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Osteocyte morphology and orientation in relation to strain in the jaw bone

International Journal of Oral Science 2018年第1期10卷 36-43页

作者： Vivian Wu René F. M. van Oers Engelbert A. J. M. Schulten Marco No Helder Rommel G. Bacabac Jenneke Klein-Nulend Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands Department of Dental Materials Science Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands Department of Oral and Maxillofacial Surgery VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences Amsterdam The Netherlands Department of Physics Medical Biophysics Group University of San Carlos Cebu City Philippines

Bone mass is important for dental implant success and is regulated by mechanoresponsive osteocytes. We aimed to investigate the relationship between the levels and orientation of tensile strain and morphology and orientation of osteocytes at different dental implant positions in the maxillary bone. Bone biopsies were retrieved from eight patients who underwent maxillary sinus-floor elevation with β-tricalcium phosphate prior to implant placement. Gap versus free-ending locations were compared using 1) a three-dimensional finite-element model of the maxilla to predict the tensile strain magnitude and direction and 2) histology and histomorphometric analyses. The finite-element model predicted larger, differently directed tensile strains in the gap versus freeending locations. The mean percentage of mineralised residual native-tissue volume, osteocyte number(mean ± standard deviations:97 ± 40/region-of-interest), and osteocyte shape(90% elongated,10% round) were similar for both locations. However, the osteocyte surface area was 1.5-times larger in the gap than in the free-ending locations, and the elongated osteocytes in these locations were more cranially caudally oriented. In conclusion, significant differences in the osteocyte surface area and orientation seem to exist locally in the maxillary bone, which may be related to the tensile strain magnitude and orientation. This might reflect local differences in the osteocyte mechanosensitivity and bone quality, suggesting differences in dental implant success based on the location in the maxilla.

关键词： SINUS FLOOR ELEVATION mineral density MAXILLARY HISTOMORPHOMETRY TOMOGRAPHY IMPLANTS SPINE

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Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration

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International Journal of Oral Science 2018年第1期10卷 50-64页

作者： Aya Shibamoto Toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki Division of Advanced Prosthetic Dentistry Tohoku University Graduate School of Dentistry Department of Oral Health Sciences Prosthetic DentistryBIOMAT-BiomaterialsKatholieke Universiteit Leuven

The objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by *** trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

关键词： WHOLE-BODY VIBRATION ORAL BISPHOSPHONATES LOW-MAGNITUDE POSTMENOPAUSAL WOMEN mineral density MECHANICAL SIGNALS TITANIUM IMPLANTS DENTAL IMPLANTS TERIPARATIDE OSTEOPOROSIS

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Primary osteoporosis in postmenopausal women

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Chronic Diseases and Translational Medicine 2015年第1期1卷 -页

作者： Meng-Xia Ji Qi Yu Department of 0bstetrics and Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

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