检索结果-南通市图书馆

Pathologic features and clinical outcome of central neurocytoma:analysis of 15 cases

Chinese Journal of Cancer Research 2012年第4期24卷 284-290页

作者： Yu Li Xiu-Feng Ye Guo Qian Yu Yin Qian-Guan Pan Institute of Neuroscience Department of PathologyChongqing Medical University

Objective： To get better recognition of central neurocytoma and diminish misdiagnosis. Methods： A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed. Results： There were 8 males and 7 females aged 10-64 years （median 32.93 years）. The most common presenting symptoms were those related to increased intracranial pressure （ICP）, including headache （100%）, papilledema （93 %） and vomiting （80%）. All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix （neuropil）. Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin （15/15）, neuron specific enolase （12/15） and glial fibrillary acidic protein （GFAP）（3/15）. mib-1 proliferation index ranged from 0.8- 12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available. Conclusions： Central neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.

关键词： Central neurocytoma histopathology immunohistochemistry proliferation mib-1 labeling index

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：