaline earth (Ca2+ and Mg2+), resulting in the fixation of alkaline earth and the dissolution of alkalis.

关键词： Hydrochemistry mineralization Groundwater Maga

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mineralization of aqueous pentachlorophenolate by anodic contact glow discharge electrolysis

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Journal of Environmental Sciences 2011年第6期23卷 1044-1049页

作者： Haiming Yang Meguru Tezuka Graduate School of Engineering Saitama Institute of Technology Fusaiji Fukaya Saitama 369-0293 Japan School of Chemical Engineering University of Science and Technology Liaoning Anshan 114051 China

Exhaustive mineralization of pentachlorophenolate ion（PCP） in phosphate buffer was carried out using anodic contact glow discharge electrolysis（CGDE）,in which plasma was sustained between the electrolyte and *** CGDE,PCP degraded *** amount of total organic carbon decreased significantly,indicating the eventual conversion of the carbon atoms of benzene nucleus to inorganic ***,chlorine atoms in PCP were liberated as chloride *** a primary intermediate product,2,3,5,6tetrachloro-1,4-benzoquinone was detected,and oxalate and formate as byproducts were also *** was revealed that disappearance of PCP obeyed first-order *** reaction rate was generally unaffected by both O2 and inert gases in the cell,although it decreased by raising initial pH of *** addition,a plausible reaction pathway involving hydroxyl radical was proposed.

关键词： pentachlorophenol mineralization contact glow discharge electrolysis first-order rate law

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mineralization episode of porphyry copper deposits in the Jinshajiang-Red River mineralization belt: Re-Os dating

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Science China Earth Sciences 2005年第2期48卷 192-198页

作者： WANG Denghong, QU Wenjun, LI Zhiwei, YIN Hanlong4 & CHEN Yuchuan Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China National Center of Rock and Mineral Analysis, Chinese Academy of Geological Sciences, Beijing 100037, China Resource Assessment Center of Yunnan, Kunming 650011, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Chinese Academy of Geological Sciences, Beijing 100037, China Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing China National Center of Rock and Mineral Analysis Chinese Academy of Geological Sciences Beijing China Resource Assessment Center of Yunnan Kunming China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China Chinese Academy of Geological Sciences Beijing China

Re-Os isotopic dating for the molybdenites from the porphyry copper deposits of the Jinshajiang-Red River mineralization belt in Yunnan Province yields isochron ages of 33.9±1.1 Ma for the Machangqing deposit and 34.4±0.5 Ma for the Tongchang deposit. This result shows that both the Machangqing and the Tongchang porphyry Cu-Mo deposits from two different ore-fields formed simultaneously. This new data and the published Re-Os model ages of molybdenite (35.4 Ma, 35.9 Ma, 36.2 Ma) of the Yulong porphyry copper deposit in Tibet, which is located in the same Jinshajiang-Red River mineralization belt as the Machangqing deposit and the Tongchang deposit, suggest that these three Cenozoic porphyry copper deposits in the Jinshajiang-Red River mineralization belt were contemporary for their mineralization episode. That is to say, even their present locality is far away and nearly iso-distantly distributed, these three porphyry Cu(Mo) deposits belong to the same mineralization episode at the end of Eocene.

关键词： Re-Os isotopic dating, porphyry Cu deposits, Cenozoic, mineralization episode.

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mineralization of Hydroxyapatite Regulated by Recombinant Human-like Collagen

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 41-43页

作者：翟勇崔福斋 Biomaterials Laboratory Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

We reported recombinant human-like type I collagen inducing growth of hydroxyapatite crystals in vitro in the form of self-assembly of nano-fibrils of mineralized collagen resembling extracellular matrix, which obey the same rules, but is superior to the collagen derived from animal tissues because the latter may carry diseases of animals and cause immunological reactions. The mineralized collagen fibrils aligned parallel to each other to form mineralized collagen fibers. Hydroxyapatite nanocrystals grew on the surface of these collagen fibrils with the c-axis of nanocrystals of HA orienting along the longitudinal axis of the fibrils.

关键词： mineralization collagen recombinant

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mineralization of the Liwu large-scale stratiform copper deposits in Sichuan Province, China: Constraints from fluid inclusions

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China Geology 2023年第2期6卷 252-268页

作者： Hua-yun Yuan Qing Zhou Yuan-bao Song Wei Zhang Hui-hua Zhang Tong-zhu Li Tao Yin Chang-nan Wang Gao-lin Tang Evaluation and Utilization of Strategic Rare Metals and Rare Earth Resource Key Laboratory of Sichuan Province Sichuan Geological SurveyChengdu 610081China Chengdu Center China Geological SurveyMinistry of Natural ResourcesChengdu 610081China Sichuan Liwu Copper Mining Company Ganzi 626200China

The Liwu stratiform copper deposit is located in the northwestern Jianglang dome,western *** studies mainly focus on the genetic type and mineralization of this *** fluid inclusion characteristics of metallogenic period quartz veins were studied to reveal the ore-forming fluid *** Raman analysis indicates that the ore-forming fluids is a H_(2)O-NaCl-CH_(4)(-CO_(2))*** inclusions microthermometry shows a homogenization temperature of 181-375°C and a salinity of 5.26%-16.99%for the disseminated-banded Cu-Zn mineralization;but a homogenization temperature of 142-343°C and a salinity of 5.41%-21.19%for the massive-veined Cu-Zn *** features suggest a medium-high temperature and a medium salinity for the ore-forming fluids.H-O isotopic data indicates that the ore-forming fluids were mainly from the metamorphic and magmatic water,plus minor formation *** sulfur isotopic data indicates that sulfur was mainly derived from the formation and magmatic *** of the disseminated-banded mineralization was mainly correlated with fluid mixing and water-rock reaction;whereas that of the massive-veined mineralization was mainly correlated with fluid *** genetic type of the deposit is a medium-high temperature hydrothermal deposit related to magmatism and controlled by shear *** study is beneficial to understand the stratiform copper deposit.

关键词： Stratiform copper deposit mineralization Fluid inclusion H-O isotopes Hydrothermal deposit Dome structure Middle Proterozoic metamorphic rock Mineral exploration engineering Sichuan Province

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Surface Treatment and Biomimetic mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D,L-lactide)

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Chinese Journal of Polymer Science 2017年第7期35卷 837-845页

作者： Le-yuan Song 蒋妮甘志华 State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate-g-poly（D,L-lactide）（CG-g- PDLLA） composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid （1.5 SBF） solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG-g- PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.

关键词： Calcium gluconate Poly(D,L-lactide) mineralization Hydroxyapatite Porous microspheres

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