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Genetic polymorphism of mcp-1-2518,IL-8-251 and susceptibility to acute pancreatitis:A pilot study in population of Suzhou,China

引用

World Journal of Gastroenterology 2008年第37期14卷 5744-5748页

作者： Wei-Chang Chen Jin-Shan Nie Department of Gastroenterology the FirstAffiliated Hospital Suzhou University Suzhou 215006 JiangsuProvince China Department of Gastroenterology TaicangHospital the Affiliated Hospital of Suzhou University Taicang215400 Jiangsu Province China

AIM： To study the relationship between mcp-1-2518A/ G, IL-8-251A/T polymorphism and acute pancreatitis （AP） in the Han population of Suzhou, China. METHODS： A case-control study was conducted to compare the distribution of genotype and genetic frequency of mcp-1-2518A/G, IL-8-251A/T gene polymorphism among AP （n = 101）, including mild AP （n = 78） and severe AP （n = 23） and control healthy individuals （n = 120） with polymerase chain reaction- restriction fragment length polymorphism （PCR-RFLP） and dna sequencing, and analyze the relationship between the mcp-1-2518A/G, IL-8-251A/T gene polymorphism and the susceptibility to AP. RESULTS： Significant differences were found in the distribution of genotype of mcp-1-2518A/G between the healthy control group and mild AP group （χ^2 = 32.015, P 〈 0.001）, the same was evident between the healthy control group and severe AP group （χ^2 = 12.932, P 〈 0.05） in Suzhou. However, no difference of genotypic distribution was noted between MAP and SAP （Z2 = 0.006, P = 0.997）. The genetic frequencies of G allele in mild AP were 72.4% （113/156） and 76.1% （35/46） in severe AP, both were higher than the controls, 47.1% （113/240）（χ^2 = 24.804; P 〈 0.001, and 4,2 = 13：005; P 〈 0.001）, but no difference was found between severe AP and mild AP （χ^2 = 0.242, P = 0.623）. No difference was found in the distribution of genotype of IL-8-251A/T between the healthy control group and AP group neither in the frequency of A and T allele. CONCLUSION： The mcp-1-2518 AA genotype of the population in Suzhou may be a protective genotype of AP, while one with higher frequency of G allele is more likely to suffer from pancreatitis. But the genotype of AA and the frequency of G allele could not predict the risk of severe AP. No correlation is found between the IL-8-251 polymorphism and the liability of AP.

关键词： Acute pancreatitis mcp-1 dna IL-8 dna Polymorphism

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